FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206395636> ?p ?o ?g. }

• W3206395636 endingPage "1453" @default.
• W3206395636 startingPage "1453" @default.
• W3206395636 abstract "One of the most challenging problems in the treatment of glioblastoma (GBM) is the highly infiltrative nature of the disease. Infiltrating cells that are non-resectable are left behind after debulking surgeries and become a source of regrowth and recurrence. To prevent tumor recurrence and increase patient survival, it is necessary to cleanse the adjacent tissue from GBM infiltrates. This requires an innovative local approach. One such approach is that of photodynamic therapy (PDT) which uses specific light-sensitizing agents called photosensitizers. Here, we show that tetramethylrhodamine methyl ester (TMRM), which has been used to asses mitochondrial potential, can be used as a photosensitizer to target GBM cells. Primary patient-derived GBM cell lines were used, including those specifically isolated from the infiltrative edge. PDT with TMRM using low-intensity green light induced mitochondrial damage, an irreversible drop in mitochondrial membrane potential and led to GBM cell death. Moreover, delayed photoactivation after TMRM loading selectively killed GBM cells but not cultured rat astrocytes. The efficacy of TMRM-PDT in certain GBM cell lines may be potentiated by adenylate cyclase activator NKH477. Together, these findings identify TMRM as a prototypical mitochondrially targeted photosensitizer with beneficial features which may be suitable for preclinical and clinical translation." @default.
• W3206395636 created "2021-10-25" @default.
• W3206395636 creator A5049305040 @default.
• W3206395636 creator A5052308829 @default.
• W3206395636 creator A5059878597 @default.
• W3206395636 creator A5070887523 @default.
• W3206395636 creator A5072269935 @default.
• W3206395636 creator A5077186196 @default.
• W3206395636 date "2021-10-13" @default.
• W3206395636 modified "2023-09-27" @default.
• W3206395636 title "Feasibility of Photodynamic Therapy for Glioblastoma with the Mitochondria-Targeted Photosensitizer Tetramethylrhodamine Methyl Ester (TMRM)" @default.
• W3206395636 cites W166977550 @default.
• W3206395636 cites W1987337574 @default.
• W3206395636 cites W2011050809 @default.
• W3206395636 cites W2028338939 @default.
• W3206395636 cites W2055627530 @default.
• W3206395636 cites W2073922382 @default.
• W3206395636 cites W2086825135 @default.
• W3206395636 cites W2089663038 @default.
• W3206395636 cites W2096287682 @default.
• W3206395636 cites W2135130593 @default.
• W3206395636 cites W2137314243 @default.
• W3206395636 cites W2153159003 @default.
• W3206395636 cites W2155528804 @default.
• W3206395636 cites W2162617409 @default.
• W3206395636 cites W2320064230 @default.
• W3206395636 cites W2559364010 @default.
• W3206395636 cites W2570057121 @default.
• W3206395636 cites W2735590725 @default.
• W3206395636 cites W2749025438 @default.
• W3206395636 cites W2777214868 @default.
• W3206395636 cites W2791413803 @default.
• W3206395636 cites W2793580326 @default.
• W3206395636 cites W2889533582 @default.
• W3206395636 cites W2894074987 @default.
• W3206395636 cites W2910072132 @default.
• W3206395636 cites W3001797168 @default.
• W3206395636 cites W3004400064 @default.
• W3206395636 doi "https://doi.org/10.3390/biomedicines9101453" @default.
• W3206395636 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8533469" @default.
• W3206395636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34680569" @default.
• W3206395636 hasPublicationYear "2021" @default.
• W3206395636 type Work @default.
• W3206395636 sameAs 3206395636 @default.
• W3206395636 citedByCount "4" @default.
• W3206395636 countsByYear W32063956362022 @default.
• W3206395636 countsByYear W32063956362023 @default.
• W3206395636 crossrefType "journal-article" @default.
• W3206395636 hasAuthorship W3206395636A5049305040 @default.
• W3206395636 hasAuthorship W3206395636A5052308829 @default.
• W3206395636 hasAuthorship W3206395636A5059878597 @default.
• W3206395636 hasAuthorship W3206395636A5070887523 @default.
• W3206395636 hasAuthorship W3206395636A5072269935 @default.
• W3206395636 hasAuthorship W3206395636A5077186196 @default.
• W3206395636 hasBestOaLocation W32063956361 @default.
• W3206395636 hasConcept C178790620 @default.
• W3206395636 hasConcept C185592680 @default.
• W3206395636 hasConcept C190283241 @default.
• W3206395636 hasConcept C2776194525 @default.
• W3206395636 hasConcept C2781323092 @default.
• W3206395636 hasConcept C2781469039 @default.
• W3206395636 hasConcept C28859421 @default.
• W3206395636 hasConcept C31573885 @default.
• W3206395636 hasConcept C502942594 @default.
• W3206395636 hasConcept C54355233 @default.
• W3206395636 hasConcept C55493867 @default.
• W3206395636 hasConcept C71924100 @default.
• W3206395636 hasConcept C75473681 @default.
• W3206395636 hasConcept C81885089 @default.
• W3206395636 hasConcept C86803240 @default.
• W3206395636 hasConcept C95444343 @default.
• W3206395636 hasConceptScore W3206395636C178790620 @default.
• W3206395636 hasConceptScore W3206395636C185592680 @default.
• W3206395636 hasConceptScore W3206395636C190283241 @default.
• W3206395636 hasConceptScore W3206395636C2776194525 @default.
• W3206395636 hasConceptScore W3206395636C2781323092 @default.
• W3206395636 hasConceptScore W3206395636C2781469039 @default.
• W3206395636 hasConceptScore W3206395636C28859421 @default.
• W3206395636 hasConceptScore W3206395636C31573885 @default.
• W3206395636 hasConceptScore W3206395636C502942594 @default.
• W3206395636 hasConceptScore W3206395636C54355233 @default.
• W3206395636 hasConceptScore W3206395636C55493867 @default.
• W3206395636 hasConceptScore W3206395636C71924100 @default.
• W3206395636 hasConceptScore W3206395636C75473681 @default.
• W3206395636 hasConceptScore W3206395636C81885089 @default.
• W3206395636 hasConceptScore W3206395636C86803240 @default.
• W3206395636 hasConceptScore W3206395636C95444343 @default.
• W3206395636 hasIssue "10" @default.
• W3206395636 hasLocation W32063956361 @default.
• W3206395636 hasLocation W32063956362 @default.
• W3206395636 hasLocation W32063956363 @default.
• W3206395636 hasLocation W32063956364 @default.
• W3206395636 hasLocation W32063956365 @default.
• W3206395636 hasLocation W32063956366 @default.
• W3206395636 hasOpenAccess W3206395636 @default.
• W3206395636 hasPrimaryLocation W32063956361 @default.
• W3206395636 hasRelatedWork W2003992813 @default.
• W3206395636 hasRelatedWork W2036009413 @default.

• next