FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206592458> ?p ?o ?g. }

• W3206592458 endingPage "117" @default.
• W3206592458 startingPage "110" @default.
• W3206592458 abstract "Type 2 diabetes (T2D) is a multifactorial and polygenetic disease, although its exact etiology remains poorly understood. The objective of this study was to identify key biomarkers and potential molecular mechanisms in the development of T2D. Human RNA-Seq datasets across different tissues (GSE18732, GSE41762, and GSE78721) were collected from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) between T2D and controls were identified using differential analysis. A total of 90 overlapping DEGs were identified, among which YTHDF2, DDX21, and MDM2 were considered as key genes due to their central positions in the PPI network and the same regulatory pattern in T2D. Logistic regression analysis showed that low expression of the key genes increased the risk of T2D. Enrichment analysis revealed that the key genes are involved in various important biological functions and signaling pathways including Notch, Fork head box O (FOXO), and phosphoinositide 3-kinase (PI3K)-Akt. RT-qPCR and Western blot analysis showed that all three key genes were down-regulated in pancreatic islets of both prediabetic and diabetic mouse models. Finally, the insulin-sensitizer, pioglitazone was used to treat db/db mice and immunofluorescence analysis showed that the expression of all three key genes was significantly down-regulated in db/db islets, an effect that was overcome by pioglitazone treatment. Together, these results suggest that the identified key genes could be involved in the development of T2D and serve as potential biomarkers and therapeutic targets for this disease." @default.
• W3206592458 created "2021-10-25" @default.
• W3206592458 creator A5001354020 @default.
• W3206592458 creator A5002005546 @default.
• W3206592458 creator A5019660567 @default.
• W3206592458 creator A5027532619 @default.
• W3206592458 creator A5034628717 @default.
• W3206592458 creator A5051051922 @default.
• W3206592458 creator A5051858597 @default.
• W3206592458 creator A5052486663 @default.
• W3206592458 creator A5053928287 @default.
• W3206592458 creator A5056639915 @default.
• W3206592458 creator A5064711465 @default.
• W3206592458 date "2021-12-01" @default.
• W3206592458 modified "2023-09-29" @default.
• W3206592458 title "Identification of MDM2, YTHDF2 and DDX21 as potential biomarkers and targets for treatment of type 2 diabetes" @default.
• W3206592458 cites W1820314031 @default.
• W3206592458 cites W1968368398 @default.
• W3206592458 cites W2014663082 @default.
• W3206592458 cites W2064652474 @default.
• W3206592458 cites W2066836020 @default.
• W3206592458 cites W2077149049 @default.
• W3206592458 cites W2085629185 @default.
• W3206592458 cites W2096173332 @default.
• W3206592458 cites W2096728243 @default.
• W3206592458 cites W2126660234 @default.
• W3206592458 cites W2158473119 @default.
• W3206592458 cites W2516762108 @default.
• W3206592458 cites W2581413639 @default.
• W3206592458 cites W2582206282 @default.
• W3206592458 cites W2856565456 @default.
• W3206592458 cites W2886504687 @default.
• W3206592458 cites W2917521450 @default.
• W3206592458 cites W2920544033 @default.
• W3206592458 cites W2924944056 @default.
• W3206592458 cites W2990137778 @default.
• W3206592458 cites W2990309084 @default.
• W3206592458 cites W3004694253 @default.
• W3206592458 cites W3017326203 @default.
• W3206592458 cites W3035203386 @default.
• W3206592458 cites W3046358682 @default.
• W3206592458 cites W3166122713 @default.
• W3206592458 cites W4211058450 @default.
• W3206592458 doi "https://doi.org/10.1016/j.bbrc.2021.10.019" @default.
• W3206592458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34688145" @default.
• W3206592458 hasPublicationYear "2021" @default.
• W3206592458 type Work @default.
• W3206592458 sameAs 3206592458 @default.
• W3206592458 citedByCount "3" @default.
• W3206592458 countsByYear W32065924582022 @default.
• W3206592458 countsByYear W32065924582023 @default.
• W3206592458 crossrefType "journal-article" @default.
• W3206592458 hasAuthorship W3206592458A5001354020 @default.
• W3206592458 hasAuthorship W3206592458A5002005546 @default.
• W3206592458 hasAuthorship W3206592458A5019660567 @default.
• W3206592458 hasAuthorship W3206592458A5027532619 @default.
• W3206592458 hasAuthorship W3206592458A5034628717 @default.
• W3206592458 hasAuthorship W3206592458A5051051922 @default.
• W3206592458 hasAuthorship W3206592458A5051858597 @default.
• W3206592458 hasAuthorship W3206592458A5052486663 @default.
• W3206592458 hasAuthorship W3206592458A5053928287 @default.
• W3206592458 hasAuthorship W3206592458A5056639915 @default.
• W3206592458 hasAuthorship W3206592458A5064711465 @default.
• W3206592458 hasConcept C104317684 @default.
• W3206592458 hasConcept C134018914 @default.
• W3206592458 hasConcept C2777180221 @default.
• W3206592458 hasConcept C502942594 @default.
• W3206592458 hasConcept C54355233 @default.
• W3206592458 hasConcept C555293320 @default.
• W3206592458 hasConcept C60644358 @default.
• W3206592458 hasConcept C70721500 @default.
• W3206592458 hasConcept C86803240 @default.
• W3206592458 hasConceptScore W3206592458C104317684 @default.
• W3206592458 hasConceptScore W3206592458C134018914 @default.
• W3206592458 hasConceptScore W3206592458C2777180221 @default.
• W3206592458 hasConceptScore W3206592458C502942594 @default.
• W3206592458 hasConceptScore W3206592458C54355233 @default.
• W3206592458 hasConceptScore W3206592458C555293320 @default.
• W3206592458 hasConceptScore W3206592458C60644358 @default.
• W3206592458 hasConceptScore W3206592458C70721500 @default.
• W3206592458 hasConceptScore W3206592458C86803240 @default.
• W3206592458 hasLocation W32065924581 @default.
• W3206592458 hasLocation W32065924582 @default.
• W3206592458 hasOpenAccess W3206592458 @default.
• W3206592458 hasPrimaryLocation W32065924581 @default.
• W3206592458 hasRelatedWork W1603543036 @default.
• W3206592458 hasRelatedWork W2009966535 @default.
• W3206592458 hasRelatedWork W2019988726 @default.
• W3206592458 hasRelatedWork W2082530227 @default.
• W3206592458 hasRelatedWork W2088063203 @default.
• W3206592458 hasRelatedWork W2169501356 @default.
• W3206592458 hasRelatedWork W2171277769 @default.
• W3206592458 hasRelatedWork W2621242303 @default.
• W3206592458 hasRelatedWork W2837554060 @default.
• W3206592458 hasRelatedWork W2909382709 @default.
• W3206592458 hasVolume "581" @default.
• W3206592458 isParatext "false" @default.
• W3206592458 isRetracted "false" @default.

• next