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• W3206806738 endingPage "1008" @default.
• W3206806738 startingPage "994" @default.
• W3206806738 abstract "How T lymphocytes tune their responses to different strengths of stimulation is a fundamental question in immunology. Recent work using new optogenetic, single-cell genomic, and live-imaging approaches has revealed that stimulation strength controls the rate of individual cell responses within a population. Moreover, these responses have been found to use shared molecular programs, regardless of stimulation strength. However, additional data indicate that stimulation duration or cytokine feedback can impact later gene expression phenotypes of activated cells. In-depth molecular studies have suggested mechanisms by which stimulation strength might modulate the probability of T cell activation. This emerging model allows activating T cells to achieve a wide range of population responses through probabilistic control within individual cells." @default.
• W3206806738 created "2021-10-25" @default.
• W3206806738 creator A5010077848 @default.
• W3206806738 creator A5024345109 @default.
• W3206806738 creator A5049554151 @default.
• W3206806738 creator A5077263817 @default.
• W3206806738 date "2021-11-01" @default.
• W3206806738 modified "2023-10-13" @default.
• W3206806738 title "Staggered starts in the race to T cell activation" @default.
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