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- W3206683779 abstract "Background: Non-celiac gluten sensitivity (NCGS) is a syndrome that is related to the ingestion of gluten-containing food. In the current study we developed and validated a NCGS rat model. Materials and Methods: Wistar rats were divided into 2 groups: control group (receiving 0.02 M acetic acid solution) and gliadin group (receiving 1.5 mg/g of body weight of gliadin in acetic acid solution). Rats received its treatment by intra-gastric gavage on postnatal day 2, then three times a week for 6 weeks. Animals were assessed for weight changes, intestinal permeability, histology, inflammatory cytokines, and anti-gliadin antibodies (AGA). Intestinal permeability was evaluated 24 h prior to sacrifice by administering a lactulose/mannitol solution (500/250 mg/kg respectively), and collecting urine for 24 h. For histological examination, small intestines were collected, fixed, and stained with hematoxylin and eosin. Intestinal gene expression of cytochrome P450 (CYP 3a62, CYP 3a9/18) and uptake transporters, breast cancer resistance protein (ABCG2), and P-glycoprotein (MDR1a) were evaluated using qRT-PCR. Blood was collected for measurement of totalanti-gliadin antibodies (AGA), anti-gliadin immunoglobulins A and M (AGA-IgA and AGA-IgM), and pro-inflammatory cytokines. Results: As compared to control, the gliadin group had lower body weight, increased intestinal permeability (p<0.05); mild villous atrophy, increased intraepithelial lymphocytes, mild inflammation; increases in total AGA and AGA-IgM, increased gene expression of pro-inflammatory cytokines, IL-6, TNF-α, and IFN-γ, by 94%, 33%, and 46% (p < 0.05) and altered gene expressions of CYP450 and transporters. Conclusions: This model closely mimics the pathological and inflammatory characteristics of NCGS, and could be used to test new pharmacological treatments for this syndrome." @default.
- W3206683779 created "2021-10-25" @default.
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- W3206683779 date "2021-01-01" @default.
- W3206683779 modified "2023-10-18" @default.
- W3206683779 title "Development and Validation of a Gliadin Induced Intestinal Enteropathy Rat Model of Non-Celiac Gluten Sensitivity" @default.
- W3206683779 doi "https://doi.org/10.26502/fjppr.045" @default.
- W3206683779 hasPublicationYear "2021" @default.
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