FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206564102> ?p ?o ?g. }

• W3206564102 abstract "Abdominal aortic aneurysm (AAA) is a life-threatening disorder and, therefore, investigation into its underlying mechanisms in light of the competing endogenous RNAs (ceRNAs) hypothesis has gradually increased. However, there is still lacking systematic analysis on AAA-associated circular RNA (circRNA)-microRNA (miRNA/miR)-messenger RNA (mRNA) interaction networks based on bioinformatics methods. The present study attempted to identify novel molecular biomarkers for AAA by profiling circRNA-miRNA-mRNA networks using three public microarray datasets (GSE7084, GSE57691 and GSE144431). A total of 135 differentially expressed genes (DEGs) and 142 differentially expressed circRNAs were detected using the limma R package with the statistical threshold of P<0.05 and |log2fold change (FC)| >1.5. In addition, 12 circRNA-miRNA-mRNA axes were identified to construct upregulated and downregulated ceRNA networks using Cytoscape. Based on molecular complex detection algorithm, (hsa_circ_0057691/0092108/0006845/0082182)- miR-330-5p-calponin 1 (CNN1) and (hsa_circ_0061482/0011450/0008351/0004121)-miR-326-CD8a molecule (CD8A) were recognized as the center axes in ceRNA networks. Reverse transcription-quantitative PCR results verified the significant downregulation of CNN1 and upregulation of CD8A in human AAA tissues (P<0.05). In addition, four upregulated circRNA/mRNA axes, and five downregulated circRNA/mRNA axes were revealed to have possible biological functions in the pathogenesis of AAA using the Cytoscape software. Receiver operating characteristic analysis demonstrated the accuracy of these nine DEGs involved in these axes for AAA diagnosis with area under the curves >0.80. The present study revealed novel circRNA-miRNA-mRNA networks associated with AAA, especially for CNN1 and CD8A axes with the potential function of 'focal adhesion' and 'immune response', respectively. Overall, the present findings may provide evidence to explore the implicated ceRNAs in the molecular mechanisms and as novel biomarkers for AAA." @default.
• W3206564102 created "2021-10-25" @default.
• W3206564102 creator A5022088702 @default.
• W3206564102 creator A5057640513 @default.
• W3206564102 creator A5070642270 @default.
• W3206564102 creator A5077107791 @default.
• W3206564102 date "2021-10-21" @default.
• W3206564102 modified "2023-10-01" @default.
• W3206564102 title "Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA‑miRNA‑mRNA networks" @default.
• W3206564102 cites W1270834676 @default.
• W3206564102 cites W1732757562 @default.
• W3206564102 cites W2096086497 @default.
• W3206564102 cites W2107277218 @default.
• W3206564102 cites W2128146309 @default.
• W3206564102 cites W2134629862 @default.
• W3206564102 cites W2136850043 @default.
• W3206564102 cites W2158217645 @default.
• W3206564102 cites W2210577735 @default.
• W3206564102 cites W2295124130 @default.
• W3206564102 cites W2296240596 @default.
• W3206564102 cites W2298569630 @default.
• W3206564102 cites W2530629623 @default.
• W3206564102 cites W2554050349 @default.
• W3206564102 cites W2564580570 @default.
• W3206564102 cites W2565212312 @default.
• W3206564102 cites W2766167178 @default.
• W3206564102 cites W2886610900 @default.
• W3206564102 cites W2890320044 @default.
• W3206564102 cites W2896563961 @default.
• W3206564102 cites W2897825874 @default.
• W3206564102 cites W2914934242 @default.
• W3206564102 cites W2936912607 @default.
• W3206564102 cites W2945009186 @default.
• W3206564102 cites W2949700713 @default.
• W3206564102 cites W2966757612 @default.
• W3206564102 cites W2969320960 @default.
• W3206564102 cites W2979404817 @default.
• W3206564102 cites W2991392867 @default.
• W3206564102 cites W2997440430 @default.
• W3206564102 cites W2998764392 @default.
• W3206564102 cites W3001627895 @default.
• W3206564102 cites W3004293403 @default.
• W3206564102 cites W3007384018 @default.
• W3206564102 cites W3009069380 @default.
• W3206564102 cites W3009073629 @default.
• W3206564102 cites W3012932018 @default.
• W3206564102 cites W3012944280 @default.
• W3206564102 cites W3024591104 @default.
• W3206564102 cites W3034466896 @default.
• W3206564102 cites W3037718479 @default.
• W3206564102 cites W3038517816 @default.
• W3206564102 cites W3040462533 @default.
• W3206564102 cites W3047200528 @default.
• W3206564102 cites W3093460665 @default.
• W3206564102 cites W3095146616 @default.
• W3206564102 cites W3105436135 @default.
• W3206564102 cites W3106949240 @default.
• W3206564102 cites W3164332571 @default.
• W3206564102 cites W3175988181 @default.
• W3206564102 cites W4292528167 @default.
• W3206564102 doi "https://doi.org/10.3892/etm.2021.10903" @default.
• W3206564102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8561771" @default.
• W3206564102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34737808" @default.
• W3206564102 hasPublicationYear "2021" @default.
• W3206564102 type Work @default.
• W3206564102 sameAs 3206564102 @default.
• W3206564102 citedByCount "5" @default.
• W3206564102 countsByYear W32065641022022 @default.
• W3206564102 countsByYear W32065641022023 @default.
• W3206564102 crossrefType "journal-article" @default.
• W3206564102 hasAuthorship W3206564102A5022088702 @default.
• W3206564102 hasAuthorship W3206564102A5057640513 @default.
• W3206564102 hasAuthorship W3206564102A5070642270 @default.
• W3206564102 hasAuthorship W3206564102A5077107791 @default.
• W3206564102 hasBestOaLocation W32065641021 @default.
• W3206564102 hasConcept C104317684 @default.
• W3206564102 hasConcept C105580179 @default.
• W3206564102 hasConcept C127561419 @default.
• W3206564102 hasConcept C145059251 @default.
• W3206564102 hasConcept C150194340 @default.
• W3206564102 hasConcept C18431079 @default.
• W3206564102 hasConcept C186836561 @default.
• W3206564102 hasConcept C2775893923 @default.
• W3206564102 hasConcept C2781018059 @default.
• W3206564102 hasConcept C29537977 @default.
• W3206564102 hasConcept C54355233 @default.
• W3206564102 hasConcept C60365752 @default.
• W3206564102 hasConcept C60644358 @default.
• W3206564102 hasConcept C62203573 @default.
• W3206564102 hasConcept C67082663 @default.
• W3206564102 hasConcept C70721500 @default.
• W3206564102 hasConcept C8415881 @default.
• W3206564102 hasConcept C86803240 @default.
• W3206564102 hasConceptScore W3206564102C104317684 @default.
• W3206564102 hasConceptScore W3206564102C105580179 @default.
• W3206564102 hasConceptScore W3206564102C127561419 @default.
• W3206564102 hasConceptScore W3206564102C145059251 @default.
• W3206564102 hasConceptScore W3206564102C150194340 @default.
• W3206564102 hasConceptScore W3206564102C18431079 @default.
• W3206564102 hasConceptScore W3206564102C186836561 @default.

• next