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• W3206737108 abstract "Tranexamic Acid (TA) is a clinically used antifibrinolytic that acts as a lysine mimetic to block binding of Plasminogen with Plasminogen activators, preventing conversion of Plasminogen to its proteolytically activated form, Plasmin. Previous studies suggested that TA may exhibit anticancer activity by blockade of extracellular Plasmin formation. Plasmin-mediated cleavage of the CDCP1 protein may increase its oncogenic functions through several downstream pathways. Results presented herein demonstrate that TA blocks Plasmin-mediated excision of the extracellular domain of the oncoprotein CDCP1. In vitro studies indicate that TA reduces the viability of a broad array of human and murine cancer cell lines, and breast tumor growth studies demonstrate that TA reduces cancer growth in vivo. Based on the ability of TA to mimic lysine and arginine, we hypothesized that TA may perturb multiple processes that involve Lys/Arg-rich protein sequences, and that TA may alter intracellular signaling pathways in addition to blocking extracellular Plasmin production. Indeed, TA-mediated suppression of tumor cell viability is associated with multiple biochemical actions, including inhibition of protein synthesis, reduced activating phosphorylation of STAT3 and S6K1, decreased expression of the MYC oncoprotein, and suppression of Lys acetylation. These findings suggest that TA or TA analogs may serve as lead compounds and inspire the production of new classes of anticancer agents that function by mimicking Lys and Arg." @default.
• W3206737108 created "2021-10-25" @default.
• W3206737108 creator A5014754069 @default.
• W3206737108 creator A5020449422 @default.
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• W3206737108 creator A5037116125 @default.
• W3206737108 creator A5066902085 @default.
• W3206737108 creator A5074199486 @default.
• W3206737108 creator A5086844682 @default.
• W3206737108 date "2021-10-17" @default.
• W3206737108 modified "2023-09-27" @default.
• W3206737108 title "Repurposing Tranexamic Acid as an Anticancer Agent" @default.
• W3206737108 cites W1480943248 @default.
• W3206737108 cites W1507844320 @default.
• W3206737108 cites W1516157468 @default.
• W3206737108 cites W1537196537 @default.
• W3206737108 cites W1593770810 @default.
• W3206737108 cites W1862691835 @default.
• W3206737108 cites W1963605665 @default.
• W3206737108 cites W1964211866 @default.
• W3206737108 cites W1965655656 @default.
• W3206737108 cites W1976220376 @default.
• W3206737108 cites W1983699546 @default.
• W3206737108 cites W1993653149 @default.
• W3206737108 cites W1993784298 @default.
• W3206737108 cites W1994339372 @default.
• W3206737108 cites W1999223726 @default.
• W3206737108 cites W2003885552 @default.
• W3206737108 cites W2004909339 @default.
• W3206737108 cites W2004923643 @default.
• W3206737108 cites W2008141356 @default.
• W3206737108 cites W2010059857 @default.
• W3206737108 cites W2022045958 @default.
• W3206737108 cites W2024628491 @default.
• W3206737108 cites W2030303876 @default.
• W3206737108 cites W2035915355 @default.
• W3206737108 cites W2041205704 @default.
• W3206737108 cites W2044634502 @default.
• W3206737108 cites W2049828754 @default.
• W3206737108 cites W2050930989 @default.
• W3206737108 cites W2051890299 @default.
• W3206737108 cites W2054584993 @default.
• W3206737108 cites W2058012673 @default.
• W3206737108 cites W2059641703 @default.
• W3206737108 cites W2064117044 @default.
• W3206737108 cites W2068935459 @default.
• W3206737108 cites W2072876326 @default.
• W3206737108 cites W2076326092 @default.
• W3206737108 cites W2081674135 @default.
• W3206737108 cites W2089340521 @default.
• W3206737108 cites W2092629732 @default.
• W3206737108 cites W2093199938 @default.
• W3206737108 cites W2097731453 @default.
• W3206737108 cites W2100799839 @default.
• W3206737108 cites W2106044081 @default.
• W3206737108 cites W2107877605 @default.
• W3206737108 cites W2108564378 @default.
• W3206737108 cites W2117809223 @default.
• W3206737108 cites W2118589813 @default.
• W3206737108 cites W2136530078 @default.
• W3206737108 cites W2145682411 @default.
• W3206737108 cites W2154441831 @default.
• W3206737108 cites W2160226692 @default.
• W3206737108 cites W2178062928 @default.
• W3206737108 cites W2285494695 @default.
• W3206737108 cites W2407470748 @default.
• W3206737108 cites W2411104338 @default.
• W3206737108 cites W2414923136 @default.
• W3206737108 cites W2416623257 @default.
• W3206737108 cites W2443409378 @default.
• W3206737108 cites W2484764913 @default.
• W3206737108 cites W2491281408 @default.
• W3206737108 cites W2512636085 @default.
• W3206737108 cites W2519764694 @default.
• W3206737108 cites W2533676865 @default.
• W3206737108 cites W2594912875 @default.
• W3206737108 cites W2758743773 @default.
• W3206737108 cites W2767059647 @default.
• W3206737108 cites W2780201866 @default.
• W3206737108 cites W2786778447 @default.
• W3206737108 cites W2793664528 @default.
• W3206737108 cites W2802014225 @default.
• W3206737108 cites W2804022490 @default.
• W3206737108 cites W2893646631 @default.
• W3206737108 cites W2914550798 @default.
• W3206737108 cites W2919162898 @default.
• W3206737108 cites W2920947647 @default.
• W3206737108 cites W2926343247 @default.
• W3206737108 cites W2947726514 @default.
• W3206737108 cites W2952522854 @default.
• W3206737108 cites W2966416050 @default.
• W3206737108 cites W2995389400 @default.
• W3206737108 cites W3011747304 @default.
• W3206737108 cites W3118374649 @default.
• W3206737108 cites W3118711948 @default.
• W3206737108 cites W3133371349 @default.
• W3206737108 cites W3133924569 @default.

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