Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206568497> ?p ?o ?g. }
- W3206568497 endingPage "112974" @default.
- W3206568497 startingPage "112974" @default.
- W3206568497 abstract "Intestinal commensal fungi are vital to human health, and their metabolites play a key role in the reciprocal relationship. In the present work, eighteen alkaloids and seven monoterpenoids were isolated from the fermentation of the human intestinal fungus Penicillium oxalicum SL2, including seven undescribed alkaloids (penicilloxalines A-G), three undescribed monoterpenoids (penicilloxalines H-J), and fifteen reported compounds. The structures of the isolated compounds were identified by HRESIMS, 1D and 2D NMR, electronic circular dichroism spectra and quantum chemical calculations. Some metabolites displayed moderate agonistic effects against the pregnane X receptor (PXR), whereas (6R)3,7-dimethyl-6,7-dihydroxy-2(Z)-octenoic acid displayed a significant agonistic effect against the farnesoid X receptor (FXR) with an EC50 value of 0.43 μM, which was verified by investigating FXR downstream target genes and proteins, such as small heterodimer partner 1 (SHP1), fibroblast growth factor (FGF), and bile salt export pump (BSEP)." @default.
- W3206568497 created "2021-10-25" @default.
- W3206568497 creator A5005820972 @default.
- W3206568497 creator A5010474230 @default.
- W3206568497 creator A5045749316 @default.
- W3206568497 creator A5049279563 @default.
- W3206568497 creator A5055838753 @default.
- W3206568497 creator A5060637033 @default.
- W3206568497 creator A5061897801 @default.
- W3206568497 creator A5075720587 @default.
- W3206568497 creator A5077679168 @default.
- W3206568497 creator A5089050646 @default.
- W3206568497 date "2022-01-01" @default.
- W3206568497 modified "2023-09-25" @default.
- W3206568497 title "Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR" @default.
- W3206568497 cites W1601248103 @default.
- W3206568497 cites W1984420823 @default.
- W3206568497 cites W1991506759 @default.
- W3206568497 cites W2028046413 @default.
- W3206568497 cites W2034510170 @default.
- W3206568497 cites W2043459067 @default.
- W3206568497 cites W2045347189 @default.
- W3206568497 cites W2060741641 @default.
- W3206568497 cites W2082180544 @default.
- W3206568497 cites W2088493823 @default.
- W3206568497 cites W2093517970 @default.
- W3206568497 cites W2152606589 @default.
- W3206568497 cites W2316562406 @default.
- W3206568497 cites W2463836225 @default.
- W3206568497 cites W2563720483 @default.
- W3206568497 cites W2735999661 @default.
- W3206568497 cites W2763917661 @default.
- W3206568497 cites W2769232178 @default.
- W3206568497 cites W2790765872 @default.
- W3206568497 cites W2809649766 @default.
- W3206568497 cites W2913202311 @default.
- W3206568497 cites W2951625496 @default.
- W3206568497 cites W2970686316 @default.
- W3206568497 cites W2970977425 @default.
- W3206568497 cites W2992390777 @default.
- W3206568497 cites W3003456234 @default.
- W3206568497 cites W3025281601 @default.
- W3206568497 cites W3027146212 @default.
- W3206568497 cites W3099791077 @default.
- W3206568497 cites W3115660251 @default.
- W3206568497 cites W3159381172 @default.
- W3206568497 doi "https://doi.org/10.1016/j.phytochem.2021.112974" @default.
- W3206568497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34653908" @default.
- W3206568497 hasPublicationYear "2022" @default.
- W3206568497 type Work @default.
- W3206568497 sameAs 3206568497 @default.
- W3206568497 citedByCount "4" @default.
- W3206568497 countsByYear W32065684972022 @default.
- W3206568497 countsByYear W32065684972023 @default.
- W3206568497 crossrefType "journal-article" @default.
- W3206568497 hasAuthorship W3206568497A5005820972 @default.
- W3206568497 hasAuthorship W3206568497A5010474230 @default.
- W3206568497 hasAuthorship W3206568497A5045749316 @default.
- W3206568497 hasAuthorship W3206568497A5049279563 @default.
- W3206568497 hasAuthorship W3206568497A5055838753 @default.
- W3206568497 hasAuthorship W3206568497A5060637033 @default.
- W3206568497 hasAuthorship W3206568497A5061897801 @default.
- W3206568497 hasAuthorship W3206568497A5075720587 @default.
- W3206568497 hasAuthorship W3206568497A5077679168 @default.
- W3206568497 hasAuthorship W3206568497A5089050646 @default.
- W3206568497 hasConcept C104317684 @default.
- W3206568497 hasConcept C118552586 @default.
- W3206568497 hasConcept C132040763 @default.
- W3206568497 hasConcept C133571119 @default.
- W3206568497 hasConcept C15744967 @default.
- W3206568497 hasConcept C185592680 @default.
- W3206568497 hasConcept C187898756 @default.
- W3206568497 hasConcept C203862802 @default.
- W3206568497 hasConcept C2779448149 @default.
- W3206568497 hasConcept C55493867 @default.
- W3206568497 hasConcept C63932345 @default.
- W3206568497 hasConcept C71240020 @default.
- W3206568497 hasConcept C86339819 @default.
- W3206568497 hasConcept C86803240 @default.
- W3206568497 hasConceptScore W3206568497C104317684 @default.
- W3206568497 hasConceptScore W3206568497C118552586 @default.
- W3206568497 hasConceptScore W3206568497C132040763 @default.
- W3206568497 hasConceptScore W3206568497C133571119 @default.
- W3206568497 hasConceptScore W3206568497C15744967 @default.
- W3206568497 hasConceptScore W3206568497C185592680 @default.
- W3206568497 hasConceptScore W3206568497C187898756 @default.
- W3206568497 hasConceptScore W3206568497C203862802 @default.
- W3206568497 hasConceptScore W3206568497C2779448149 @default.
- W3206568497 hasConceptScore W3206568497C55493867 @default.
- W3206568497 hasConceptScore W3206568497C63932345 @default.
- W3206568497 hasConceptScore W3206568497C71240020 @default.
- W3206568497 hasConceptScore W3206568497C86339819 @default.
- W3206568497 hasConceptScore W3206568497C86803240 @default.
- W3206568497 hasLocation W32065684971 @default.
- W3206568497 hasLocation W32065684972 @default.
- W3206568497 hasLocation W32065684973 @default.
- W3206568497 hasOpenAccess W3206568497 @default.
- W3206568497 hasPrimaryLocation W32065684971 @default.