Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206795340> ?p ?o ?g. }
- W3206795340 endingPage "1060" @default.
- W3206795340 startingPage "1051" @default.
- W3206795340 abstract "The mechanisms through which drug-cue-induced negative affective states are involved in relapse have not been defined. We tested the hypothesis that in individuals having developed a dorsolateral striatum (DLS)-dependent cue-controlled cocaine-seeking habit, the loss of the opportunity to enact the drug-seeking response during abstinence results in an urge to act that exacerbates relapse severity mediated by negative urgency.Eighty-seven male Sprague Dawley rats were trained to seek cocaine under the influence of the conditioned reinforcing properties of drug-paired cues or not. We investigated whether the tendency to relapse depended on the aversive state of withdrawal or instead on the loss of opportunity to perform the ingrained drug-seeking response after periods of abstinence. The striatal locus of control over cocaine seeking at baseline and relapse was investigated using in situ hybridization of the cellular activity marker C-fos and assessment of the sensitivity of instrumental drug seeking to dopamine receptor blockade in the dorsomedial striatum-dependent goal-directed and DLS-dependent habit systems.The development of a DLS-dependent cue-controlled cocaine-seeking habit prior to abstinence resulted in a marked increase in drug seeking at relapse, which was not motivated by a cocaine withdrawal state and was no longer dependent on the DLS habit system. Instead, it reflected the emergence of negative urgency caused by the prevention of the performance of the habit during abstinence and underpinned by transient engagement of the goal-directed system.These results show that ingrained cue-controlled drug-seeking habits increase the pressure to relapse." @default.
- W3206795340 created "2021-10-25" @default.
- W3206795340 creator A5025569771 @default.
- W3206795340 creator A5029232394 @default.
- W3206795340 creator A5033466050 @default.
- W3206795340 creator A5038837003 @default.
- W3206795340 creator A5044645453 @default.
- W3206795340 creator A5063194083 @default.
- W3206795340 creator A5066282182 @default.
- W3206795340 date "2022-06-01" @default.
- W3206795340 modified "2023-10-06" @default.
- W3206795340 title "Negative Urgency Exacerbates Relapse to Cocaine Seeking After Abstinence" @default.
- W3206795340 cites W1768471585 @default.
- W3206795340 cites W1820027879 @default.
- W3206795340 cites W1851654707 @default.
- W3206795340 cites W1877246726 @default.
- W3206795340 cites W1883241039 @default.
- W3206795340 cites W1919945492 @default.
- W3206795340 cites W1971014321 @default.
- W3206795340 cites W1976053237 @default.
- W3206795340 cites W1976236173 @default.
- W3206795340 cites W1982873646 @default.
- W3206795340 cites W1984101306 @default.
- W3206795340 cites W1986079135 @default.
- W3206795340 cites W1987298352 @default.
- W3206795340 cites W1987369456 @default.
- W3206795340 cites W1989416066 @default.
- W3206795340 cites W1991882455 @default.
- W3206795340 cites W1996581174 @default.
- W3206795340 cites W1999948756 @default.
- W3206795340 cites W2006746363 @default.
- W3206795340 cites W2012129826 @default.
- W3206795340 cites W2012922094 @default.
- W3206795340 cites W2013262725 @default.
- W3206795340 cites W2014459415 @default.
- W3206795340 cites W2015559939 @default.
- W3206795340 cites W2017934537 @default.
- W3206795340 cites W2020107325 @default.
- W3206795340 cites W2021564547 @default.
- W3206795340 cites W2035064159 @default.
- W3206795340 cites W2035240167 @default.
- W3206795340 cites W2035413054 @default.
- W3206795340 cites W2039464894 @default.
- W3206795340 cites W2043765696 @default.
- W3206795340 cites W2046567817 @default.
- W3206795340 cites W2048594339 @default.
- W3206795340 cites W2048606266 @default.
- W3206795340 cites W2053170041 @default.
- W3206795340 cites W2054749214 @default.
- W3206795340 cites W2069640850 @default.
- W3206795340 cites W2077150252 @default.
- W3206795340 cites W2077460838 @default.
- W3206795340 cites W2080055692 @default.
- W3206795340 cites W2083537735 @default.
- W3206795340 cites W2086265757 @default.
- W3206795340 cites W2087657646 @default.
- W3206795340 cites W2089277503 @default.
- W3206795340 cites W2092483236 @default.
- W3206795340 cites W2092533548 @default.
- W3206795340 cites W2099527614 @default.
- W3206795340 cites W2105109101 @default.
- W3206795340 cites W2106862702 @default.
- W3206795340 cites W2112337921 @default.
- W3206795340 cites W2129530731 @default.
- W3206795340 cites W2129688965 @default.
- W3206795340 cites W2131557002 @default.
- W3206795340 cites W2132439203 @default.
- W3206795340 cites W2135505898 @default.
- W3206795340 cites W2148137149 @default.
- W3206795340 cites W2165398609 @default.
- W3206795340 cites W2168838912 @default.
- W3206795340 cites W2171592578 @default.
- W3206795340 cites W2258184930 @default.
- W3206795340 cites W2335426010 @default.
- W3206795340 cites W2500761496 @default.
- W3206795340 cites W2565979495 @default.
- W3206795340 cites W2607829808 @default.
- W3206795340 cites W2765820768 @default.
- W3206795340 cites W2769019845 @default.
- W3206795340 cites W2790238719 @default.
- W3206795340 cites W2806175929 @default.
- W3206795340 cites W2914832532 @default.
- W3206795340 cites W2939279096 @default.
- W3206795340 cites W2945136576 @default.
- W3206795340 cites W2949184225 @default.
- W3206795340 cites W2951706111 @default.
- W3206795340 cites W2954869351 @default.
- W3206795340 cites W2976496960 @default.
- W3206795340 cites W2989623476 @default.
- W3206795340 cites W2999232346 @default.
- W3206795340 cites W3047519961 @default.
- W3206795340 cites W3102361237 @default.
- W3206795340 cites W3112790012 @default.
- W3206795340 cites W3146605924 @default.
- W3206795340 cites W4250869126 @default.
- W3206795340 cites W4253405426 @default.
- W3206795340 doi "https://doi.org/10.1016/j.biopsych.2021.10.009" @default.
- W3206795340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34922736" @default.