FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206574857> ?p ?o ?g. }

• W3206574857 endingPage "2242" @default.
• W3206574857 startingPage "2231" @default.
• W3206574857 abstract "The aim of this study was to determine the prognostic impact of right ventricular (RV)-pulmonary arterial (PA) coupling in patients with heart failure (HF) with severe secondary mitral regurgitation (SMR) enrolled in the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation) trial.RV contractile function and PA pressures influence outcomes in patients with SMR, but the impact of RV-PA coupling in patients randomized to transcatheter edge-to-edge repair (TEER) vs guideline-directed medical therapy (GDMT) is unknown.RV-PA coupling was assessed by the ratio of RV free wall longitudinal strain derived from speckle-tracking echocardiography and noninvasively measured RV systolic pressure. Advanced RV-PA uncoupling was defined as RV free wall longitudinal strain/RV systolic pressure ≤0.5%/mm Hg. The primary endpoint was a composite of all-cause mortality or HF hospitalization at 24-month follow-up.A total of 372 patients underwent speckle-tracking echocardiography, and 70.2% had advanced RV-PA uncoupling. By multivariable analysis, advanced RV-PA uncoupling was strongly associated with an increased risk for the primary 24-month endpoint of death or HF hospitalization (HR: 1.87; 95% CI: 1.31-2.66; P = 0.0005). A similar association was present for all-cause mortality alone (HR: 2.57; 95% CI: 1.54-4.29; P = 0.0003). The impact of RV-PA uncoupling was consistent in patients randomized to TEER and GDMT alone. Compared with GDMT alone, the addition of TEER improved 2-year outcomes in patients with (48.0% vs 74.8%; HR: 0.51; 95% CI: 0.37-0.71) and those without (28.8% vs 47.8%; HR: 0.51; 95% CI: 0.27-0.97) advanced RV-PA uncoupling (Pinteraction = 0.98).In the COAPT trial, advanced RV dysfunction assessed by RV-PA uncoupling was a powerful predictor of 2-year adverse outcomes in patients with HF and SMR. (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation [The COAPT Trial]; NCT01626079)." @default.
• W3206574857 created "2021-10-25" @default.
• W3206574857 creator A5003899849 @default.
• W3206574857 creator A5019062163 @default.
• W3206574857 creator A5019621498 @default.
• W3206574857 creator A5022793523 @default.
• W3206574857 creator A5027983406 @default.
• W3206574857 creator A5031383756 @default.
• W3206574857 creator A5031813912 @default.
• W3206574857 creator A5046629853 @default.
• W3206574857 creator A5053011724 @default.
• W3206574857 creator A5055613208 @default.
• W3206574857 creator A5056991193 @default.
• W3206574857 creator A5058664452 @default.
• W3206574857 creator A5066384461 @default.
• W3206574857 creator A5073083208 @default.
• W3206574857 creator A5079003605 @default.
• W3206574857 date "2021-10-01" @default.
• W3206574857 modified "2023-10-01" @default.
• W3206574857 title "Right Ventricular–Pulmonary Arterial Coupling in Patients With HF Secondary MR" @default.
• W3206574857 cites W1944829977 @default.
• W3206574857 cites W1970771731 @default.
• W3206574857 cites W1994316495 @default.
• W3206574857 cites W2058218323 @default.
• W3206574857 cites W2071250626 @default.
• W3206574857 cites W2083143484 @default.
• W3206574857 cites W2083840463 @default.
• W3206574857 cites W2124624517 @default.
• W3206574857 cites W2576706159 @default.
• W3206574857 cites W2596797126 @default.
• W3206574857 cites W2621919225 @default.
• W3206574857 cites W2736933202 @default.
• W3206574857 cites W2753637555 @default.
• W3206574857 cites W2886738924 @default.
• W3206574857 cites W2887115907 @default.
• W3206574857 cites W2888290077 @default.
• W3206574857 cites W2889688444 @default.
• W3206574857 cites W2890408977 @default.
• W3206574857 cites W2923631751 @default.
• W3206574857 cites W2975804153 @default.
• W3206574857 cites W2999724813 @default.
• W3206574857 cites W3019718479 @default.
• W3206574857 cites W3031856042 @default.
• W3206574857 cites W3127371610 @default.
• W3206574857 cites W3127999083 @default.
• W3206574857 doi "https://doi.org/10.1016/j.jcin.2021.07.047" @default.
• W3206574857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34674862" @default.
• W3206574857 hasPublicationYear "2021" @default.
• W3206574857 type Work @default.
• W3206574857 sameAs 3206574857 @default.
• W3206574857 citedByCount "33" @default.
• W3206574857 countsByYear W32065748572021 @default.
• W3206574857 countsByYear W32065748572022 @default.
• W3206574857 countsByYear W32065748572023 @default.
• W3206574857 crossrefType "journal-article" @default.
• W3206574857 hasAuthorship W3206574857A5003899849 @default.
• W3206574857 hasAuthorship W3206574857A5019062163 @default.
• W3206574857 hasAuthorship W3206574857A5019621498 @default.
• W3206574857 hasAuthorship W3206574857A5022793523 @default.
• W3206574857 hasAuthorship W3206574857A5027983406 @default.
• W3206574857 hasAuthorship W3206574857A5031383756 @default.
• W3206574857 hasAuthorship W3206574857A5031813912 @default.
• W3206574857 hasAuthorship W3206574857A5046629853 @default.
• W3206574857 hasAuthorship W3206574857A5053011724 @default.
• W3206574857 hasAuthorship W3206574857A5055613208 @default.
• W3206574857 hasAuthorship W3206574857A5056991193 @default.
• W3206574857 hasAuthorship W3206574857A5058664452 @default.
• W3206574857 hasAuthorship W3206574857A5066384461 @default.
• W3206574857 hasAuthorship W3206574857A5073083208 @default.
• W3206574857 hasAuthorship W3206574857A5079003605 @default.
• W3206574857 hasBestOaLocation W32065748571 @default.
• W3206574857 hasConcept C113280763 @default.
• W3206574857 hasConcept C126322002 @default.
• W3206574857 hasConcept C164705383 @default.
• W3206574857 hasConcept C168563851 @default.
• W3206574857 hasConcept C203092338 @default.
• W3206574857 hasConcept C2778198053 @default.
• W3206574857 hasConcept C2778296771 @default.
• W3206574857 hasConcept C2780793704 @default.
• W3206574857 hasConcept C2780930700 @default.
• W3206574857 hasConcept C2780940725 @default.
• W3206574857 hasConcept C2993373945 @default.
• W3206574857 hasConcept C71924100 @default.
• W3206574857 hasConcept C78085059 @default.
• W3206574857 hasConceptScore W3206574857C113280763 @default.
• W3206574857 hasConceptScore W3206574857C126322002 @default.
• W3206574857 hasConceptScore W3206574857C164705383 @default.
• W3206574857 hasConceptScore W3206574857C168563851 @default.
• W3206574857 hasConceptScore W3206574857C203092338 @default.
• W3206574857 hasConceptScore W3206574857C2778198053 @default.
• W3206574857 hasConceptScore W3206574857C2778296771 @default.
• W3206574857 hasConceptScore W3206574857C2780793704 @default.
• W3206574857 hasConceptScore W3206574857C2780930700 @default.
• W3206574857 hasConceptScore W3206574857C2780940725 @default.
• W3206574857 hasConceptScore W3206574857C2993373945 @default.
• W3206574857 hasConceptScore W3206574857C71924100 @default.
• W3206574857 hasConceptScore W3206574857C78085059 @default.
• W3206574857 hasFunder F4320306493 @default.

• next