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- W3206502180 abstract "Lipocalin-2 (LCN2) is an inflammatory protein with diverse functions in the brain. Although many studies have investigated the mechanism of LCN2 in brain injuries, the effect of LCN2 on amyloid-toxicity-related memory deficits in a mouse model of Alzheimer's disease (AD) has been less studied. We investigated the role of LCN2 in human AD patients using a mouse model of AD. We created an AD mouse model by injecting amyloid-beta oligomer (AβO) into the hippocampus. In this model, animals exhibited impaired learning and memory. We found LCN2 upregulation in the human brain frontal lobe, as well as a positive correlation between white matter ischemic changes and serum LCN2. We also found increased astrocytic LCN2, microglia activation, iron accumulation, and blood-brain barrier disruption in AβO-treated hippocampi. These findings suggest that LCN2 is involved in a variety of amyloid toxicity mechanisms, especially neuroinflammation and oxidative stress." @default.
- W3206502180 created "2021-10-25" @default.
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- W3206502180 date "2021-10-21" @default.
- W3206502180 modified "2023-10-14" @default.
- W3206502180 title "Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease" @default.
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- W3206502180 doi "https://doi.org/10.3390/antiox10111657" @default.
- W3206502180 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8614967" @default.
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