FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206739174> ?p ?o ?g. }

• W3206739174 abstract "Background & Aims: The understanding of the relationship between exposure to carcinogenic vinyl chloride (VCM) and ethylene dichloride (EDC) and liver fibrosis is limited. This study aimed to investigate the associations between the urinary metabolite levels of VCM and EDC and the risk of fibrosis in residents living near a petrochemical complex. Approach & Results: Our study comprised 447 adult residents of two townships with questionnaire survey and health examination near the largest petrochemical complex in Taiwan. The urinary levels of thiodiglycolic acid (TdGA), the metabolite of VCM and EDC, were detected in study subjects. We utilized fibrosis-4 (FIB-4) as the liver fibrosis index. Adjusted generalized linear and logistic regression models were applied to evaluate the associations between those exposure and the risk of fibrosis. The subjects living in the closer township had significantly higher TdGA levels than those living in the more distant (269.6 ±200.7 vs. 199.2±164.7 μg/g creatinine). It showed that TdGA levels were 6.51 μg/g creatinine lower 1 km away from the emission source of the complex after adjusting for confounding factors. It demonstrated that the subjects with the highest TdGA levels (>343.3 μg/g creatinine) had a significantly higher risk of abnormal FIB-4 (OR=2.09; 95% CI: 1.17, 3.77), and those with higher TdGA levels (232.7 to 343.3 μg/g creatinine) had a marginally higher risk of abnormal FIB-4 (OR=1.65; 95% CI: 0.94, 2.90). Conclusion: The residents living closer to the VCM/PVC plant in the complex had higher urinary TdGA levels, which were significantly associated with the risk of fibrosis. This confirmed that the EDC and VCM potentially emitted from the petrochemical industry may have an impact on the liver health of nearby residents.Funding Statement: This research was funded by a grant from the Changhua County Public Health Bureau in Taiwan (grant number 1040723). The study was also funded by the Ministry of Science and Technology in Taiwan (grant number MOST 107-3017-F-002-003, MOST 108-3017-F-002-001) and Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education in Taiwan (grant numbers NTU-107L9003, NTU380 108L9003).Declaration of Interests: The authors declare no competing interests.Ethics Approval Statement: This study was approved by the Research Ethics Committee of the National Health Research Institutes in Taiwan, and written informed consent forms were signed by each subject." @default.
• W3206739174 created "2021-10-25" @default.
• W3206739174 creator A5033700870 @default.
• W3206739174 creator A5045765484 @default.
• W3206739174 creator A5047348702 @default.
• W3206739174 creator A5067634195 @default.
• W3206739174 creator A5089998671 @default.
• W3206739174 date "2020-01-01" @default.
• W3206739174 modified "2023-09-23" @default.
• W3206739174 title "Liver Fibrosis Associated with Potential Vinyl Chloride and Ethylene Dichloride Exposure from the Petrochemical Industry" @default.
• W3206739174 doi "https://doi.org/10.2139/ssrn.3539692" @default.
• W3206739174 hasPublicationYear "2020" @default.
• W3206739174 type Work @default.
• W3206739174 sameAs 3206739174 @default.
• W3206739174 citedByCount "0" @default.
• W3206739174 crossrefType "journal-article" @default.
• W3206739174 hasAuthorship W3206739174A5033700870 @default.
• W3206739174 hasAuthorship W3206739174A5045765484 @default.
• W3206739174 hasAuthorship W3206739174A5047348702 @default.
• W3206739174 hasAuthorship W3206739174A5067634195 @default.
• W3206739174 hasAuthorship W3206739174A5089998671 @default.
• W3206739174 hasConcept C126322002 @default.
• W3206739174 hasConcept C151956035 @default.
• W3206739174 hasConcept C15920480 @default.
• W3206739174 hasConcept C178790620 @default.
• W3206739174 hasConcept C185592680 @default.
• W3206739174 hasConcept C2777477808 @default.
• W3206739174 hasConcept C2780306776 @default.
• W3206739174 hasConcept C2780559512 @default.
• W3206739174 hasConcept C2781460079 @default.
• W3206739174 hasConcept C33070731 @default.
• W3206739174 hasConcept C521977710 @default.
• W3206739174 hasConcept C71924100 @default.
• W3206739174 hasConcept C77350462 @default.
• W3206739174 hasConcept C77411442 @default.
• W3206739174 hasConcept C86803240 @default.
• W3206739174 hasConcept C99454951 @default.
• W3206739174 hasConceptScore W3206739174C126322002 @default.
• W3206739174 hasConceptScore W3206739174C151956035 @default.
• W3206739174 hasConceptScore W3206739174C15920480 @default.
• W3206739174 hasConceptScore W3206739174C178790620 @default.
• W3206739174 hasConceptScore W3206739174C185592680 @default.
• W3206739174 hasConceptScore W3206739174C2777477808 @default.
• W3206739174 hasConceptScore W3206739174C2780306776 @default.
• W3206739174 hasConceptScore W3206739174C2780559512 @default.
• W3206739174 hasConceptScore W3206739174C2781460079 @default.
• W3206739174 hasConceptScore W3206739174C33070731 @default.
• W3206739174 hasConceptScore W3206739174C521977710 @default.
• W3206739174 hasConceptScore W3206739174C71924100 @default.
• W3206739174 hasConceptScore W3206739174C77350462 @default.
• W3206739174 hasConceptScore W3206739174C77411442 @default.
• W3206739174 hasConceptScore W3206739174C86803240 @default.
• W3206739174 hasConceptScore W3206739174C99454951 @default.
• W3206739174 hasLocation W32067391741 @default.
• W3206739174 hasOpenAccess W3206739174 @default.
• W3206739174 hasPrimaryLocation W32067391741 @default.
• W3206739174 hasRelatedWork W11869054 @default.
• W3206739174 hasRelatedWork W13695452 @default.
• W3206739174 hasRelatedWork W17209738 @default.
• W3206739174 hasRelatedWork W17728588 @default.
• W3206739174 hasRelatedWork W18975854 @default.
• W3206739174 hasRelatedWork W1968912 @default.
• W3206739174 hasRelatedWork W20378944 @default.
• W3206739174 hasRelatedWork W5264710 @default.
• W3206739174 hasRelatedWork W7847161 @default.
• W3206739174 hasRelatedWork W19359277 @default.
• W3206739174 isParatext "false" @default.
• W3206739174 isRetracted "false" @default.
• W3206739174 magId "3206739174" @default.
• W3206739174 workType "article" @default.