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- W3206792016 abstract "Previous studies showed reorganised and/or altered activity in the primary sensorimotor cortex after a spinal cord injury (SCI), suggested to reflect abnormal processing. However, little is known about whether somatotopically specific representations can be activated despite reduced or absent afferent hand inputs. In this observational study, we used functional MRI and a (attempted) finger movement task in tetraplegic patients to characterise the somatotopic hand layout in primary somatosensory cortex. We further used structural MRI to assess spared spinal tissue bridges. We found that somatotopic hand representations can be activated through attempted finger movements in the absence of sensory and motor hand functioning, and no spared spinal tissue bridges. Such preserved hand somatotopy could be exploited by rehabilitation approaches that aim to establish new hand-brain functional connections after SCI (e.g. neuroprosthetics). However, over years since SCI the hand representation somatotopy deteriorated, suggesting that somatotopic hand representations are more easily targeted within the first years after SCI." @default.
- W3206792016 created "2021-10-25" @default.
- W3206792016 creator A5020372477 @default.
- W3206792016 creator A5037106114 @default.
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- W3206792016 creator A5057927255 @default.
- W3206792016 creator A5069418588 @default.
- W3206792016 date "2021-10-19" @default.
- W3206792016 modified "2023-10-16" @default.
- W3206792016 title "Finger somatotopy is preserved after tetraplegia but deteriorates over time" @default.
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- W3206792016 doi "https://doi.org/10.7554/elife.67713" @default.
- W3206792016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8575460" @default.