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- W3206683634 abstract "The roles of APOEε4 and APOEε2—the strongest genetic risk and protective factors for Alzheimer’s disease—in glial responses remain elusive. We tested the hypothesis that APOE alleles differentially impact glial responses by investigating their effects on the glial transcriptome from elderly control brains with no neuritic amyloid plaques. We identified a cluster of microglial genes that are upregulated in APOEε4 and downregulated in APOEε2 carriers relative to APOEε3 homozygotes. This microglia-APOE cluster is enriched in phagocytosis—including TREM2 and TYROBP—and proinflammatory genes, and is also detectable in brains with frequent neuritic plaques. Next, we tested these findings in APOE knock-in mice exposed to acute (lipopolysaccharide challenge) and chronic (cerebral β-amyloidosis) insults and found that these mice partially recapitulate human APOE-linked expression patterns. Thus, the APOEε4 allele might prime microglia towards a phagocytic and proinflammatory state through an APOE–TREM2–TYROBP axis in normal aging as well as in Alzheimer’s disease. The authors found that the Alzheimer’s disease-linked APOEε4 allele may prime microglia towards a phagocytic and pro-inflammatory state in the normal aging brain, even before Alzheimer’s amyloid plaques and neurofibrillary tangles develop." @default.
- W3206683634 created "2021-10-25" @default.
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- W3206683634 date "2021-10-11" @default.
- W3206683634 modified "2023-10-14" @default.
- W3206683634 title "Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer’s disease" @default.
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- W3206683634 cites W1958554455 @default.
- W3206683634 cites W1966895399 @default.
- W3206683634 cites W1969050262 @default.
- W3206683634 cites W1976722506 @default.
- W3206683634 cites W1987219048 @default.
- W3206683634 cites W1993676790 @default.
- W3206683634 cites W1995111570 @default.
- W3206683634 cites W2001618696 @default.
- W3206683634 cites W2033105784 @default.
- W3206683634 cites W2045964495 @default.
- W3206683634 cites W2046937680 @default.
- W3206683634 cites W2048970708 @default.
- W3206683634 cites W2052742260 @default.
- W3206683634 cites W2059996790 @default.
- W3206683634 cites W2084687969 @default.
- W3206683634 cites W2087243986 @default.
- W3206683634 cites W2096963202 @default.
- W3206683634 cites W2107281222 @default.
- W3206683634 cites W2124490243 @default.
- W3206683634 cites W2127101809 @default.
- W3206683634 cites W2128613449 @default.
- W3206683634 cites W2142943752 @default.
- W3206683634 cites W2146512944 @default.
- W3206683634 cites W2146729934 @default.
- W3206683634 cites W2156821568 @default.
- W3206683634 cites W2191292005 @default.
- W3206683634 cites W2193492588 @default.
- W3206683634 cites W2314634699 @default.
- W3206683634 cites W2337275183 @default.
- W3206683634 cites W2339534121 @default.
- W3206683634 cites W2592518050 @default.
- W3206683634 cites W2618794795 @default.
- W3206683634 cites W2619332462 @default.
- W3206683634 cites W2622807556 @default.
- W3206683634 cites W2625865615 @default.
- W3206683634 cites W2754890392 @default.
- W3206683634 cites W2756959977 @default.
- W3206683634 cites W2763928642 @default.
- W3206683634 cites W2765738520 @default.
- W3206683634 cites W2774718202 @default.
- W3206683634 cites W2775642640 @default.
- W3206683634 cites W2783582599 @default.
- W3206683634 cites W2790949074 @default.
- W3206683634 cites W2795435173 @default.
- W3206683634 cites W2805798400 @default.
- W3206683634 cites W2885498250 @default.
- W3206683634 cites W2889790826 @default.
- W3206683634 cites W2894623022 @default.
- W3206683634 cites W2895288124 @default.
- W3206683634 cites W2896393831 @default.
- W3206683634 cites W2898757824 @default.
- W3206683634 cites W2913240459 @default.
- W3206683634 cites W2916749909 @default.
- W3206683634 cites W2942678593 @default.
- W3206683634 cites W2950886245 @default.
- W3206683634 cites W2953373572 @default.
- W3206683634 cites W2963077106 @default.
- W3206683634 cites W2965401191 @default.
- W3206683634 cites W2969396388 @default.
- W3206683634 cites W2972433621 @default.
- W3206683634 cites W2980270906 @default.
- W3206683634 cites W2980668035 @default.
- W3206683634 cites W2990312754 @default.
- W3206683634 cites W2991414673 @default.
- W3206683634 cites W2997916102 @default.
- W3206683634 cites W2998795963 @default.
- W3206683634 cites W3003860558 @default.
- W3206683634 cites W3011658331 @default.
- W3206683634 cites W3022473425 @default.
- W3206683634 cites W3034536401 @default.
- W3206683634 cites W3043048574 @default.
- W3206683634 cites W3043108667 @default.
- W3206683634 cites W3044901278 @default.
- W3206683634 cites W3058283092 @default.
- W3206683634 cites W3087075244 @default.
- W3206683634 cites W3111203418 @default.
- W3206683634 cites W3112334124 @default.
- W3206683634 cites W3136651487 @default.
- W3206683634 cites W3211563941 @default.
- W3206683634 doi "https://doi.org/10.1038/s43587-021-00123-6" @default.
- W3206683634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36199750" @default.
- W3206683634 hasPublicationYear "2021" @default.