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- W3206486220 abstract "In mammals, the suprachiasmatic nucleus (SCN) is a principal circadian pacemaker that optimizes the timing of behavioral rhythms and physiological events. Normally, circadian behavioral rhythms are entrained by the environmental light-dark (LD) cycle via the SCN. However, daily rhythms of other synchronizing signals, such as food availability, also emerge. When food availability is restricted to a single recurring daytime meal in nocturnal rodents, they exhibit increased activity during the hours immediately preceding feeding time; this is called food anticipatory activity (FAA). Many reports suggest that FAA is mediated by the food-entrainable oscillator (FEO) with circadian properties, but not the SCN. However, the neural locus and timekeeping mechanisms of the FEO, including its relationship with gastrointestinal hormone signaling, remain unclear. Herein, to examine whether secretin receptor signaling is necessary for the FEO, the effect of daily food restriction was studied in secretin receptor-deficient ( Sctr -/- ) mice. Adult wild-type (WT) and Sctr -/- mice were housed in separate cages containing a running wheel, with ad libitum food access and in a LD cycle (12 h: 12 h) at least 2 weeks. After acclimation to the condition, food access times were gradually restricted and 4-h restricted feeding lasted over 10 days. Subsequently, mice had ad libitum food access for 2 days and then fasted for 2 days. As a result, robust FAAs were observed in both WT and Sctr -/- mice during restricted feeding and subsequent fasting. These results indicate that secretin receptor signaling is not essential for the timekeeping mechanism of FEO." @default.
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- W3206486220 date "2021-01-01" @default.
- W3206486220 modified "2023-09-27" @default.
- W3206486220 title "Secretin Receptor-Deficient Mice Exhibit Robust Food Anticipatory Activity" @default.
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- W3206486220 doi "https://doi.org/10.2139/ssrn.3941714" @default.
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