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- W3206770149 abstract "Sex plays a role in determining birthweight, with male babies heavier on average than females. However, not all growth standards are sex-specific; some use mean birthweight for both male and females. We aimed to identify the proportion of infants would be re-classified if sex-specific charts were used, and if this had a measurable impact on perinatal outcomes. Retrospective cohort study including all infants born in Victoria, Australia, from 2005-2015 (529,261 cases). We applied GROW centiles, either adjusted or not adjusted for fetal sex. We compared overall SGA populations, populations of males considered small by sex-specific charts only, and females considered small by unadjusted charts only. Of those <10th centile by unadjusted charts, 39.6% were male, and 60.5% female. Using sex-specific charts, 50.3% of those <10th centile were male and 49.7% female. 19.2% of females that were SGA according to unadjusted charts were reclassified as average for gestational age (AGA) using sex-specific charts. These female newborns were not at increased risk of stillbirth or other poor outcomes compared with an infant AGA by both charts (AGAall), but were at greater risk of being iatrogenically delivered on suspicion of growth restriction (RR 4.90, 95%CI 4.39 – 5.48). Sex-specific charts increased the male SGA cohort by 25%. Compared to the AGAall infants, these newly SGA male newborns were at greater risk of stillbirth (RR 1.94, 95%CI 1.30-2.90), combined perinatal mortality (RR 1.80, 95%CI 1.26 – 2.57), NICU admissions (RR 1.38, 95%CI 1.12-1.71), Apgars<7 at 5 minutes (RR 1.40, 95%CI 1.25-1.56) and emergency Caesarean sections (RR 1.12, 95%CI 1.06-1.18). Sex-specific growth standards improve correlation with perinatal outcomes, over growth standards unadjusted for fetal sex. They newly classify a high risk cohort of male infants as SGA, and exclude a cohort of female infants, whose risk is no greater than an appropriately grown infant." @default.
- W3206770149 created "2021-10-25" @default.
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- W3206770149 date "2021-10-01" @default.
- W3206770149 modified "2023-09-26" @default.
- W3206770149 title "OC04.07: Adjusting growth standards for fetal sex better correlates with perinatal morbidity and mortality: an Australian state‐wide population study" @default.
- W3206770149 doi "https://doi.org/10.1002/uog.23798" @default.
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