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- W3206351245 abstract "This study aims to analyze the efficacy of checkpoint inhibitor-based immunotherapy in advanced lung cancer patients, and explore the prognosis factors. Lung cancer patients treated with checkpoint inhibitor-based immunotherapy at a single institution from May 2017 to May 2020 were reviewed retrospectively. Tumor response was assessed according to immune response evaluation criteria in solid tumors (iRECIST). Survival estimates were evaluated as overall survival (OS) and progression free survival (PFS) by Kaplan-Meier survival curves. Prognosis factors were assessed by univariate and multivariate Cox-regression analyses. Checkpoint inhibitor-based immunotherapy was administered in 84 lung cancer patients. Among these patients, only one was complete response, 25 were partial response, 34 were stable diseases and 24 were progressive disease. The median OS and median PFS were 25.93months and 6.90months, respectively. Cox multivariate analysis showed that, application of large dose corticosteroids (HR = 2.518，P = 0.004), late-line treatment（HR = 2.394，P = 0.003）and higher neutrophil to lymphocyte ratio (NLR) (HR = 2.682，P = 0.001) were related with poorer PFS. Application of large dose corticosteroids (HR = 3.216，P = 0.002) and higher NLR (HR = 4.125，P < 0.001) were associated with poorer OS. Checkpoint inhibitor-based immunotherapy is an effective strategy for advanced lung cancer patients. Patients who get first line immunotherapy may get more survival benefits, NLR level at the first best response might be a prognosis factor, and application of high dose corticosteroids was associated with poor prognosis." @default.
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- W3206351245 date "2021-10-01" @default.
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- W3206351245 title "P42.04 Prognosis Factors in Advanced Lung Cancer Patients Treated With Checkpoint Inhibitor-Based Immunotherapy" @default.
- W3206351245 doi "https://doi.org/10.1016/j.jtho.2021.08.463" @default.
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