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• W3206557648 abstract "Long-lived proteins (LLPs) are prone to deterioration with time, and one prominent breakdown process is the scission of peptide bonds. These cleavages can either be enzymatic or spontaneous. In this study, human lens proteins were examined and many were found to have been cleaved on the C-terminal side of Glu and Gln residues. Such cleavages could be reproduced experimentally by in vitro incubation of Glu- or Gln-containing peptides at physiological pHs. Spontaneous cleavage was dependent on pH and amino acid sequence. These model peptide studies suggested that the mechanism involves a cyclic intermediate and is therefore analogous to that characterized for cleavage of peptide bonds adjacent to Asp and Asn residues. An increased amount of some Glu/Gln cleaved peptides in the insoluble fraction of human lenses suggests that cleavage may act to destabilize proteins. Spontaneous cleavage at Glu and Gln, as well as recently described cross-linking at these residues, can therefore be added to the similar processes affecting long-lived proteins that have already been documented for Asn and Asp residues." @default.
• W3206557648 created "2021-10-25" @default.
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• W3206557648 date "2021-10-22" @default.
• W3206557648 modified "2023-10-11" @default.
• W3206557648 title "Spontaneous Cleavage at Glu and Gln Residues in Long-Lived Proteins" @default.
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• W3206557648 doi "https://doi.org/10.1021/acschembio.1c00379" @default.
• W3206557648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34677941" @default.
• W3206557648 hasPublicationYear "2021" @default.
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