FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206656142> ?p ?o ?g. }

• W3206656142 abstract "Background: Hemorrhagic transformation (HT) is a common complication of intravenous thrombolysis with alteplase. Cardiac troponin has been found to be associated with poor prognosis and cognitive impairment in acute ischemic stroke. But studies on the relationship between troponin and HT after thrombolysis are scarce. Methods: This study retrospectively analyzed thrombolytic patients from June 2015 to June 2021 in the Second Affiliated Hospital of Wenzhou Medical University. Cardiac troponin I were measured on admission and on following days to determine the presence of elevation and dynamic changes. HT within 24-36 h after treatment was identified by cranial computed tomography (CT). Besides, a score on the modified Rankin Scale (mRS) > 2 at discharge was defined as unfavorable outcome. Univariate analysis was used to explore the factors related to the troponin elevation on admission and troponin dynamic changes. Multivariate logistic regression model was used to investigated the association between troponin elevation on admission, troponin dynamic changes and HT after thrombolysis, respectively. Results: Troponin levels on admission were measured in 377 patients, and follow-up assay was performed in 292 patients (77.5%). 39 patients (10.3%) had troponin elevation on admission, and 66 patients (22.6%) had troponin dynamic changes comprising rising and falling pattern. The pre-existing heart disease, renal insufficiency and higher stroke severity are related to both troponin elevation on admission and the subsequent troponin dynamic changes. After adjusting the potential confounding factors, logistic regression model showed that patients with troponin elevation on admission had insignificant trend to develop HT (OR 2.23, 95%CI 0.96-5.21, p = 0.063), while patients with troponin dynamic changes had significantly higher risk of HT (OR 2.27, 95%CI 1.06-4.85, p = 0.034). Compared to the troponin elevation, a statistically stronger association was present between rising troponin dynamic changes and unfavorable outcome (OR 2.20, 95%CI 1.05-4.60, p = 0.037). Conclusion: Troponin dynamic changes are associated with HT after thrombolysis. Serial measurements are quite necessary in thrombolytic patients with risk factors associated with troponin dynamic changes (e.g., advanced age, pre-existing heart disease, higher NIHSS score, and troponin elevation on admission)." @default.
• W3206656142 created "2021-10-25" @default.
• W3206656142 creator A5005022636 @default.
• W3206656142 creator A5008346473 @default.
• W3206656142 creator A5018955885 @default.
• W3206656142 creator A5031603978 @default.
• W3206656142 creator A5063904078 @default.
• W3206656142 creator A5067071125 @default.
• W3206656142 date "2021-10-13" @default.
• W3206656142 modified "2023-10-13" @default.
• W3206656142 title "Troponin Elevation on Admission Along With Dynamic Changes and Their Association With Hemorrhagic Transformation After Thrombolysis" @default.
• W3206656142 cites W155477934 @default.
• W3206656142 cites W1978614665 @default.
• W3206656142 cites W1981831023 @default.
• W3206656142 cites W1984738849 @default.
• W3206656142 cites W1988078801 @default.
• W3206656142 cites W2042989413 @default.
• W3206656142 cites W2107539197 @default.
• W3206656142 cites W2138595885 @default.
• W3206656142 cites W2140958279 @default.
• W3206656142 cites W2154280994 @default.
• W3206656142 cites W2165568749 @default.
• W3206656142 cites W2170921938 @default.
• W3206656142 cites W2258113465 @default.
• W3206656142 cites W2292172531 @default.
• W3206656142 cites W2499147672 @default.
• W3206656142 cites W2604816476 @default.
• W3206656142 cites W2738507945 @default.
• W3206656142 cites W2752738326 @default.
• W3206656142 cites W2765701379 @default.
• W3206656142 cites W2792264089 @default.
• W3206656142 cites W2792886466 @default.
• W3206656142 cites W2795390956 @default.
• W3206656142 cites W2897628450 @default.
• W3206656142 cites W2898605065 @default.
• W3206656142 cites W2982303713 @default.
• W3206656142 cites W3015422980 @default.
• W3206656142 cites W3114270534 @default.
• W3206656142 cites W3125668751 @default.
• W3206656142 cites W4238277289 @default.
• W3206656142 cites W4292339830 @default.
• W3206656142 doi "https://doi.org/10.3389/fnagi.2021.758678" @default.
• W3206656142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8548361" @default.
• W3206656142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34721002" @default.
• W3206656142 hasPublicationYear "2021" @default.
• W3206656142 type Work @default.
• W3206656142 sameAs 3206656142 @default.
• W3206656142 citedByCount "3" @default.
• W3206656142 countsByYear W32066561422022 @default.
• W3206656142 countsByYear W32066561422023 @default.
• W3206656142 crossrefType "journal-article" @default.
• W3206656142 hasAuthorship W3206656142A5005022636 @default.
• W3206656142 hasAuthorship W3206656142A5008346473 @default.
• W3206656142 hasAuthorship W3206656142A5018955885 @default.
• W3206656142 hasAuthorship W3206656142A5031603978 @default.
• W3206656142 hasAuthorship W3206656142A5063904078 @default.
• W3206656142 hasAuthorship W3206656142A5067071125 @default.
• W3206656142 hasBestOaLocation W32066561421 @default.
• W3206656142 hasConcept C115725540 @default.
• W3206656142 hasConcept C126322002 @default.
• W3206656142 hasConcept C151956035 @default.
• W3206656142 hasConcept C164705383 @default.
• W3206656142 hasConcept C2779581417 @default.
• W3206656142 hasConcept C2780931571 @default.
• W3206656142 hasConcept C3020199598 @default.
• W3206656142 hasConcept C36036425 @default.
• W3206656142 hasConcept C500558357 @default.
• W3206656142 hasConcept C541997718 @default.
• W3206656142 hasConcept C71924100 @default.
• W3206656142 hasConcept C77350462 @default.
• W3206656142 hasConceptScore W3206656142C115725540 @default.
• W3206656142 hasConceptScore W3206656142C126322002 @default.
• W3206656142 hasConceptScore W3206656142C151956035 @default.
• W3206656142 hasConceptScore W3206656142C164705383 @default.
• W3206656142 hasConceptScore W3206656142C2779581417 @default.
• W3206656142 hasConceptScore W3206656142C2780931571 @default.
• W3206656142 hasConceptScore W3206656142C3020199598 @default.
• W3206656142 hasConceptScore W3206656142C36036425 @default.
• W3206656142 hasConceptScore W3206656142C500558357 @default.
• W3206656142 hasConceptScore W3206656142C541997718 @default.
• W3206656142 hasConceptScore W3206656142C71924100 @default.
• W3206656142 hasConceptScore W3206656142C77350462 @default.
• W3206656142 hasFunder F4320336807 @default.
• W3206656142 hasLocation W32066561421 @default.
• W3206656142 hasLocation W32066561422 @default.
• W3206656142 hasLocation W32066561423 @default.
• W3206656142 hasLocation W32066561424 @default.
• W3206656142 hasOpenAccess W3206656142 @default.
• W3206656142 hasPrimaryLocation W32066561421 @default.
• W3206656142 hasRelatedWork W1491448623 @default.
• W3206656142 hasRelatedWork W2013298584 @default.
• W3206656142 hasRelatedWork W2104953152 @default.
• W3206656142 hasRelatedWork W2113610522 @default.
• W3206656142 hasRelatedWork W2407959764 @default.
• W3206656142 hasRelatedWork W2620878392 @default.
• W3206656142 hasRelatedWork W2972435168 @default.
• W3206656142 hasRelatedWork W3029571091 @default.
• W3206656142 hasRelatedWork W3126263321 @default.
• W3206656142 hasRelatedWork W4367303626 @default.
• W3206656142 hasVolume "13" @default.

• next