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- W3206864377 abstract "Background: Metabolic Syndrome (MS) prevalence is increasing in Indonesia's rural area. The key pathogenetic mechanism of MS is insulin resistance which can be diagnosed by Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). There is no predefined cut-off for this index in Indonesian rural population. Methods: As many as 1,300 adults aged 18-60 years from Sugarspin study in Nangapanda, Flores, Indonesia were divided into different groups based on sex. We determined the cut-off points of HOMA-IR in each group by calculation of the 75th (p75) and 90th percentiles (p90) in healthy subjects and by receiver operating characteristics (ROC) analysis of MS and non-MS subjects. Results: Using both methods, HOMA-IR cut-offs were different between men and women. The HOMA-IR cut-offs for healthy men were 0·9 (p75) and 1·242 (p90); for healthy women were 1·208 (p75) and 1·656 (p90). By ROC, the HOMA-IR cut-off for men was 1·185 and for women was 1·505. Conclusion: HOMA-IR cut-offs calculated by percentiles and ROC analysis differed according to sex and ethnicity. The cut-offs for men were 0·9 (p75), 1·242 (p90), and 1·185 (ROC); for women were 1·208 (p75), 1·656 (p90), and 1·505 (ROC).Funding Statement: The Sugarspin study was funded by the SPIN Royal Netherlands Academy of Arts and Science (KNAW), Ref 57-SPIN3-JRP and Universitas Indonesia (Research Grant BOPTN 2742/ H2.R12/HKP.05.00/2013.) This study was funded by Universitas Indonesia with grant number NKB-2766/UN2.RST/HKP/.05.00/2020.Declaration of Interests: This study have no competing interests.Ethics Approval Statement: This study has been approved by The Health Research Ethical Committee, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia." @default.
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- W3206864377 date "2021-01-01" @default.
- W3206864377 modified "2023-09-24" @default.
- W3206864377 title "The Cut-Off Values of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in Indonesian Rural Population" @default.
- W3206864377 doi "https://doi.org/10.2139/ssrn.3777179" @default.
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