FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206353721> ?p ?o ?g. }

• W3206353721 abstract "Background: Cardiovascular and renal effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been inconsistent in cardiovascular outcome trials, and factors associated with the efficacy of GLP-1RAs remain to be clarified. Objective: To evaluate cardiovascular and renal outcomes with GLP-1RAs and associations between these outcomes and the magnitude of HbA1c or weight reduction. Data Sources and Study selection: We searched PubMed/MEDLINE for randomized, placebo-controlled trials of GLP-1RAs published until 11 August 2021 and selected trials reporting major adverse cardiovascular events (MACE) as the primary outcome. Data Extraction and Synthesis: We extracted data of 60,080 individuals from eight studies (ELIXA, LEADER, SUSTAIN-6, EXSCEL, HARMONY, PIONEER 6, REWIND, and AMPLITUDE-O) and conducted a meta-analysis with a random-effects model to calculate pooled hazard ratios (HRs) of primary and secondary outcomes. Furthermore, we performed a univariable meta-regression analysis of these outcomes with HbA1c or weight reduction. Main outcomes and Measures: The primary outcome was MACE (a composite of cardiovascular mortality, nonfatal stroke, and nonfatal myocardial infarction). Secondary outcomes included components of MACE, all-cause mortality, hospitalization due to heart failure, and renal outcomes. Safety outcomes were severe hypoglycemia, pancreatitis, pancreatic cancer, and retinopathy. Results: GLP-1RAs reduced MACE (HR 0.86; 95% CI 0.80, 0.93; P < 0.001) and secondary outcomes including cardiovascular mortality (0.87; 0.80 0.94; P = 0.001), nonfatal myocardial infarction (0.90; 0.83, 0.98; P = 0.020) nonfatal stroke (0.83; 0.76, 0.92; P < 0.001), and the composite renal outcome (0.80; 0.73, 0.87; P < 0.001). No increase in the incidence of safety outcomes was observed with GLP-1RAs. Meta-regression analysis showed that HbA1c reduction was associated with logarithm of HR (log-HR) of MACE (P = 0.045; R2 = 0.64) and the composite renal outcome (P = 0.045; R2 = 0.80), whereas weight reduction was not associated with any outcome. Every 1.0% HbA1c reduction was associated with a decrease in log-HR of MACE and the composite renal outcome by 0.27 and 0.35, respectively. Conclusions: GLP-1RAs showed favorable effects on cardiovascular and renal outcomes. Furthermore, reduction in HbA1c, but not body weight, was associated with cardiovascular and renal risk reduction during the treatment with GLP-1RAs." @default.
• W3206353721 created "2021-10-25" @default.
• W3206353721 creator A5001058332 @default.
• W3206353721 creator A5016490953 @default.
• W3206353721 creator A5047729964 @default.
• W3206353721 creator A5049754800 @default.
• W3206353721 creator A5060317581 @default.
• W3206353721 creator A5077189198 @default.
• W3206353721 date "2021-10-16" @default.
• W3206353721 modified "2023-10-16" @default.
• W3206353721 title "Effects of Glucagon-like Peptide-1 Receptor Agonists on Cardiovascular and Renal Outcomes: A Systematic Review, Meta-analysis, and Meta-regression Analysis" @default.
• W3206353721 cites W1752045965 @default.
• W3206353721 cites W2054143933 @default.
• W3206353721 cites W2054981500 @default.
• W3206353721 cites W2098923148 @default.
• W3206353721 cites W2117200377 @default.
• W3206353721 cites W2128825255 @default.
• W3206353721 cites W2150959326 @default.
• W3206353721 cites W2152984355 @default.
• W3206353721 cites W2161701454 @default.
• W3206353721 cites W2171294019 @default.
• W3206353721 cites W2188846692 @default.
• W3206353721 cites W2282578582 @default.
• W3206353721 cites W2337454357 @default.
• W3206353721 cites W2425644022 @default.
• W3206353721 cites W2443999297 @default.
• W3206353721 cites W2475233216 @default.
• W3206353721 cites W2519510391 @default.
• W3206353721 cites W2754041380 @default.
• W3206353721 cites W2768111757 @default.
• W3206353721 cites W2769264260 @default.
• W3206353721 cites W2774952509 @default.
• W3206353721 cites W2893883775 @default.
• W3206353721 cites W2894746763 @default.
• W3206353721 cites W2894993577 @default.
• W3206353721 cites W2900848270 @default.
• W3206353721 cites W2948612418 @default.
• W3206353721 cites W2948622224 @default.
• W3206353721 cites W2964087648 @default.
• W3206353721 cites W2964603908 @default.
• W3206353721 cites W2973758715 @default.
• W3206353721 cites W3021856094 @default.
• W3206353721 cites W3047536039 @default.
• W3206353721 cites W3092017935 @default.
• W3206353721 cites W3118615836 @default.
• W3206353721 cites W3163402894 @default.
• W3206353721 cites W3177365549 @default.
• W3206353721 cites W3192887403 @default.
• W3206353721 doi "https://doi.org/10.1101/2021.10.14.21264803" @default.
• W3206353721 hasPublicationYear "2021" @default.
• W3206353721 type Work @default.
• W3206353721 sameAs 3206353721 @default.
• W3206353721 citedByCount "0" @default.
• W3206353721 crossrefType "posted-content" @default.
• W3206353721 hasAuthorship W3206353721A5001058332 @default.
• W3206353721 hasAuthorship W3206353721A5016490953 @default.
• W3206353721 hasAuthorship W3206353721A5047729964 @default.
• W3206353721 hasAuthorship W3206353721A5049754800 @default.
• W3206353721 hasAuthorship W3206353721A5060317581 @default.
• W3206353721 hasAuthorship W3206353721A5077189198 @default.
• W3206353721 hasBestOaLocation W32063537211 @default.
• W3206353721 hasConcept C126322002 @default.
• W3206353721 hasConcept C127413603 @default.
• W3206353721 hasConcept C207103383 @default.
• W3206353721 hasConcept C2780400711 @default.
• W3206353721 hasConcept C2780645631 @default.
• W3206353721 hasConcept C2780739214 @default.
• W3206353721 hasConcept C44249647 @default.
• W3206353721 hasConcept C500558357 @default.
• W3206353721 hasConcept C71924100 @default.
• W3206353721 hasConcept C78519656 @default.
• W3206353721 hasConcept C95190672 @default.
• W3206353721 hasConceptScore W3206353721C126322002 @default.
• W3206353721 hasConceptScore W3206353721C127413603 @default.
• W3206353721 hasConceptScore W3206353721C207103383 @default.
• W3206353721 hasConceptScore W3206353721C2780400711 @default.
• W3206353721 hasConceptScore W3206353721C2780645631 @default.
• W3206353721 hasConceptScore W3206353721C2780739214 @default.
• W3206353721 hasConceptScore W3206353721C44249647 @default.
• W3206353721 hasConceptScore W3206353721C500558357 @default.
• W3206353721 hasConceptScore W3206353721C71924100 @default.
• W3206353721 hasConceptScore W3206353721C78519656 @default.
• W3206353721 hasConceptScore W3206353721C95190672 @default.
• W3206353721 hasLocation W32063537211 @default.
• W3206353721 hasOpenAccess W3206353721 @default.
• W3206353721 hasPrimaryLocation W32063537211 @default.
• W3206353721 hasRelatedWork W2089715561 @default.
• W3206353721 hasRelatedWork W2100465349 @default.
• W3206353721 hasRelatedWork W2319391564 @default.
• W3206353721 hasRelatedWork W2324918298 @default.
• W3206353721 hasRelatedWork W2333974794 @default.
• W3206353721 hasRelatedWork W2937666887 @default.
• W3206353721 hasRelatedWork W3177765220 @default.
• W3206353721 hasRelatedWork W4239328741 @default.
• W3206353721 hasRelatedWork W4253895101 @default.
• W3206353721 hasRelatedWork W4255422713 @default.
• W3206353721 isParatext "false" @default.
• W3206353721 isRetracted "false" @default.
• W3206353721 magId "3206353721" @default.
• W3206353721 workType "article" @default.