Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206451105> ?p ?o ?g. }
- W3206451105 endingPage "14536" @default.
- W3206451105 startingPage "14527" @default.
- W3206451105 abstract "Highly abundant serum proteins tend to mask the low- and ultralow-abundance proteins, making low-abundance species detection extremely challenging. While traditional highly abundant protein depletion techniques are effective, they suffer from nonspecific binding problems and laborious sample manipulation procedures, and the kinetics of release of current separation systems is inadequately long, causing dilution of the eluted low-abundance protein samples. Here, we introduce an on-chip light-controlled reusable platform for the direct and fast depletion of highly abundant proteins from serum biosamples. Our nanoarrays display fast and highly selective depletion capabilities, up to 99% depletion of highly abundant protein species, with no undesired depletion effects on the concentration of low-abundance protein biomarkers. Displaying an ultrahigh surface area, ∼3400 m2 g-1, alongside a light-triggerable ultrafast release, this platform allows for a high depletion performance, together with high-yield reusability capabilities. Furthermore, this nanostructured light-controlled separation device could easily be integrated with downstream analytical technologies in a single lab-on-a-chip platform." @default.
- W3206451105 created "2021-10-25" @default.
- W3206451105 creator A5001095602 @default.
- W3206451105 creator A5032917277 @default.
- W3206451105 creator A5060258819 @default.
- W3206451105 creator A5066668509 @default.
- W3206451105 creator A5081316368 @default.
- W3206451105 date "2021-10-20" @default.
- W3206451105 modified "2023-09-28" @default.
- W3206451105 title "Depletion of Highly Abundant Protein Species from Biosamples by the Use of a Branched Silicon Nanopillar On-Chip Platform" @default.
- W3206451105 cites W130525919 @default.
- W3206451105 cites W1518504497 @default.
- W3206451105 cites W1622645825 @default.
- W3206451105 cites W1767036196 @default.
- W3206451105 cites W1904120304 @default.
- W3206451105 cites W1926181892 @default.
- W3206451105 cites W1967102831 @default.
- W3206451105 cites W1979721656 @default.
- W3206451105 cites W1980788421 @default.
- W3206451105 cites W1982184370 @default.
- W3206451105 cites W1987569561 @default.
- W3206451105 cites W1988201426 @default.
- W3206451105 cites W1998681751 @default.
- W3206451105 cites W1999718631 @default.
- W3206451105 cites W2001056153 @default.
- W3206451105 cites W2001617564 @default.
- W3206451105 cites W2006693677 @default.
- W3206451105 cites W2012354523 @default.
- W3206451105 cites W2015885619 @default.
- W3206451105 cites W2017672583 @default.
- W3206451105 cites W2020493754 @default.
- W3206451105 cites W2023096047 @default.
- W3206451105 cites W2024720397 @default.
- W3206451105 cites W2025524111 @default.
- W3206451105 cites W2025620514 @default.
- W3206451105 cites W2034687443 @default.
- W3206451105 cites W2037158541 @default.
- W3206451105 cites W2043772063 @default.
- W3206451105 cites W2046362741 @default.
- W3206451105 cites W2048333869 @default.
- W3206451105 cites W2058029133 @default.
- W3206451105 cites W2058980804 @default.
- W3206451105 cites W2060054628 @default.
- W3206451105 cites W2061611949 @default.
- W3206451105 cites W2062370684 @default.
- W3206451105 cites W2063983815 @default.
- W3206451105 cites W2063987110 @default.
- W3206451105 cites W2066054950 @default.
- W3206451105 cites W2067230356 @default.
- W3206451105 cites W2080237681 @default.
- W3206451105 cites W2084123143 @default.
- W3206451105 cites W2088261915 @default.
- W3206451105 cites W2092408608 @default.
- W3206451105 cites W2093999863 @default.
- W3206451105 cites W2098053836 @default.
- W3206451105 cites W2106889674 @default.
- W3206451105 cites W2113838337 @default.
- W3206451105 cites W2126383455 @default.
- W3206451105 cites W2134774224 @default.
- W3206451105 cites W2144979640 @default.
- W3206451105 cites W2145624550 @default.
- W3206451105 cites W2153384625 @default.
- W3206451105 cites W2164434522 @default.
- W3206451105 cites W2171158267 @default.
- W3206451105 cites W2241658922 @default.
- W3206451105 cites W2254806297 @default.
- W3206451105 cites W2312764594 @default.
- W3206451105 cites W2315204566 @default.
- W3206451105 cites W2315918862 @default.
- W3206451105 cites W2331815614 @default.
- W3206451105 cites W2340211963 @default.
- W3206451105 cites W2473818570 @default.
- W3206451105 cites W2518205861 @default.
- W3206451105 cites W2554087192 @default.
- W3206451105 cites W2673855515 @default.
- W3206451105 cites W2790553349 @default.
- W3206451105 cites W2898428119 @default.
- W3206451105 cites W2907014315 @default.
- W3206451105 cites W2965936343 @default.
- W3206451105 cites W2998672792 @default.
- W3206451105 cites W3000088187 @default.
- W3206451105 cites W3009757488 @default.
- W3206451105 cites W3026618054 @default.
- W3206451105 cites W3080647617 @default.
- W3206451105 cites W3089547844 @default.
- W3206451105 cites W3122318373 @default.
- W3206451105 cites W3160221070 @default.
- W3206451105 cites W3175261717 @default.
- W3206451105 cites W580085695 @default.
- W3206451105 cites W68401319 @default.
- W3206451105 doi "https://doi.org/10.1021/acs.analchem.1c03506" @default.
- W3206451105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8592501" @default.
- W3206451105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34668374" @default.
- W3206451105 hasPublicationYear "2021" @default.
- W3206451105 type Work @default.
- W3206451105 sameAs 3206451105 @default.
- W3206451105 citedByCount "4" @default.
- W3206451105 countsByYear W32064511052022 @default.