FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206599239> ?p ?o ?g. }

• W3206599239 endingPage "136" @default.
• W3206599239 startingPage "117" @default.
• W3206599239 abstract "Promising results from previous studies using cell therapy have paved the way for an innovative treatment option for amyotrophic lateral sclerosis (ALS). There is considerable evidence of immune and inflammatory abnormalities in ALS. Bone marrow mononuclear cells (BMMNCs) possess immunomodulatory properties and could contribute to slowing of disease progression. Aim of our study was to evaluate the long-term effect of autologous BMMNCs combined with standard treatment on survival duration in a large population and to evaluate effect of type of onset and hormonal status on survival duration in the intervention group. This controlled, retrospective study spanned over 10 years, 5 months; included 216 patients with probable or definite ALS, 150 in intervention group receiving autologous BMMNCs and standard treatment, and 66 in control group receiving only standard treatment. The estimated survival duration of control group and intervention group was computed and compared using Kaplan Meier analysis. Survival duration of patients with different types of onset and hormonal status was compared within the intervention group. None of the patients reported any major adverse events related to cell administration or the procedure. Kaplan Meier analysis estimated survival duration in the intervention group to be 91.7 months while 49.7 months in the control group ( p = 0.008). Within the intervention group, estimated survival was significantly higher ( p = 0.013) in patients with limb onset (102.3 months) vs. bulbar onset (49.9 months); premenopausal women (93.1 months) vs. postmenopausal women (57.6 months) ( p = 0.002); and preandropausal men (153.7 months) vs. postandropausal males (56.5 months) ( p = 0.006). Cell therapy using autologous BMMNCs along with standard treatment offers a promising and safe option for ALS with the potential of long term beneficial effect and increased survival. Limb onset patients, premenopausal women and men ≤ 40 years of age demonstrated better treatment efficacy." @default.
• W3206599239 created "2021-10-25" @default.
• W3206599239 creator A5006338892 @default.
• W3206599239 creator A5010977971 @default.
• W3206599239 creator A5017815666 @default.
• W3206599239 creator A5020503787 @default.
• W3206599239 creator A5023503888 @default.
• W3206599239 creator A5063125292 @default.
• W3206599239 creator A5070638392 @default.
• W3206599239 creator A5081171802 @default.
• W3206599239 creator A5086552719 @default.
• W3206599239 date "2021-06-01" @default.
• W3206599239 modified "2023-10-17" @default.
• W3206599239 title "Improved survival in amyotrophic lateral sclerosis patients following autologous bone marrow mononuclear cell therapy: a long term 10-year retrospective study" @default.
• W3206599239 cites W1566491090 @default.
• W3206599239 cites W1598042935 @default.
• W3206599239 cites W1599038895 @default.
• W3206599239 cites W1622777525 @default.
• W3206599239 cites W18768637 @default.
• W3206599239 cites W1894493322 @default.
• W3206599239 cites W1964030946 @default.
• W3206599239 cites W1968109664 @default.
• W3206599239 cites W1968427639 @default.
• W3206599239 cites W1969942100 @default.
• W3206599239 cites W1970572671 @default.
• W3206599239 cites W1971218073 @default.
• W3206599239 cites W1972656994 @default.
• W3206599239 cites W1975872544 @default.
• W3206599239 cites W1976725490 @default.
• W3206599239 cites W1978370369 @default.
• W3206599239 cites W1980639550 @default.
• W3206599239 cites W1980867773 @default.
• W3206599239 cites W1981409516 @default.
• W3206599239 cites W1987522740 @default.
• W3206599239 cites W1994177774 @default.
• W3206599239 cites W1996973828 @default.
• W3206599239 cites W1998975866 @default.
• W3206599239 cites W2013078581 @default.
• W3206599239 cites W2018110972 @default.
• W3206599239 cites W2020059513 @default.
• W3206599239 cites W2020844167 @default.
• W3206599239 cites W2023509574 @default.
• W3206599239 cites W2028635283 @default.
• W3206599239 cites W2032847865 @default.
• W3206599239 cites W2034254855 @default.
• W3206599239 cites W2034842853 @default.
• W3206599239 cites W2036119801 @default.
• W3206599239 cites W2038387222 @default.
• W3206599239 cites W2045655578 @default.
• W3206599239 cites W2045798092 @default.
• W3206599239 cites W2049407128 @default.
• W3206599239 cites W2057100984 @default.
• W3206599239 cites W2058140531 @default.
• W3206599239 cites W2061567079 @default.
• W3206599239 cites W2063799957 @default.
• W3206599239 cites W2063838755 @default.
• W3206599239 cites W2064640860 @default.
• W3206599239 cites W2064752834 @default.
• W3206599239 cites W2064982871 @default.
• W3206599239 cites W2066259320 @default.
• W3206599239 cites W2066996015 @default.
• W3206599239 cites W2067014198 @default.
• W3206599239 cites W2067977709 @default.
• W3206599239 cites W2069399162 @default.
• W3206599239 cites W2072204165 @default.
• W3206599239 cites W2073264699 @default.
• W3206599239 cites W2073864172 @default.
• W3206599239 cites W2083959138 @default.
• W3206599239 cites W2095832155 @default.
• W3206599239 cites W2096386031 @default.
• W3206599239 cites W2097367691 @default.
• W3206599239 cites W2101069762 @default.
• W3206599239 cites W2102238895 @default.
• W3206599239 cites W2106105150 @default.
• W3206599239 cites W2114803648 @default.
• W3206599239 cites W2115803656 @default.
• W3206599239 cites W2119665388 @default.
• W3206599239 cites W2120950413 @default.
• W3206599239 cites W2121500739 @default.
• W3206599239 cites W2122206229 @default.
• W3206599239 cites W2122491860 @default.
• W3206599239 cites W2123387289 @default.
• W3206599239 cites W2126824828 @default.
• W3206599239 cites W2128084057 @default.
• W3206599239 cites W2128167427 @default.
• W3206599239 cites W2128766634 @default.
• W3206599239 cites W2138130369 @default.
• W3206599239 cites W2139501951 @default.
• W3206599239 cites W2141677575 @default.
• W3206599239 cites W2144536780 @default.
• W3206599239 cites W2147461659 @default.
• W3206599239 cites W2150994376 @default.
• W3206599239 cites W2155221045 @default.
• W3206599239 cites W2155921007 @default.
• W3206599239 cites W2157078177 @default.
• W3206599239 cites W2159689992 @default.
• W3206599239 cites W2161057551 @default.
• W3206599239 cites W2167105734 @default.

• next