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- W3206451999 abstract "Background: Hepatocellular carcinoma (HCC) is more likely to occur in patients witha history of Fontan surgery, possibly due to long-term liver congestion. Protonbeam therapy (PBT) may be effective for HCC that develops after Fontan surgery. Methods: Six lesions in 5 patients (3 females, 2 males) received PBT.The median age of the patients was 33 (range 21 - 42) years, and the median ageat the time of the Fontan procedure was 6 (5 - 13) years. Four patients hadmultiple HCC at the time of PBT. The median tumor size was 57 (22 - 80) mm and4 patients were classified as Child-Pugh B. Two patients received transcatheterarterial chemoembolization before PBT. The schedule of PBT was 66 Gy (RBE) in10 fractions for 2 lesions, 72.6 Gy (RBE) in 22 fractions for 2 lesions, and 74GyE (RBE) in 37 fractions for 2 lesions. Results: The median follow-upperiod was 31 (10 - 46) months, and the numbers of survivors, deaths fromprimary diseases, and deaths from other diseases were 3, 1, and 1,respectively. There were no local recurrences, one intrahepatic metastasis, onelung metastasis, and one intrathoracic metastasis. Conclusion: Althoughexperiences on a small number of patients cannot conclude things, we believe that PBT canbe a reasonable choice of radical treatment for HCC occurring after the Fontan procedure." @default.
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- W3206451999 date "2021-01-01" @default.
- W3206451999 modified "2023-09-30" @default.
- W3206451999 title "Proton Beam Therapy for Hepatocellular Carcinoma after the Fontan Procedure" @default.
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- W3206451999 doi "https://doi.org/10.4236/jct.2021.1210046" @default.
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