FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206559541> ?p ?o ?g. }

• W3206559541 abstract "Myocyte differentiation is featured by adaptation processes, including mitochondria repopulation and cytoskeleton re-organization. The difference between monolayer and spheroid cultured cells at the proteomic level is uncertain. We cultivated alveolar mucosa multipotent mesenchymal stromal cells in spheroids in a myogenic way for the proper conditioning of ECM architecture and cell morphology, which induced spontaneous myogenic differentiation of cells within spheroids. Electron microscopy analysis was used for the morphometry of mitochondria biogenesis, and proteomic was used complementary to unveil events underlying differences between two-dimensional/three-dimensional myoblasts differentiation. The prevalence of elongated mitochondria with an average area of 0.097 μm2 was attributed to monolayer cells 7 days after the passage. The population of small mitochondria with a round shape and area of 0.049 μm2 (p < 0.05) was observed in spheroid cells cultured under three-dimensional conditions. Cells in spheroids were quantitatively enriched in proteins of mitochondria biogenesis (DNM1L, IDH2, SSBP1), respiratory chain (ACO2, ATP5I, COX5A), extracellular proteins (COL12A1, COL6A1, COL6A2), and cytoskeleton (MYL6, MYL12B, MYH10). Most of the Rab-related transducers were inhibited in spheroid culture. The proteomic assay demonstrated delicate mechanisms of mitochondria autophagy and repopulation, cytoskeleton assembling, and biogenesis. Differences in the ultrastructure of mitochondria indicate active biogenesis under three-dimensional conditions." @default.
• W3206559541 created "2021-10-25" @default.
• W3206559541 creator A5003090355 @default.
• W3206559541 creator A5003500932 @default.
• W3206559541 creator A5012501903 @default.
• W3206559541 creator A5016540931 @default.
• W3206559541 creator A5029781047 @default.
• W3206559541 creator A5032895839 @default.
• W3206559541 creator A5058736768 @default.
• W3206559541 creator A5065694443 @default.
• W3206559541 creator A5070640855 @default.
• W3206559541 creator A5081896743 @default.
• W3206559541 creator A5083302275 @default.
• W3206559541 date "2021-11-01" @default.
• W3206559541 modified "2023-10-14" @default.
• W3206559541 title "Proteomic and electron microscopy study of myogenic differentiation of alveolar mucosa multipotent mesenchymal stromal cells in three‐dimensional culture" @default.
• W3206559541 cites W1010312058 @default.
• W3206559541 cites W1591160078 @default.
• W3206559541 cites W1964037948 @default.
• W3206559541 cites W1969655058 @default.
• W3206559541 cites W1993788400 @default.
• W3206559541 cites W1998501721 @default.
• W3206559541 cites W2003160212 @default.
• W3206559541 cites W2006806134 @default.
• W3206559541 cites W2014191491 @default.
• W3206559541 cites W2016535776 @default.
• W3206559541 cites W2016784766 @default.
• W3206559541 cites W2018818470 @default.
• W3206559541 cites W2026318673 @default.
• W3206559541 cites W2029849110 @default.
• W3206559541 cites W2031729422 @default.
• W3206559541 cites W2032861840 @default.
• W3206559541 cites W2047311008 @default.
• W3206559541 cites W2049193450 @default.
• W3206559541 cites W2061777219 @default.
• W3206559541 cites W2063178400 @default.
• W3206559541 cites W2071486154 @default.
• W3206559541 cites W2071918153 @default.
• W3206559541 cites W2103017472 @default.
• W3206559541 cites W2114129845 @default.
• W3206559541 cites W2123275647 @default.
• W3206559541 cites W2130651484 @default.
• W3206559541 cites W2156131965 @default.
• W3206559541 cites W2164772734 @default.
• W3206559541 cites W2224270925 @default.
• W3206559541 cites W2280853449 @default.
• W3206559541 cites W2291492841 @default.
• W3206559541 cites W2331628193 @default.
• W3206559541 cites W2345664705 @default.
• W3206559541 cites W2406908932 @default.
• W3206559541 cites W2518249674 @default.
• W3206559541 cites W2529121168 @default.
• W3206559541 cites W2575985988 @default.
• W3206559541 cites W2782920871 @default.
• W3206559541 cites W2890213530 @default.
• W3206559541 cites W2922419603 @default.
• W3206559541 cites W2969443468 @default.
• W3206559541 cites W2979860221 @default.
• W3206559541 cites W3007588371 @default.
• W3206559541 cites W3036656295 @default.
• W3206559541 cites W3040632950 @default.
• W3206559541 cites W4237335579 @default.
• W3206559541 doi "https://doi.org/10.1002/pmic.202000304" @default.
• W3206559541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34674377" @default.
• W3206559541 hasPublicationYear "2021" @default.
• W3206559541 type Work @default.
• W3206559541 sameAs 3206559541 @default.
• W3206559541 citedByCount "2" @default.
• W3206559541 countsByYear W32065595412022 @default.
• W3206559541 countsByYear W32065595412023 @default.
• W3206559541 crossrefType "journal-article" @default.
• W3206559541 hasAuthorship W3206559541A5003090355 @default.
• W3206559541 hasAuthorship W3206559541A5003500932 @default.
• W3206559541 hasAuthorship W3206559541A5012501903 @default.
• W3206559541 hasAuthorship W3206559541A5016540931 @default.
• W3206559541 hasAuthorship W3206559541A5029781047 @default.
• W3206559541 hasAuthorship W3206559541A5032895839 @default.
• W3206559541 hasAuthorship W3206559541A5058736768 @default.
• W3206559541 hasAuthorship W3206559541A5065694443 @default.
• W3206559541 hasAuthorship W3206559541A5070640855 @default.
• W3206559541 hasAuthorship W3206559541A5081896743 @default.
• W3206559541 hasAuthorship W3206559541A5083302275 @default.
• W3206559541 hasConcept C142669718 @default.
• W3206559541 hasConcept C1491633281 @default.
• W3206559541 hasConcept C16930146 @default.
• W3206559541 hasConcept C175369904 @default.
• W3206559541 hasConcept C185592680 @default.
• W3206559541 hasConcept C198826908 @default.
• W3206559541 hasConcept C28859421 @default.
• W3206559541 hasConcept C502942594 @default.
• W3206559541 hasConcept C54355233 @default.
• W3206559541 hasConcept C55493867 @default.
• W3206559541 hasConcept C81885089 @default.
• W3206559541 hasConcept C86803240 @default.
• W3206559541 hasConcept C95444343 @default.
• W3206559541 hasConceptScore W3206559541C142669718 @default.
• W3206559541 hasConceptScore W3206559541C1491633281 @default.
• W3206559541 hasConceptScore W3206559541C16930146 @default.
• W3206559541 hasConceptScore W3206559541C175369904 @default.
• W3206559541 hasConceptScore W3206559541C185592680 @default.

• next