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• W3206405562 abstract "Legionella species are facultative intracellular pathogens, which can cause a life-threatening pneumonia termed Legionnaires’ disease. Legionella pneumophila employs the Legionella quorum sensing (Lqs)-LvbR network to regulate virulence and motility, but its role for growth in media is ill-defined. Compared to the parental L. pneumophila strain JR32, a ΔlqsR mutant showed a reduced lag phase at 30°C and reached a higher cell density at 45°C, while the ΔlqsA, ΔlqsS and ΔlqsT mutants exhibited a longer lag phase and reached only a lower cell density. A ΔlvbR mutant resumed growth like the parental strain at 30°C, but exhibited a substantially reduced cell density at 45°C. Thus, LvbR is an important cell density regulator at elevated temperatures. A quantitative analysis of temperature-dependent growth characteristics of environmental and clinical strains revealed that L. pneumophila strains grew in AYE medium after distinct lag phases with similar rates at 30°C, reached different cell densities at the optimal growth temperature of 40°C, and no longer grew at 50°C. Legionella longbeachae reached a rather low cell density at 40°C and did not grow at and beyond 45°C. Genes encoding components of the Lqs-LvbR network were present in the genomes of the environmental and clinical L. pneumophila isolates, and the P lqsR , P lqsA , P lqsS and P lvbR promoters from strain JR32 were active in these strains. Taken together, our results indicate that the Lqs-LvbR network governs the temperature-dependent growth onset and cell density of the L. pneumophila reference strain JR32, and possibly also of environmental and clinical L. pneumophila isolates." @default.
• W3206405562 created "2021-10-25" @default.
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• W3206405562 date "2021-10-14" @default.
• W3206405562 modified "2023-10-16" @default.
• W3206405562 title "The Legionella Lqs-LvbR regulatory network controls temperature-dependent growth onset and bacterial cell density" @default.
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• W3206405562 doi "https://doi.org/10.1101/2021.10.12.464170" @default.
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