FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206632233> ?p ?o ?g. }

• W3206632233 abstract "The BRCA2 tumor suppressor protects genome integrity by promoting homologous recombination-based repair of DNA breaks, stability of stalled DNA replication forks and DNA damage-induced cell cycle checkpoints. BRCA2 deficient cells display the radio-resistant DNA synthesis (RDS) phenotype, however the mechanism has remained elusive. Here we show that cells without BRCA2 are unable to sufficiently restrain DNA replication fork progression after DNA damage, and the underrestrained fork progression is due primarily to Primase-Polymerase (PRIMPOL)-mediated repriming of DNA synthesis downstream of lesions, leaving behind single-stranded DNA gaps. Moreover, we find that BRCA2 associates with the essential DNA replication factor MCM10 and this association suppresses PRIMPOL-mediated repriming and ssDNA gap formation, while having no impact on the stability of stalled replication forks. Our findings establish an important function for BRCA2, provide insights into replication fork control during the DNA damage response, and may have implications in tumor suppression and therapy response." @default.
• W3206632233 created "2021-10-25" @default.
• W3206632233 creator A5013002991 @default.
• W3206632233 creator A5015342151 @default.
• W3206632233 creator A5019202221 @default.
• W3206632233 creator A5020075019 @default.
• W3206632233 creator A5023985718 @default.
• W3206632233 creator A5026961383 @default.
• W3206632233 creator A5037664092 @default.
• W3206632233 creator A5038009686 @default.
• W3206632233 creator A5045977241 @default.
• W3206632233 creator A5050487618 @default.
• W3206632233 creator A5051755593 @default.
• W3206632233 creator A5059709386 @default.
• W3206632233 creator A5062849895 @default.
• W3206632233 creator A5084208774 @default.
• W3206632233 creator A5085136469 @default.
• W3206632233 creator A5091023110 @default.
• W3206632233 date "2021-10-13" @default.
• W3206632233 modified "2023-10-14" @default.
• W3206632233 title "BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage" @default.
• W3206632233 cites W1542544035 @default.
• W3206632233 cites W1929113708 @default.
• W3206632233 cites W1969513645 @default.
• W3206632233 cites W1970578083 @default.
• W3206632233 cites W1971240706 @default.
• W3206632233 cites W1992121629 @default.
• W3206632233 cites W2025234908 @default.
• W3206632233 cites W2027966589 @default.
• W3206632233 cites W2034702779 @default.
• W3206632233 cites W2038185005 @default.
• W3206632233 cites W2039575792 @default.
• W3206632233 cites W2052346097 @default.
• W3206632233 cites W2066983187 @default.
• W3206632233 cites W2090081292 @default.
• W3206632233 cites W2098335512 @default.
• W3206632233 cites W2101161126 @default.
• W3206632233 cites W2124764875 @default.
• W3206632233 cites W2124985397 @default.
• W3206632233 cites W2133657913 @default.
• W3206632233 cites W2134536765 @default.
• W3206632233 cites W2136958078 @default.
• W3206632233 cites W2139204366 @default.
• W3206632233 cites W2147126714 @default.
• W3206632233 cites W2150000259 @default.
• W3206632233 cites W2154870331 @default.
• W3206632233 cites W2155415678 @default.
• W3206632233 cites W2172571950 @default.
• W3206632233 cites W2292064491 @default.
• W3206632233 cites W2340964324 @default.
• W3206632233 cites W2571288803 @default.
• W3206632233 cites W2588123003 @default.
• W3206632233 cites W2594597600 @default.
• W3206632233 cites W2603261241 @default.
• W3206632233 cites W2607136395 @default.
• W3206632233 cites W2610738034 @default.
• W3206632233 cites W2618555131 @default.
• W3206632233 cites W2619370444 @default.
• W3206632233 cites W2627871710 @default.
• W3206632233 cites W2735446066 @default.
• W3206632233 cites W2737658553 @default.
• W3206632233 cites W2751450140 @default.
• W3206632233 cites W2763248055 @default.
• W3206632233 cites W2765875601 @default.
• W3206632233 cites W2771808827 @default.
• W3206632233 cites W2787975097 @default.
• W3206632233 cites W2906985795 @default.
• W3206632233 cites W2909385385 @default.
• W3206632233 cites W2982655986 @default.
• W3206632233 doi "https://doi.org/10.1038/s41467-021-26227-6" @default.
• W3206632233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8514439" @default.
• W3206632233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34645815" @default.
• W3206632233 hasPublicationYear "2021" @default.
• W3206632233 type Work @default.
• W3206632233 sameAs 3206632233 @default.
• W3206632233 citedByCount "28" @default.
• W3206632233 countsByYear W32066322332021 @default.
• W3206632233 countsByYear W32066322332022 @default.
• W3206632233 countsByYear W32066322332023 @default.
• W3206632233 crossrefType "journal-article" @default.
• W3206632233 hasAuthorship W3206632233A5013002991 @default.
• W3206632233 hasAuthorship W3206632233A5015342151 @default.
• W3206632233 hasAuthorship W3206632233A5019202221 @default.
• W3206632233 hasAuthorship W3206632233A5020075019 @default.
• W3206632233 hasAuthorship W3206632233A5023985718 @default.
• W3206632233 hasAuthorship W3206632233A5026961383 @default.
• W3206632233 hasAuthorship W3206632233A5037664092 @default.
• W3206632233 hasAuthorship W3206632233A5038009686 @default.
• W3206632233 hasAuthorship W3206632233A5045977241 @default.
• W3206632233 hasAuthorship W3206632233A5050487618 @default.
• W3206632233 hasAuthorship W3206632233A5051755593 @default.
• W3206632233 hasAuthorship W3206632233A5059709386 @default.
• W3206632233 hasAuthorship W3206632233A5062849895 @default.
• W3206632233 hasAuthorship W3206632233A5084208774 @default.
• W3206632233 hasAuthorship W3206632233A5085136469 @default.
• W3206632233 hasAuthorship W3206632233A5091023110 @default.
• W3206632233 hasBestOaLocation W32066322331 @default.
• W3206632233 hasConcept C102744134 @default.
• W3206632233 hasConcept C104317684 @default.
• W3206632233 hasConcept C113271649 @default.

• next