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- W3206676628 endingPage "100669" @default.
- W3206676628 startingPage "100669" @default.
- W3206676628 abstract "The immune system plays a key role in the host defense against viral pathogens. A signaling cascade is activated upon infection involving a variety of molecules such as pattern-recognition receptors (PRRs), interleukins or antiviral interferons. Long-term immunosuppression after solid organ transplantation (SOT) mainly abrogates adaptive T-cell-mediated responses, thus highlighting the relative contribution of innate immunity. Single-nucleotide polymorphisms (SNPs) within genes coding for PRRs or soluble mediators have been associated with differential susceptibility to viral infections among SOT recipients. A protective effect against cytomegalovirus (CMV) infection or disease has been attributed to certain SNPs in TLR9 or IFNL3 genes, whereas the opposite effect has been attributed to genetic polymorphisms in TLR2, MBL2, DC-SIGN, IL10 or IFNG. The presence of SNPs in other molecules not directly involved in innate or adaptive immune responses such as aquaporins or pregnane X appear to modulate the risk of CMV or BK polyomavirus infection, respectively. Little information is available on the genetic determinants of the post-transplant susceptibility to herpesviruses causing clinical infection (herpes simplex virus or varicella zoster virus) or the replication kinetics of components of the human blood virome used as immune surrogates (Torque teno virus). The present review critically summarizes the current knowledge on how SNP genotyping would be useful to stratify SOT recipients according to the individual risk of viral infection and proposes next research steps. Genetic susceptibility testing may improve personalized medicine and contribute to minimize the risk of viral infection after SOT." @default.
- W3206676628 created "2021-10-25" @default.
- W3206676628 creator A5016258231 @default.
- W3206676628 creator A5045536586 @default.
- W3206676628 creator A5057536435 @default.
- W3206676628 creator A5062363608 @default.
- W3206676628 date "2022-01-01" @default.
- W3206676628 modified "2023-10-02" @default.
- W3206676628 title "Human genetic polymorphisms and risk of viral infection after solid organ transplantation." @default.
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- W3206676628 doi "https://doi.org/10.1016/j.trre.2021.100669" @default.
- W3206676628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34688126" @default.
- W3206676628 hasPublicationYear "2022" @default.
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