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• W3206449462 abstract "Abstract Structures of two globular proteins were determined ab initio using microcrystal electron diffraction (MicroED) data that was collected on a direct electron detector in counting mode. Microcrystals were identified using a scanning electron microscope (SEM) and thinned with a focused ion-beam (FIB) to produce crystalline lamellae of ideal thickness. Continuous rotation data were collected using an ultra-low exposure rate on a Falcon 4 direct electron detector in electron-counting mode. For the first sample, triclinic lysozyme extending to 0.87 Å resolution, an ideal helical fragment of only three alanine residues provided initial phases. These phases were improved using density modification, allowing the entire atomic structure to be built automatically. A similar approach was successful on a second macromolecular sample, proteinase K, which is much larger and diffracted to a modest 1.5 Å resolution. These results demonstrate that macromolecules can be determined to sub-Ångström resolution by MicroED and that ab initio phasing can be successfully applied to counting data collected on a direct electron detector." @default.
• W3206449462 created "2021-10-25" @default.
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• W3206449462 date "2021-10-17" @default.
• W3206449462 modified "2023-09-27" @default.
• W3206449462 title "Ab initio phasing macromolecular structures using electron-counted MicroED data" @default.
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• W3206449462 doi "https://doi.org/10.1101/2021.10.16.464672" @default.
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