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- W3206792105 abstract "We describe a microporous plasmonic nanoreactor to carry out designed near-infrared (NIR)-driven photothermal cyclizations inside living cells. As a proof of concept, we chose an intramolecular cyclization that is based on the nucleophilic attack of a pyridine onto an electrophilic carbon, a process that requires high activation energies and is typically achieved in bulk solution by heating at ∼90 °C. The core-shell nanoreactor (NR) has been designed to include a gold nanostar core, which is embedded within a metal-organic framework (MOF) based on a polymer-stabilized zeolitic imidazole framework-8 (ZIF-8). Once accumulated inside living cells, the MOF-based cloak of NRs allows an efficient diffusion of reactants into the plasmonic chamber, where they undergo the transformation upon near-IR illumination. The photothermal-driven reaction enables the intracellular generation of cyclic fluorescent products that can be tracked using fluorescence microscopy. The strategy may find different type of applications, such as for the spatio-temporal activation of prodrugs." @default.
- W3206792105 created "2021-10-25" @default.
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- W3206792105 date "2021-10-18" @default.
- W3206792105 modified "2023-10-16" @default.
- W3206792105 title "Plasmonic-Assisted Thermocyclizations in Living Cells Using Metal–Organic Framework Based Nanoreactors" @default.
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- W3206792105 doi "https://doi.org/10.1021/acsnano.1c07983" @default.
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