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• W3206422280 abstract "Diffusion-weighted imaging (DWI) measures water molecules diffusivity through tissues and can be quantitatively expressed as an apparent diffusion coefficient (ADC) value. Changes anticipated in the brain tissue following death are initial tissue ischemia followed by cell lysis and membrane breakdown. However, there is limited data about brain ADC changes in fetal post mortem setting especially in delayed phase. We collected intrauterine magnetic resonance imaging (MRI) of all monochorionic pregnancies underwent radiofrequency ablation (RFA), referred to our centre from April 2018 to November 2020 because the exact time of intrauterine death can be achieved in RFA setting. Two large regions of interests (ROI) were manually placed on bilateral hemispheres of both dead and living fetuses on ADC map while avoiding adjacent structures (as CSF space) and average of ADCs were calculated. The fetuses were classified based on the post mortem interval (PMI) between MRI and RFA into two groups: A) Early (≤3 weeks) and B) late. We included 46 fetuses (37 in group A and 9 in group B). All dead fetuses in group A showed brain restriction with mean ADC values of 744±310×10-6 mm2/s (ADC values of living fetuses in this group was 1640±202×10-6 mm2/s). Mean ADC values in group B was 951±394.1 ×10-6 mm2/s (ADC values of living fetuses in this group was 1578.6±189.2×10-6 mm2/s). The mean of PMI in group A was 5.9±1.3 days (range: 1-17 days) and in group B was 34± 9.2 days (range: 20-46 days). Only two (22.2%) fetuses in group B showed no brain restriction and PMI in these fetuses was about 6–7 weeks. These data indicate that in post mortem brain as in post stroke setting, parenchymal restriction and low ADC values can persist long time after brain death. Although the ADC values were higher in group B, we did not find significant difference between ADC values of two groups." @default.
• W3206422280 created "2021-10-25" @default.
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• W3206422280 date "2021-10-01" @default.
• W3206422280 modified "2023-09-26" @default.
• W3206422280 title "VP39.01: Assessment of the time course of postmortem fetal brain changes by DWI after radiofrequency ablation for fetal reduction in monochorionic pregnancies" @default.
• W3206422280 doi "https://doi.org/10.1002/uog.24585" @default.
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