FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206578656> ?p ?o ?g. }

• W3206578656 abstract "Transcriptional variability facilitates stochastic cell diversification and can in turn underpin adaptation to stress or injury. We hypothesize that it may analogously facilitate progression of pre-malignancy to cancer. To investigate this, we initiated pre-leukemia in mouse cells with enhanced transcriptional variability due to conditional disruption of the histone lysine acetyltransferase gene Kat2a. By combining single-cell RNA-sequencing of pre-leukemia with functional analysis of transformation, we show that Kat2a loss results in global variegation of cell identity and accumulation of pre-leukemic cells. Leukemia progression is subsequently facilitated by destabilization of ribosome biogenesis and protein synthesis, which confer a transient transformation advantage. The contribution of transcriptional variability to early cancer evolution reflects a generic role in promoting cell fate transitions, which, in the case of well-adapted malignancies, contrastingly differentiates and depletes cancer stem cells. In other words, transcriptional variability confers forward momentum to cell fate systems, with differential multi-stage impact throughout cancer evolution." @default.
• W3206578656 created "2021-10-25" @default.
• W3206578656 creator A5009475425 @default.
• W3206578656 creator A5015112652 @default.
• W3206578656 creator A5017274457 @default.
• W3206578656 creator A5018179125 @default.
• W3206578656 creator A5019473029 @default.
• W3206578656 creator A5029251605 @default.
• W3206578656 creator A5043345855 @default.
• W3206578656 creator A5044678591 @default.
• W3206578656 creator A5061601226 @default.
• W3206578656 creator A5070610028 @default.
• W3206578656 creator A5073443969 @default.
• W3206578656 creator A5075707240 @default.
• W3206578656 creator A5079808535 @default.
• W3206578656 creator A5079885995 @default.
• W3206578656 creator A5081020822 @default.
• W3206578656 creator A5089219628 @default.
• W3206578656 date "2021-10-18" @default.
• W3206578656 modified "2023-09-27" @default.
• W3206578656 title "Transcriptional variability accelerates pre-leukemia by cell diversification and perturbation of protein synthesis" @default.
• W3206578656 cites W1255676896 @default.
• W3206578656 cites W1736968472 @default.
• W3206578656 cites W1976033223 @default.
• W3206578656 cites W1981072394 @default.
• W3206578656 cites W1984883254 @default.
• W3206578656 cites W2023560061 @default.
• W3206578656 cites W2056677678 @default.
• W3206578656 cites W2069918359 @default.
• W3206578656 cites W2076031927 @default.
• W3206578656 cites W2085544097 @default.
• W3206578656 cites W2123303153 @default.
• W3206578656 cites W2123719503 @default.
• W3206578656 cites W2148965443 @default.
• W3206578656 cites W2150013759 @default.
• W3206578656 cites W2164327622 @default.
• W3206578656 cites W2419140434 @default.
• W3206578656 cites W2533641274 @default.
• W3206578656 cites W2741536364 @default.
• W3206578656 cites W2750218280 @default.
• W3206578656 cites W2808316845 @default.
• W3206578656 cites W2921699219 @default.
• W3206578656 cites W3003883396 @default.
• W3206578656 cites W3043941778 @default.
• W3206578656 cites W3106961467 @default.
• W3206578656 doi "https://doi.org/10.1101/2021.10.18.464824" @default.
• W3206578656 hasPublicationYear "2021" @default.
• W3206578656 type Work @default.
• W3206578656 sameAs 3206578656 @default.
• W3206578656 citedByCount "0" @default.
• W3206578656 crossrefType "posted-content" @default.
• W3206578656 hasAuthorship W3206578656A5009475425 @default.
• W3206578656 hasAuthorship W3206578656A5015112652 @default.
• W3206578656 hasAuthorship W3206578656A5017274457 @default.
• W3206578656 hasAuthorship W3206578656A5018179125 @default.
• W3206578656 hasAuthorship W3206578656A5019473029 @default.
• W3206578656 hasAuthorship W3206578656A5029251605 @default.
• W3206578656 hasAuthorship W3206578656A5043345855 @default.
• W3206578656 hasAuthorship W3206578656A5044678591 @default.
• W3206578656 hasAuthorship W3206578656A5061601226 @default.
• W3206578656 hasAuthorship W3206578656A5070610028 @default.
• W3206578656 hasAuthorship W3206578656A5073443969 @default.
• W3206578656 hasAuthorship W3206578656A5075707240 @default.
• W3206578656 hasAuthorship W3206578656A5079808535 @default.
• W3206578656 hasAuthorship W3206578656A5079885995 @default.
• W3206578656 hasAuthorship W3206578656A5081020822 @default.
• W3206578656 hasAuthorship W3206578656A5089219628 @default.
• W3206578656 hasBestOaLocation W32065786561 @default.
• W3206578656 hasConcept C104317684 @default.
• W3206578656 hasConcept C121608353 @default.
• W3206578656 hasConcept C163952510 @default.
• W3206578656 hasConcept C2778461978 @default.
• W3206578656 hasConcept C2779419633 @default.
• W3206578656 hasConcept C41091548 @default.
• W3206578656 hasConcept C502942594 @default.
• W3206578656 hasConcept C54355233 @default.
• W3206578656 hasConcept C67705224 @default.
• W3206578656 hasConcept C86339819 @default.
• W3206578656 hasConcept C86803240 @default.
• W3206578656 hasConcept C88478588 @default.
• W3206578656 hasConcept C96232424 @default.
• W3206578656 hasConceptScore W3206578656C104317684 @default.
• W3206578656 hasConceptScore W3206578656C121608353 @default.
• W3206578656 hasConceptScore W3206578656C163952510 @default.
• W3206578656 hasConceptScore W3206578656C2778461978 @default.
• W3206578656 hasConceptScore W3206578656C2779419633 @default.
• W3206578656 hasConceptScore W3206578656C41091548 @default.
• W3206578656 hasConceptScore W3206578656C502942594 @default.
• W3206578656 hasConceptScore W3206578656C54355233 @default.
• W3206578656 hasConceptScore W3206578656C67705224 @default.
• W3206578656 hasConceptScore W3206578656C86339819 @default.
• W3206578656 hasConceptScore W3206578656C86803240 @default.
• W3206578656 hasConceptScore W3206578656C88478588 @default.
• W3206578656 hasConceptScore W3206578656C96232424 @default.
• W3206578656 hasLocation W32065786561 @default.
• W3206578656 hasLocation W32065786562 @default.
• W3206578656 hasLocation W32065786563 @default.
• W3206578656 hasLocation W32065786564 @default.
• W3206578656 hasOpenAccess W3206578656 @default.
• W3206578656 hasPrimaryLocation W32065786561 @default.

• next