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- W3206580411 endingPage "118784" @default.
- W3206580411 startingPage "118784" @default.
- W3206580411 abstract "Polysaccharides can be elite carriers for therapeutic molecules due to their versatility and low probability to trigger toxicity and immunogenic responses. Local and systemic therapies can be achieved through particle pulmonary delivery, a promising non-invasive alternative. Successful pulmonary delivery requires particles with appropriate flowability to reach alveoli and avoid premature clearance mechanisms. Polysaccharides can form micro-, nano-in-micro-, and large porous particles, aerogels, and hydrogels. Herein, the characteristics of polysaccharides used in drug formulations for pulmonary delivery are reviewed, providing insights into structure-function relationships. Charged polysaccharides can confer mucoadhesion, whereas the ability for specific sugar recognition may confer targeting capacity for alveolar macrophages. The method of particle preparation must be chosen considering the properties of the components and the delivery device to be utilized. The fate of polysaccharide-based carriers is dependent on enzyme-triggered hydrolytic and/or oxidative mechanisms, allowing their complete degradation and elimination through urine or reutilization of released monosaccharides." @default.
- W3206580411 created "2021-10-25" @default.
- W3206580411 creator A5002795150 @default.
- W3206580411 creator A5011793018 @default.
- W3206580411 creator A5041458969 @default.
- W3206580411 creator A5066047810 @default.
- W3206580411 creator A5071577134 @default.
- W3206580411 creator A5079123217 @default.
- W3206580411 date "2022-02-01" @default.
- W3206580411 modified "2023-10-18" @default.
- W3206580411 title "Polysaccharide-based formulations as potential carriers for pulmonary delivery – A review of their properties and fates" @default.
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