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- W3206700539 abstract "Alzheimer's disease (AD), a neurodegenerative disease, is the leading cause of dementia. Sesamol is a lignan extracted from sesame oil and has been found to exert neuroprotective effects. The present study aimed to investigate the neuroprotective effects of sesamol on APPswe/PS1dE9 transgenic AD mice. The AD mice were fed with a diet supplemented with sesamol (0.075 w/w %). Sesamol treatment improved spatial memory and learning ability in AD mice, improved neuronal damage, and decreased Aβ accumulation. Sesamol protected the synaptic ultrastructure and inhibited neuroinflammatory responses in the brain of AD mice. Sesamol also significantly inhibited the overactivated microglia and reduced the overexpression of TNF-α and IL-1β in the brain of AD mice. Notably, sesamol reshaped gut microbiota by significantly decreasing the relative abundance of Helicobacter hepaticus, Clostridium, and Bacillaceae, enhancing the relative abundance of Rikenellaceae and Bifidobacterium in AD mice. It has been found that sesamol protected the gut barrier integrity and prevented the LPS leakage into the serum. Importantly, sesamol remarkably enhanced the content of SCFAs, including acetate, propionate, isobutyrate, butyrate, and valerate, in AD mice. Correlation analysis indicated that there was a strong correlation between the levels of SCFAs and cognitive functions. These results demonstrated that sesamol attenuated AD-related cognitive dysfunction and neuroinflammatory responses, which could be partly explained by its role in mediating the gut microbe-SCFA-brain axis. Thus, sesamol is a promising nutritional intervention strategy to prevent AD via the microbiota-gut-brain axis." @default.
- W3206700539 created "2021-10-25" @default.
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- W3206700539 date "2021-10-20" @default.
- W3206700539 modified "2023-10-17" @default.
- W3206700539 title "Sesamol Attenuates Amyloid Peptide Accumulation and Cognitive Deficits in APP/PS1 Mice: The Mediating Role of the Gut–Brain Axis" @default.
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- W3206700539 cites W2004405731 @default.
- W3206700539 cites W2015649393 @default.
- W3206700539 cites W2015675928 @default.
- W3206700539 cites W2033789918 @default.
- W3206700539 cites W2046328818 @default.
- W3206700539 cites W2090536925 @default.
- W3206700539 cites W2096407545 @default.
- W3206700539 cites W2108335346 @default.
- W3206700539 cites W2135732933 @default.
- W3206700539 cites W2155770880 @default.
- W3206700539 cites W2156326104 @default.
- W3206700539 cites W2273641546 @default.
- W3206700539 cites W2295859050 @default.
- W3206700539 cites W2338435075 @default.
- W3206700539 cites W2413138195 @default.
- W3206700539 cites W2460405435 @default.
- W3206700539 cites W2548933161 @default.
- W3206700539 cites W2550260150 @default.
- W3206700539 cites W2558599134 @default.
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- W3206700539 cites W2804939759 @default.
- W3206700539 cites W2807779740 @default.
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- W3206700539 cites W2898150668 @default.
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- W3206700539 cites W2909355242 @default.
- W3206700539 cites W2917585368 @default.
- W3206700539 cites W2945345995 @default.
- W3206700539 cites W2946140916 @default.
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- W3206700539 cites W3008197203 @default.
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- W3206700539 cites W3015811947 @default.
- W3206700539 cites W3017160392 @default.
- W3206700539 cites W3022765794 @default.
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- W3206700539 doi "https://doi.org/10.1021/acs.jafc.1c04687" @default.
- W3206700539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34669408" @default.
- W3206700539 hasPublicationYear "2021" @default.
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