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- W3206673497 endingPage "e517" @default.
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- W3206673497 abstract "Glaucoma is an optic neuropathy in which the primary risk factor is increased intraocular pressure (IOP), attributed to increased resistance to trabecular outflow of aqueous humor (AH). This resistance is believed to result from trabecular degeneration secondary to chronic oxidative stress and cellular senescence but may also involve inflammatory mechanisms whose roles are little known. In fact, inflammatory processes play a major role in the pathophysiology of glaucoma to varying degrees, affecting all structures of the eye, including the ocular surface, the anterior and posterior segments, and even the visual pathways of the brain. These processes are thought to result from dysfunction of a regulatory, protective para-inflammation, becoming chronic and harmful in glaucoma. While the mechanisms of the retinal inflammation which accelerates the degeneration of retinal ganglion cells (RGCs) as well as the inflammation of the ocular surface aggravated by long-term use of preserved glaucoma eye drops have been described for several years, very little is known about the pathophysiology of trabecular inflammation in glaucoma. The objective of this literature review is to provide a synthesis of knowledge on the roles and mechanisms of inflammation in both the healthy and glaucomatous trabecular meshwork, as well as its role in the pathophysiology of glaucoma. Therefore, after a review of the mechanisms of cellular senescence and oxidative stress – sources of trabecular inflammation, we will approach the study of the expression and roles of the main inflammatory mediators within the trabecular meshwork. Finally, we will discuss current knowledge on the toxicity of glaucoma eye drops and their preservatives on the ocular surface and trabecular meshwork as well as their role in trabecular inflammation." @default.
- W3206673497 created "2021-10-25" @default.
- W3206673497 creator A5008464944 @default.
- W3206673497 creator A5032096033 @default.
- W3206673497 creator A5063479586 @default.
- W3206673497 date "2021-11-01" @default.
- W3206673497 modified "2023-10-17" @default.
- W3206673497 title "The trabecular meshwork in glaucoma: An inflammatory trabeculopathy?" @default.
- W3206673497 cites W1509507060 @default.
- W3206673497 cites W1563498244 @default.
- W3206673497 cites W1775461686 @default.
- W3206673497 cites W1902672695 @default.
- W3206673497 cites W1936592935 @default.
- W3206673497 cites W1963724774 @default.
- W3206673497 cites W1966674329 @default.
- W3206673497 cites W1966829052 @default.
- W3206673497 cites W1968192796 @default.
- W3206673497 cites W1970731633 @default.
- W3206673497 cites W1971636582 @default.
- W3206673497 cites W1972365060 @default.
- W3206673497 cites W1973654655 @default.
- W3206673497 cites W1974991464 @default.
- W3206673497 cites W1976811653 @default.
- W3206673497 cites W1979283960 @default.
- W3206673497 cites W1982396479 @default.
- W3206673497 cites W1982617109 @default.
- W3206673497 cites W1986010820 @default.
- W3206673497 cites W2001055290 @default.
- W3206673497 cites W2005499337 @default.
- W3206673497 cites W2009999952 @default.
- W3206673497 cites W2010842159 @default.
- W3206673497 cites W2015875096 @default.
- W3206673497 cites W2016323750 @default.
- W3206673497 cites W2018885276 @default.
- W3206673497 cites W2022088222 @default.
- W3206673497 cites W2024681203 @default.
- W3206673497 cites W2025486169 @default.
- W3206673497 cites W2026885531 @default.
- W3206673497 cites W2028243025 @default.
- W3206673497 cites W2031084334 @default.
- W3206673497 cites W2031792215 @default.
- W3206673497 cites W2033650789 @default.
- W3206673497 cites W2034060753 @default.
- W3206673497 cites W2043029084 @default.
- W3206673497 cites W2044000343 @default.
- W3206673497 cites W2045064645 @default.
- W3206673497 cites W2046751492 @default.
- W3206673497 cites W2052474826 @default.
- W3206673497 cites W2053889157 @default.
- W3206673497 cites W2055394384 @default.
- W3206673497 cites W2056016198 @default.
- W3206673497 cites W2058522802 @default.
- W3206673497 cites W2058840869 @default.
- W3206673497 cites W2058913320 @default.
- W3206673497 cites W2059089228 @default.
- W3206673497 cites W2059166072 @default.
- W3206673497 cites W2059407857 @default.
- W3206673497 cites W2061631515 @default.
- W3206673497 cites W2062004643 @default.
- W3206673497 cites W2062077543 @default.
- W3206673497 cites W2062899453 @default.
- W3206673497 cites W2063924232 @default.
- W3206673497 cites W2065572357 @default.
- W3206673497 cites W2067812727 @default.
- W3206673497 cites W2069681479 @default.
- W3206673497 cites W2072365851 @default.
- W3206673497 cites W2074834737 @default.
- W3206673497 cites W2078054735 @default.
- W3206673497 cites W2079959987 @default.
- W3206673497 cites W2082888717 @default.
- W3206673497 cites W2082901544 @default.
- W3206673497 cites W2086398187 @default.
- W3206673497 cites W2086438959 @default.
- W3206673497 cites W2089432090 @default.
- W3206673497 cites W2096107242 @default.
- W3206673497 cites W2099842384 @default.
- W3206673497 cites W2108069709 @default.
- W3206673497 cites W2117830637 @default.
- W3206673497 cites W2119316269 @default.
- W3206673497 cites W2120138008 @default.
- W3206673497 cites W2122295252 @default.
- W3206673497 cites W2122563776 @default.
- W3206673497 cites W2122808924 @default.
- W3206673497 cites W2125762952 @default.
- W3206673497 cites W2127049965 @default.
- W3206673497 cites W2127260441 @default.
- W3206673497 cites W2138619486 @default.
- W3206673497 cites W2140309418 @default.
- W3206673497 cites W2149848544 @default.
- W3206673497 cites W2159406914 @default.
- W3206673497 cites W2162053493 @default.
- W3206673497 cites W2162181628 @default.
- W3206673497 cites W2162316179 @default.
- W3206673497 cites W2165275387 @default.
- W3206673497 cites W2169883707 @default.
- W3206673497 cites W2307057396 @default.
- W3206673497 cites W2320593249 @default.
- W3206673497 cites W2411514470 @default.