FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206572028> ?p ?o ?g. }

• W3206572028 endingPage "1043" @default.
• W3206572028 startingPage "1025" @default.
• W3206572028 abstract "Pituicytoma (PITUI), granular cell tumor (GCT), and spindle cell oncocytoma (SCO) are rare tumors of the posterior pituitary. Histologically, they may be challenging to distinguish and have been proposed to represent a histological spectrum of a single entity. We performed targeted next-generation sequencing, DNA methylation profiling, and copy number analysis on 47 tumors (14 PITUI; 12 GCT; 21 SCO) to investigate molecular features and explore possibilities of clinically meaningful tumor subclassification. We detected two main epigenomic subgroups by unsupervised clustering of DNA methylation data, though the overall methylation differences were subtle. The largest group (n = 23) contained most PITUIs and a subset of SCOs and was enriched for pathogenic mutations within genes in the MAPK/PI3K pathways (12/17 [71%] of sequenced tumors: FGFR1 (3), HRAS (3), BRAF (2), NF1 (2), CBL (1), MAP2K2 (1), PTEN (1)) and two with accompanying TERT promoter mutation. The second group (n = 16) contained most GCTs and a subset of SCOs, all of which mostly lacked identifiable genetic drivers. Outcome analysis demonstrated that the presence of chromosomal imbalances was significantly associated with reduced progression-free survival especially within the combined PITUI and SCO group (p = 0.031). In summary, we observed only subtle DNA methylation differences between posterior pituitary tumors, indicating that these tumors may be best classified as subtypes of a single entity. Nevertheless, our data indicate differences in mutation patterns and clinical outcome. For a clinically meaningful subclassification, we propose a combined histo-molecular approach into three subtypes: one subtype is defined by granular cell histology, scarcity of identifiable oncogenic mutations, and favorable outcome. The other two subtypes have either SCO or PITUI histology but are segregated by chromosomal copy number profile into a favorable group (no copy number changes) and a less favorable group (copy number imbalances present). Both of the latter groups have recurrent MAPK/PI3K genetic alterations that represent potential therapeutic targets." @default.
• W3206572028 created "2021-10-25" @default.
• W3206572028 creator A5003032400 @default.
• W3206572028 creator A5007938895 @default.
• W3206572028 creator A5010622002 @default.
• W3206572028 creator A5014850279 @default.
• W3206572028 creator A5017575332 @default.
• W3206572028 creator A5024124953 @default.
• W3206572028 creator A5024396423 @default.
• W3206572028 creator A5024868081 @default.
• W3206572028 creator A5028370739 @default.
• W3206572028 creator A5032731366 @default.
• W3206572028 creator A5039647180 @default.
• W3206572028 creator A5040991417 @default.
• W3206572028 creator A5041096535 @default.
• W3206572028 creator A5041796696 @default.
• W3206572028 creator A5043158080 @default.
• W3206572028 creator A5043800397 @default.
• W3206572028 creator A5049572478 @default.
• W3206572028 creator A5051104177 @default.
• W3206572028 creator A5052983963 @default.
• W3206572028 creator A5053059462 @default.
• W3206572028 creator A5057685120 @default.
• W3206572028 creator A5064456190 @default.
• W3206572028 creator A5069689120 @default.
• W3206572028 creator A5070952764 @default.
• W3206572028 creator A5080793547 @default.
• W3206572028 creator A5081827829 @default.
• W3206572028 creator A5088179286 @default.
• W3206572028 creator A5090555830 @default.
• W3206572028 date "2021-10-18" @default.
• W3206572028 modified "2023-10-18" @default.
• W3206572028 title "Genetic and epigenetic characterization of posterior pituitary tumors" @default.
• W3206572028 cites W1497882360 @default.
• W3206572028 cites W156748014 @default.
• W3206572028 cites W1675692339 @default.
• W3206572028 cites W1844026860 @default.
• W3206572028 cites W1949037014 @default.
• W3206572028 cites W1965657694 @default.
• W3206572028 cites W1975528145 @default.
• W3206572028 cites W1989277387 @default.
• W3206572028 cites W1991324482 @default.
• W3206572028 cites W2019564564 @default.
• W3206572028 cites W2020896498 @default.
• W3206572028 cites W2022864442 @default.
• W3206572028 cites W2035618305 @default.
• W3206572028 cites W2045983911 @default.
• W3206572028 cites W2049887628 @default.
• W3206572028 cites W2071982589 @default.
• W3206572028 cites W2077156941 @default.
• W3206572028 cites W2101870168 @default.
• W3206572028 cites W2103017472 @default.
• W3206572028 cites W2108987552 @default.
• W3206572028 cites W2119657919 @default.
• W3206572028 cites W2123929789 @default.
• W3206572028 cites W2126595521 @default.
• W3206572028 cites W2129915465 @default.
• W3206572028 cites W2134051904 @default.
• W3206572028 cites W2145758869 @default.
• W3206572028 cites W2146267855 @default.
• W3206572028 cites W2146512944 @default.
• W3206572028 cites W2169438753 @default.
• W3206572028 cites W2286322195 @default.
• W3206572028 cites W2321752055 @default.
• W3206572028 cites W2351893838 @default.
• W3206572028 cites W2366536035 @default.
• W3206572028 cites W2406250479 @default.
• W3206572028 cites W2419676046 @default.
• W3206572028 cites W2555272704 @default.
• W3206572028 cites W2558083607 @default.
• W3206572028 cites W2752428744 @default.
• W3206572028 cites W2776408588 @default.
• W3206572028 cites W2787816121 @default.
• W3206572028 cites W2799789512 @default.
• W3206572028 cites W2811036728 @default.
• W3206572028 cites W2897910616 @default.
• W3206572028 cites W2899389320 @default.
• W3206572028 cites W2911561283 @default.
• W3206572028 cites W2911576431 @default.
• W3206572028 cites W2917215036 @default.
• W3206572028 cites W2921116448 @default.
• W3206572028 cites W2947463221 @default.
• W3206572028 cites W2955942214 @default.
• W3206572028 cites W2967361057 @default.
• W3206572028 cites W2977162759 @default.
• W3206572028 cites W2997634430 @default.
• W3206572028 cites W3040289352 @default.
• W3206572028 cites W3112600195 @default.
• W3206572028 cites W4231254854 @default.
• W3206572028 cites W4238360954 @default.
• W3206572028 cites W4249637151 @default.
• W3206572028 cites W4254687493 @default.
• W3206572028 cites W4294141750 @default.
• W3206572028 doi "https://doi.org/10.1007/s00401-021-02377-1" @default.
• W3206572028 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8568760" @default.
• W3206572028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34661724" @default.
• W3206572028 hasPublicationYear "2021" @default.
• W3206572028 type Work @default.

• next