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• W3206741391 abstract "Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19. Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus. Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (&gt;22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO 2 ) &lt;92%, blood pressure (BP) (systolic BP &lt;90 mmHg and diastolic BP &lt;60 mmHg), Glasgow Coma Scale (GCS) &lt;15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine &gt;1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1–11.8%); intermediate-risk group (24.8–53.8%); and high-risk-group (58.3–100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO 2 , decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis. Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate." @default.
• W3206741391 created "2021-10-25" @default.
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• W3206741391 date "2021-10-14" @default.
• W3206741391 modified "2023-10-18" @default.
• W3206741391 title "Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score" @default.
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• W3206741391 doi "https://doi.org/10.3389/fmed.2021.728102" @default.
• W3206741391 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8603931" @default.
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