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• W3206368596 abstract "Cervical carcinoma is a global public health burden. Given that it is usually asymptomatic at potentially curative stages, the development of clinically accurate tests is critical for early detection and individual risk stratification. The present study performed an integrative meta-analysis of the transcriptomes from 10 cervical carcinoma cohorts, with the aim of identifying biomarkers that are associated with malignant transformation of cervical epithelium, and establish their clinical applicability. From among the top ranked differentially expressed genes, flap structure-specific endonuclease 1 (FEN1) and poly (U)-specific endoribonuclease (ENDOU) were selected for further validation, and their clinical applicability was assessed using immunohistochemically stained microarrays comprising 110 tissue cores, using p16 and Ki67 staining as the comparator tests. The results demonstrated that FEN1 expression was significantly upregulated in 65% of tumor specimens (P=0.0001), with no detectable expression in the non-tumor tissues. Furthermore, its expression was significantly associated with Ki67 staining in tumor samples (P<0.0001), but no association was observed with p16 expression or the presence of human papilloma virus types 16/18, patient age, tumor grade or stage. FEN1 staining demonstrated lower sensitivity than p16 (69.3 vs. 96.8%) and Ki67 (69.3 vs. 76.3%); however, the specificity was identical to p16 and higher than that of Ki67 (100 vs. 71.4%).ENDOU staining was consistent with the microarray results, demonstrating 1% positivity in tumors and 40% positivity in non-tumor tissues. Gene set enrichment analysis of cervical tumors overexpressing FEN1 revealed its association with enhanced growth factor signaling, immune response inhibition and extracellular matrix remodeling, whereas tumors with low ENDOU expression exhibited inhibition of epithelial development and differentiation processes. Taken together, the results of the present study demonstrate the feasibility of the integrative meta-analysis approach to identify relevant biomarkers associated with cervical carcinogenesis. Thus, FEN1 and ENDOU may be useful diagnostic biomarkers for squamous cervical carcinoma. However, further studies are required to determine their diagnostic performance in larger patient cohorts and validate the results presented here." @default.
• W3206368596 created "2021-10-25" @default.
• W3206368596 creator A5029823467 @default.
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• W3206368596 date "2021-10-19" @default.
• W3206368596 modified "2023-10-11" @default.
• W3206368596 title "Integrative meta‑analysis of gene expression profiles identifies FEN1 and ENDOU as potential diagnostic biomarkers for cervical squamous cell carcinoma" @default.
• W3206368596 cites W1482695768 @default.
• W3206368596 cites W1566831845 @default.
• W3206368596 cites W1591837399 @default.
• W3206368596 cites W1875984885 @default.
• W3206368596 cites W1911921731 @default.
• W3206368596 cites W1966481117 @default.
• W3206368596 cites W1967012453 @default.
• W3206368596 cites W1973094248 @default.
• W3206368596 cites W1973914781 @default.
• W3206368596 cites W1981774836 @default.
• W3206368596 cites W1987115840 @default.
• W3206368596 cites W1987350137 @default.
• W3206368596 cites W1988941274 @default.
• W3206368596 cites W1998248450 @default.
• W3206368596 cites W2004344128 @default.
• W3206368596 cites W2007618242 @default.
• W3206368596 cites W2008634558 @default.
• W3206368596 cites W2013700000 @default.
• W3206368596 cites W2024010247 @default.
• W3206368596 cites W2026125672 @default.
• W3206368596 cites W2030205286 @default.
• W3206368596 cites W2039600854 @default.
• W3206368596 cites W2054877486 @default.
• W3206368596 cites W2072252047 @default.
• W3206368596 cites W2077641119 @default.
• W3206368596 cites W2078612444 @default.
• W3206368596 cites W2081098333 @default.
• W3206368596 cites W2083158919 @default.
• W3206368596 cites W2100775423 @default.
• W3206368596 cites W2106608030 @default.
• W3206368596 cites W2108108142 @default.
• W3206368596 cites W2115240529 @default.
• W3206368596 cites W2116634113 @default.
• W3206368596 cites W2118055139 @default.
• W3206368596 cites W2129356320 @default.
• W3206368596 cites W2130410032 @default.
• W3206368596 cites W2132498702 @default.
• W3206368596 cites W2133465414 @default.
• W3206368596 cites W2134053713 @default.
• W3206368596 cites W2139168999 @default.
• W3206368596 cites W2140099276 @default.
• W3206368596 cites W2148028028 @default.
• W3206368596 cites W2148708580 @default.
• W3206368596 cites W2159707944 @default.
• W3206368596 cites W2162451014 @default.
• W3206368596 cites W2169353806 @default.
• W3206368596 cites W2172112030 @default.
• W3206368596 cites W2201597344 @default.
• W3206368596 cites W2211624916 @default.
• W3206368596 cites W2229135620 @default.
• W3206368596 cites W2230320310 @default.
• W3206368596 cites W2261971875 @default.
• W3206368596 cites W2322843244 @default.
• W3206368596 cites W2338525040 @default.
• W3206368596 cites W2427293258 @default.
• W3206368596 cites W2510985818 @default.
• W3206368596 cites W2511137141 @default.
• W3206368596 cites W2575837388 @default.
• W3206368596 cites W2595495729 @default.
• W3206368596 cites W2603131111 @default.
• W3206368596 cites W2605976750 @default.
• W3206368596 cites W2755262202 @default.
• W3206368596 cites W2761795872 @default.
• W3206368596 cites W2778876312 @default.
• W3206368596 cites W2802409103 @default.
• W3206368596 cites W2900569176 @default.
• W3206368596 cites W2943528992 @default.
• W3206368596 cites W2966553109 @default.
• W3206368596 cites W2993250673 @default.
• W3206368596 cites W3006137721 @default.
• W3206368596 cites W3012173019 @default.
• W3206368596 cites W3020251873 @default.
• W3206368596 cites W3092374644 @default.
• W3206368596 cites W3128801603 @default.
• W3206368596 cites W3131550731 @default.
• W3206368596 cites W3139511935 @default.
• W3206368596 cites W3164716556 @default.
• W3206368596 cites W3177364614 @default.
• W3206368596 cites W4206682086 @default.
• W3206368596 cites W4234255852 @default.
• W3206368596 cites W4239819457 @default.
• W3206368596 cites W96723709 @default.
• W3206368596 doi "https://doi.org/10.3892/ol.2021.13101" @default.
• W3206368596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8548783" @default.
• W3206368596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34712364" @default.
• W3206368596 hasPublicationYear "2021" @default.
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