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• W3206511260 abstract "Radiotherapy plays an important role in the treatment of lung cancer, which kills cancer cells, but also damages normal structures including white blood cells in the circulation. The purpose of this study is to 1) exam whether circulating white blood cells change after radiotherapy, 2) study whether radiation dose is associated with reduction in circulating white blood cells, and 3) explore the relationship between the changes in circulating white blood cells and overall survival and quality of life (QOL). This is part of prospective pilot study. Patients with stage IV lung cancer treated with palliative radiotherapy were eligible. The variables of our interest included gender, age, stage, pathology, radiation dose, and complete white blood counts including lymphocyte, neutrophil, monocyte, and basophil. The differences of white blood cells before and after radiotherapy were calculated. Associations between radiation dose, QOL（PROMIS-29 Profile v2.1）, and survival were analyzed. Statistical significances were tested using paired t-test. Disparities in patient survival were analyzed by multivariate Cox regression models. Multivariate correlation analysis was performed using Pearson models. Ps less than 0.05 were significant. Data are presented as mean (95% confidence interval) unless otherwise specified. A total of 80 patients enrolled, 43 patients (enrolled September 2019 to September 2020) with minimum follow-up of 6-months were included in this study. There were 30 males and 13 females, aged from 39 to 85 years. The 6-month survival rates were 77% (10/43) for patients. Paired t-test showed that total counts of lymphocyte, neutrophil, monocyte, and basophil all decreased significantly after radiation (data shown in table, All P<0.05). The radiation dose, ranged 20-60 Gy/3-30Fr, was significantly and linearly correlated with the reduction in absolute lymphocyte count , percentage lymphocyte reduction and percentage neutrophil increase during RT (r=0.53, P=0.001; r=0.41, P=0.01, r=-0.35, P=0.04, respectively). The percentage reduction in lymphocyte count from the baseline was significantly associated with the sociability (P=0.03) of QOL. The decreased lymphocyte absolute value was significantly associated with pain intensity (P=0.03) of QOL. Monocyte/lymphocytes ratio was significant for overall survival (HR=5.5, 95% confidence interval 0.91-33.40,P=0.04).Table 1Paired t-testOverall survivalQOLBefore radiotherapyAfter radiotherapyPHRPSociability（P）Pain intensity（P）LYM1.56±0.690.84±0.58<0.0011.25( 0.23, 6.80 )0.90.260.03LYM%26.84±11.8615.30±9.24<0.001--0.030.20NEUT%61.64±14.3374.18±12.83<0.0014.74( 0.86, 25.99 )0.050.610.5MON0.59±0.310.44±0.230.023.60 ( 0.72, 18 )0.10.760.21BASO0.02±0.010.01±0.010.01--0.870.34MON/LYM0.43±0.310.65±0.450.015.50( 0.91, 33.40 )0.04-- Open table in a new tab This study demonstrated that palliative radiation can significantly decrease the counts of circulating white blood cells in patients with stage IV lung cancer. It is interesting to note that the ratio of monocytes to lymphocytes reduction after radiotherapy may predicted an unfavorable survival, and lymphocyte has significant impact on QOL, including measures in sociability and pain intensity." @default.
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• W3206511260 date "2021-10-01" @default.
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• W3206511260 title "P40.03 Palliative Radiotherapy Decreased Circulating White Blood Cells in Patients With Stage IV Lung Cancer" @default.
• W3206511260 doi "https://doi.org/10.1016/j.jtho.2021.08.440" @default.
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