Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206737328> ?p ?o ?g. }
- W3206737328 abstract "Thermogenic brown and beige adipocytes might open up new strategies in combating obesity. Recent studies in rodents and humans have indicated that these adipocytes release cytokines, termed “batokines”. Irisin was discovered as a polypeptide regulator of beige adipocytes released by myocytes, primarily during exercise. We performed global RNA sequencing on adipocytes derived from human subcutaneous and deep-neck precursors, which were differentiated in the presence or absence of irisin. Irisin did not exert an effect on the expression of characteristic thermogenic genes, while upregulated genes belonging to various cytokine signaling pathways. Out of the several upregulated cytokines, CXCL1 , the highest upregulated, was released throughout the entire differentiation period, and predominantly by differentiated adipocytes. Deep-neck area tissue biopsies also showed a significant release of CXCL1 during 24 h irisin treatment. Gene expression data indicated upregulation of the NFκB pathway upon irisin treatment, which was validated by an increase of p50 and decrease of IκBα protein level, respectively. Continuous blocking of the NFκB pathway, using a cell permeable inhibitor of NFκB nuclear translocation, significantly reduced CXCL1 release. The released CXCL1 exerted a positive effect on the adhesion of endothelial cells. Together, our findings demonstrate that irisin stimulates the release of a novel adipokine, CXCL1, via upregulation of NFκB pathway in neck area derived adipocytes, which might play an important role in improving tissue vascularization." @default.
- W3206737328 created "2021-10-25" @default.
- W3206737328 creator A5014742619 @default.
- W3206737328 creator A5027682703 @default.
- W3206737328 creator A5043533006 @default.
- W3206737328 creator A5050239628 @default.
- W3206737328 creator A5055069210 @default.
- W3206737328 creator A5061320307 @default.
- W3206737328 creator A5081752332 @default.
- W3206737328 creator A5082401067 @default.
- W3206737328 creator A5082505630 @default.
- W3206737328 creator A5082542719 @default.
- W3206737328 creator A5083550588 @default.
- W3206737328 creator A5088305940 @default.
- W3206737328 date "2021-10-11" @default.
- W3206737328 modified "2023-10-14" @default.
- W3206737328 title "Irisin Stimulates the Release of CXCL1 From Differentiating Human Subcutaneous and Deep-Neck Derived Adipocytes via Upregulation of NFκB Pathway" @default.
- W3206737328 cites W1537001687 @default.
- W3206737328 cites W1595439970 @default.
- W3206737328 cites W1618991848 @default.
- W3206737328 cites W1843349889 @default.
- W3206737328 cites W1886130798 @default.
- W3206737328 cites W1891518777 @default.
- W3206737328 cites W1923336662 @default.
- W3206737328 cites W1931609017 @default.
- W3206737328 cites W1963499117 @default.
- W3206737328 cites W1965079305 @default.
- W3206737328 cites W1970595265 @default.
- W3206737328 cites W1972378250 @default.
- W3206737328 cites W1984095802 @default.
- W3206737328 cites W1986602268 @default.
- W3206737328 cites W2000559235 @default.
- W3206737328 cites W2005464097 @default.
- W3206737328 cites W2005827500 @default.
- W3206737328 cites W2008150005 @default.
- W3206737328 cites W2013900763 @default.
- W3206737328 cites W2020696631 @default.
- W3206737328 cites W2022352721 @default.
- W3206737328 cites W2027753197 @default.
- W3206737328 cites W2040328785 @default.
- W3206737328 cites W2055347890 @default.
- W3206737328 cites W2075496997 @default.
- W3206737328 cites W2075808770 @default.
- W3206737328 cites W2085397620 @default.
- W3206737328 cites W2112076976 @default.
- W3206737328 cites W2115235864 @default.
- W3206737328 cites W2121921343 @default.
- W3206737328 cites W2122069979 @default.
- W3206737328 cites W2132358997 @default.
- W3206737328 cites W2134630622 @default.
- W3206737328 cites W2137485611 @default.
- W3206737328 cites W2138207763 @default.
- W3206737328 cites W2144814682 @default.
- W3206737328 cites W2146625096 @default.
- W3206737328 cites W2147907319 @default.
- W3206737328 cites W2148345765 @default.
- W3206737328 cites W2163644328 @default.
- W3206737328 cites W2167344369 @default.
- W3206737328 cites W2169456326 @default.
- W3206737328 cites W2182948109 @default.
- W3206737328 cites W2218179671 @default.
- W3206737328 cites W2252280064 @default.
- W3206737328 cites W2289637790 @default.
- W3206737328 cites W2479660582 @default.
- W3206737328 cites W2508257164 @default.
- W3206737328 cites W2518904228 @default.
- W3206737328 cites W2605432571 @default.
- W3206737328 cites W2621034315 @default.
- W3206737328 cites W2736913806 @default.
- W3206737328 cites W2755054644 @default.
- W3206737328 cites W2768402021 @default.
- W3206737328 cites W2794683930 @default.
- W3206737328 cites W2883005875 @default.
- W3206737328 cites W2886566773 @default.
- W3206737328 cites W2889874748 @default.
- W3206737328 cites W2905310978 @default.
- W3206737328 cites W2913539314 @default.
- W3206737328 cites W2915355067 @default.
- W3206737328 cites W2917027985 @default.
- W3206737328 cites W2938595851 @default.
- W3206737328 cites W2967123345 @default.
- W3206737328 cites W2968499785 @default.
- W3206737328 cites W3017230513 @default.
- W3206737328 cites W3023114199 @default.
- W3206737328 cites W3035733140 @default.
- W3206737328 cites W3080905177 @default.
- W3206737328 cites W3084210226 @default.
- W3206737328 cites W3100400639 @default.
- W3206737328 cites W3124550675 @default.
- W3206737328 cites W3128660968 @default.
- W3206737328 doi "https://doi.org/10.3389/fcell.2021.737872" @default.
- W3206737328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8542801" @default.
- W3206737328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34708041" @default.
- W3206737328 hasPublicationYear "2021" @default.
- W3206737328 type Work @default.
- W3206737328 sameAs 3206737328 @default.
- W3206737328 citedByCount "8" @default.
- W3206737328 countsByYear W32067373282021 @default.
- W3206737328 countsByYear W32067373282022 @default.
- W3206737328 countsByYear W32067373282023 @default.