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- W3206686128 abstract "This study aimed to measure health-related quality of life (HRQOL) in children and adolescents with tuberous sclerosis complex (TSC) and quality of life (QOL) and depressive symptoms among caregivers.Adequate metrics were used to assess HRQOL in children and adolescents with TSC (4-18 years, KINDLR) as well as QOL (EQ-5D) and symptoms of depression (BDI-II) among caregivers. Predictors for reduced HRQOL and depressive symptoms were identified by variance analysis, ordinal regression, and bivariate correlation.The mean HRQOL score was 67.9 ± 12.7, and significantly lower values were associated with increasing age, attending special needs education, TSC-associated psychiatric symptoms, and drug-related adverse events. The mean QOL of caregivers was 85.4 ± 15.7, and caregiver's sex, TSC mutation locus, familial TSC clustering, special needs education, degree of disability, care dependency, presence of TSC-associated psychiatric symptoms, and TSC severity were significant predictors of lower QOL. Depressive symptoms were identified in 45.7% of caregivers, associated with female sex of the caregiver, familial TSC clustering, special needs education, and presence of TSC-associated psychiatric symptoms of the child. Multivariate regression analysis revealed adolescence and drug-related adverse events as significant predictors for lower HRQOL in TSC children, and TSC2 variants predicted lower QOL and depressive symptoms in caregivers.Compared with other chronic diseases, such as headache, diabetes or obesity, children with TSC have significantly lower HRQOL, which further decreases during adolescence. A decreased HRQOL of patients correlates with a lower QOL and increased symptoms of depression of their caregivers. These results may improve the comprehensive therapy and care of children and adolescents with TSC and their families and caregivers.DRKS, DRKS00016045. Registered 01 March 2019, http://www.drks.de/DRKS00016045." @default.
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- W3206686128 date "2021-11-01" @default.
- W3206686128 modified "2023-10-15" @default.
- W3206686128 title "Health-related quality of life in children and adolescents with tuberous sclerosis complex and their caregivers: A multicentre cohort study from Germany" @default.
- W3206686128 cites W1540403255 @default.
- W3206686128 cites W1574898460 @default.
- W3206686128 cites W1606961096 @default.
- W3206686128 cites W1899672831 @default.
- W3206686128 cites W1970917345 @default.
- W3206686128 cites W1982992093 @default.
- W3206686128 cites W1984730073 @default.
- W3206686128 cites W1992246305 @default.
- W3206686128 cites W2005336684 @default.
- W3206686128 cites W2007706875 @default.
- W3206686128 cites W2008032479 @default.
- W3206686128 cites W2020993265 @default.
- W3206686128 cites W2024122126 @default.
- W3206686128 cites W2060884559 @default.
- W3206686128 cites W2064350862 @default.
- W3206686128 cites W2071339371 @default.
- W3206686128 cites W2090177549 @default.
- W3206686128 cites W2094932943 @default.
- W3206686128 cites W2100428079 @default.
- W3206686128 cites W2112730583 @default.
- W3206686128 cites W2113741689 @default.
- W3206686128 cites W2116180053 @default.
- W3206686128 cites W2118523264 @default.
- W3206686128 cites W2124662662 @default.
- W3206686128 cites W2126467306 @default.
- W3206686128 cites W2151593772 @default.
- W3206686128 cites W2153836018 @default.
- W3206686128 cites W2169940153 @default.
- W3206686128 cites W2268219510 @default.
- W3206686128 cites W2277986107 @default.
- W3206686128 cites W2279074305 @default.
- W3206686128 cites W2301413839 @default.
- W3206686128 cites W2311849209 @default.
- W3206686128 cites W2415418665 @default.
- W3206686128 cites W2476917074 @default.
- W3206686128 cites W2488978600 @default.
- W3206686128 cites W2550532449 @default.
- W3206686128 cites W2591105866 @default.
- W3206686128 cites W2592509339 @default.
- W3206686128 cites W2594644573 @default.
- W3206686128 cites W2599076725 @default.
- W3206686128 cites W2605721278 @default.
- W3206686128 cites W2607428587 @default.
- W3206686128 cites W2748168699 @default.
- W3206686128 cites W2763793094 @default.
- W3206686128 cites W2766999669 @default.
- W3206686128 cites W2768235793 @default.
- W3206686128 cites W2791298553 @default.
- W3206686128 cites W2796161552 @default.
- W3206686128 cites W2803654588 @default.
- W3206686128 cites W2844743642 @default.
- W3206686128 cites W2884747888 @default.
- W3206686128 cites W2892056276 @default.
- W3206686128 cites W2912906402 @default.
- W3206686128 cites W2918401909 @default.
- W3206686128 cites W2918466418 @default.
- W3206686128 cites W2934353765 @default.