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• W3206827069 startingPage "117741" @default.
• W3206827069 abstract "Motor neuron diseases (MNDs), including amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and spinal and bulbar muscular atrophy (SBMA), are a heterogeneous group of neurodegenerative disorders characterized by motor neuron loss. Despite variability in onset, progression and genetic causes, these disorders share a common involvement of skeletal muscle that is suspected to have a relevant role in MND pathogenesis. Due to the key role of muscle-specific microRNAs (myomiRs) in muscle development, here we investigated the expression of miR-206, miR-133a, miR-133b and miR-1 myomiRs, and their target genes, in G93A-SOD1 ALS, Δ7SMA and KI-SBMA mouse muscle during disease progression." @default.
• W3206827069 created "2021-10-25" @default.
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• W3206827069 date "2021-10-01" @default.
• W3206827069 modified "2023-09-26" @default.
• W3206827069 title "Dysregulation of myomiRs as common pathogenic feature associated with muscle atrophy in ALS, SMA and SBMA: Evidence from animal models and human patients" @default.
• W3206827069 doi "https://doi.org/10.1016/j.jns.2021.117741" @default.
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