Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206836705> ?p ?o ?g. }
- W3206836705 abstract "Mitochondrial nucleoside diphosphate kinase (NDPK-D, NME4, NM23-H4) is a multifunctional enzyme mainly localized in the intermembrane space, bound to the inner membrane.We constructed loss-of-function mutants of NDPK-D, lacking either NDP kinase activity or membrane interaction and expressed mutants or wild-type protein in cancer cells. In a complementary approach, we performed depletion of NDPK-D by RNA interference. Both loss-of-function mutations and NDPK-D depletion promoted epithelial-mesenchymal transition and increased migratory and invasive potential. Immunocompromised mice developed more metastases when injected with cells expressing mutant NDPK-D as compared to wild-type. This metastatic reprogramming is a consequence of mitochondrial alterations, including fragmentation and loss of mitochondria, a metabolic switch from respiration to glycolysis, increased ROS generation, and further metabolic changes in mitochondria, all of which can trigger pro-metastatic protein expression and signaling cascades. In human cancer, NME4 expression is negatively associated with markers of epithelial-mesenchymal transition and tumor aggressiveness and a good prognosis factor for beneficial clinical outcome.These data demonstrate NME4 as a novel metastasis suppressor gene, the first localizing to mitochondria, pointing to a role of mitochondria in metastatic dissemination." @default.
- W3206836705 created "2021-10-25" @default.
- W3206836705 creator A5000812562 @default.
- W3206836705 creator A5002057344 @default.
- W3206836705 creator A5004357356 @default.
- W3206836705 creator A5017113646 @default.
- W3206836705 creator A5018486922 @default.
- W3206836705 creator A5019326499 @default.
- W3206836705 creator A5032240231 @default.
- W3206836705 creator A5033571451 @default.
- W3206836705 creator A5034687681 @default.
- W3206836705 creator A5035391817 @default.
- W3206836705 creator A5035770418 @default.
- W3206836705 creator A5037964830 @default.
- W3206836705 creator A5040004643 @default.
- W3206836705 creator A5041831885 @default.
- W3206836705 creator A5043797392 @default.
- W3206836705 creator A5047858570 @default.
- W3206836705 creator A5058978995 @default.
- W3206836705 creator A5061909637 @default.
- W3206836705 creator A5062411769 @default.
- W3206836705 creator A5062899122 @default.
- W3206836705 creator A5063337999 @default.
- W3206836705 creator A5064913261 @default.
- W3206836705 creator A5069325064 @default.
- W3206836705 creator A5074609427 @default.
- W3206836705 creator A5075219542 @default.
- W3206836705 creator A5075515144 @default.
- W3206836705 creator A5075758610 @default.
- W3206836705 creator A5090178944 @default.
- W3206836705 creator A5014967891 @default.
- W3206836705 date "2021-10-21" @default.
- W3206836705 modified "2023-10-18" @default.
- W3206836705 title "The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor" @default.
- W3206836705 cites W146607653 @default.
- W3206836705 cites W1856161887 @default.
- W3206836705 cites W1964081206 @default.
- W3206836705 cites W1966473541 @default.
- W3206836705 cites W1970395441 @default.
- W3206836705 cites W1970668029 @default.
- W3206836705 cites W1973941736 @default.
- W3206836705 cites W1979927283 @default.
- W3206836705 cites W1984389940 @default.
- W3206836705 cites W1988529613 @default.
- W3206836705 cites W1989409972 @default.
- W3206836705 cites W1995364852 @default.
- W3206836705 cites W2002445309 @default.
- W3206836705 cites W2005895632 @default.
- W3206836705 cites W2007599495 @default.
- W3206836705 cites W2007917102 @default.
- W3206836705 cites W2010243889 @default.
- W3206836705 cites W2022479474 @default.
- W3206836705 cites W2023234570 @default.
- W3206836705 cites W2025215949 @default.
- W3206836705 cites W2026397465 @default.
- W3206836705 cites W2029478652 @default.
- W3206836705 cites W2030224950 @default.
- W3206836705 cites W2032712305 @default.
- W3206836705 cites W2034105438 @default.
- W3206836705 cites W2042898512 @default.
- W3206836705 cites W2043469192 @default.
- W3206836705 cites W2048703875 @default.
- W3206836705 cites W2056351479 @default.
- W3206836705 cites W2070143299 @default.
- W3206836705 cites W2071359561 @default.
- W3206836705 cites W2074330066 @default.
- W3206836705 cites W2076374687 @default.
- W3206836705 cites W2083068177 @default.
- W3206836705 cites W2083129364 @default.
- W3206836705 cites W2088511656 @default.
- W3206836705 cites W2111372916 @default.
- W3206836705 cites W2114843025 @default.
- W3206836705 cites W2115470184 @default.
- W3206836705 cites W2122333207 @default.
- W3206836705 cites W2123808188 @default.
- W3206836705 cites W2128715680 @default.
- W3206836705 cites W2130934290 @default.
- W3206836705 cites W2136196115 @default.
- W3206836705 cites W2136269288 @default.
- W3206836705 cites W2137579180 @default.
- W3206836705 cites W2142681992 @default.
- W3206836705 cites W2142700343 @default.
- W3206836705 cites W2143543279 @default.
- W3206836705 cites W2144480059 @default.
- W3206836705 cites W2144893198 @default.
- W3206836705 cites W2149441684 @default.
- W3206836705 cites W2149796346 @default.
- W3206836705 cites W2153850374 @default.
- W3206836705 cites W2155890719 @default.
- W3206836705 cites W2165200432 @default.
- W3206836705 cites W2165292984 @default.
- W3206836705 cites W2167540008 @default.
- W3206836705 cites W2167956058 @default.
- W3206836705 cites W2168034652 @default.
- W3206836705 cites W2173565120 @default.
- W3206836705 cites W2179132463 @default.
- W3206836705 cites W2196060782 @default.
- W3206836705 cites W2240173075 @default.
- W3206836705 cites W2255753899 @default.
- W3206836705 cites W2261443398 @default.