FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206867691> ?p ?o ?g. }

• W3206867691 abstract "The roundworm Ascaris suum is one of the parasites with the greatest economic impact on pig farming. In this context, lower weight gain is hypothesized to be due to decreased nutrient absorption. This study aims at characterizing the effects of A. suum infection on intestinal nutrient transport processes and potential molecular mechanisms.Three groups of six piglets each were infected orally (10,000 embryonated A. suum eggs) in a single dose (single infection). Another three groups were infected orally (1000 embryonated eggs) for 10 consecutive days (trickle infection). Animals were necropsied 21, 35 and 49 days post-infection (dpi). Three groups served as respective controls. The Ussing chamber technique was applied for the functional characterization of small intestinal tissues [short-circuit currents (Isc) as induced by glucose, alanine and peptides; 3H-glucose net flux rates; tissue conductance (Gt)]. Transcription and expression levels of relevant cytokines and nutrient transporters were evaluated (qPCR/western blot).Peptide- and alanine-induced changes in Isc were significantly decreased in the jejunum and ileum of the trickle-infected group at 49 dpi and in the ileum of the single-infected group at 49 dpi. No significant differences regarding glucose transport were observed between the Ascaris-infected groups and the control group in Ussing chamber experiments. Transcription levels of the glucose and peptide transporters as well as of selected transcription factors (transcription of signal transducer and activator of transcription 6 [STAT6] and hypoxia-inducible factor 1-alpha [Hif-1α]) were significantly increased in response to both infection types after some periods. The transcription of interleukins 4 and 13 varied between decrease and increase regarding the respective time points, as did the protein expression of glucose transporters. The expression of the peptide transporter PepT1 was significantly decreased in the ileal single-infected group at 35 dpi. Hif-1α was significantly increased in the ileal tissue from the single-infected group at 21 dpi and in the trickle-infected group at 35 dpi. The expression levels of Na+/K+-ATPase and ASCT1 remained unaffected.In contrast to the current hypothesis, these results indicate that the nutrient deprivation induced by A. suum cannot be explained by transcriptional or expression changes alone and requires further studies." @default.
• W3206867691 created "2021-10-25" @default.
• W3206867691 creator A5002514626 @default.
• W3206867691 creator A5037499008 @default.
• W3206867691 creator A5061360576 @default.
• W3206867691 creator A5070114559 @default.
• W3206867691 creator A5072157732 @default.
• W3206867691 creator A5079506557 @default.
• W3206867691 date "2021-10-14" @default.
• W3206867691 modified "2023-09-27" @default.
• W3206867691 title "Changes in porcine nutrient transport physiology in response to Ascaris suum infection" @default.
• W3206867691 cites W1828221682 @default.
• W3206867691 cites W1956777900 @default.
• W3206867691 cites W1969342975 @default.
• W3206867691 cites W1977429862 @default.
• W3206867691 cites W1981295957 @default.
• W3206867691 cites W1981409699 @default.
• W3206867691 cites W1984684344 @default.
• W3206867691 cites W1996462589 @default.
• W3206867691 cites W1998281149 @default.
• W3206867691 cites W2003368252 @default.
• W3206867691 cites W2016496152 @default.
• W3206867691 cites W2019870550 @default.
• W3206867691 cites W2020413208 @default.
• W3206867691 cites W2027095346 @default.
• W3206867691 cites W2035456909 @default.
• W3206867691 cites W2037299298 @default.
• W3206867691 cites W2041352234 @default.
• W3206867691 cites W2043871531 @default.
• W3206867691 cites W2065109640 @default.
• W3206867691 cites W2071934657 @default.
• W3206867691 cites W2082038268 @default.
• W3206867691 cites W2083748040 @default.
• W3206867691 cites W2086150776 @default.
• W3206867691 cites W2093821272 @default.
• W3206867691 cites W2110015632 @default.
• W3206867691 cites W2112924167 @default.
• W3206867691 cites W2137431663 @default.
• W3206867691 cites W2148428564 @default.
• W3206867691 cites W2157757382 @default.
• W3206867691 cites W2165658685 @default.
• W3206867691 cites W2165947738 @default.
• W3206867691 cites W2332815487 @default.
• W3206867691 cites W2396364912 @default.
• W3206867691 cites W2413439113 @default.
• W3206867691 cites W2467911517 @default.
• W3206867691 cites W2787876956 @default.
• W3206867691 cites W2794069333 @default.
• W3206867691 cites W2798089057 @default.
• W3206867691 cites W2883683829 @default.
• W3206867691 cites W2923976867 @default.
• W3206867691 cites W4234288885 @default.
• W3206867691 doi "https://doi.org/10.1186/s13071-021-05029-1" @default.
• W3206867691 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8515719" @default.
• W3206867691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34649607" @default.
• W3206867691 hasPublicationYear "2021" @default.
• W3206867691 type Work @default.
• W3206867691 sameAs 3206867691 @default.
• W3206867691 citedByCount "3" @default.
• W3206867691 countsByYear W32068676912022 @default.
• W3206867691 crossrefType "journal-article" @default.
• W3206867691 hasAuthorship W3206867691A5002514626 @default.
• W3206867691 hasAuthorship W3206867691A5037499008 @default.
• W3206867691 hasAuthorship W3206867691A5061360576 @default.
• W3206867691 hasAuthorship W3206867691A5070114559 @default.
• W3206867691 hasAuthorship W3206867691A5072157732 @default.
• W3206867691 hasAuthorship W3206867691A5079506557 @default.
• W3206867691 hasBestOaLocation W32068676911 @default.
• W3206867691 hasConcept C126322002 @default.
• W3206867691 hasConcept C129470801 @default.
• W3206867691 hasConcept C134018914 @default.
• W3206867691 hasConcept C165901193 @default.
• W3206867691 hasConcept C203014093 @default.
• W3206867691 hasConcept C2522874641 @default.
• W3206867691 hasConcept C2777226302 @default.
• W3206867691 hasConcept C2779845534 @default.
• W3206867691 hasConcept C2779932011 @default.
• W3206867691 hasConcept C49039625 @default.
• W3206867691 hasConcept C71924100 @default.
• W3206867691 hasConcept C86803240 @default.
• W3206867691 hasConceptScore W3206867691C126322002 @default.
• W3206867691 hasConceptScore W3206867691C129470801 @default.
• W3206867691 hasConceptScore W3206867691C134018914 @default.
• W3206867691 hasConceptScore W3206867691C165901193 @default.
• W3206867691 hasConceptScore W3206867691C203014093 @default.
• W3206867691 hasConceptScore W3206867691C2522874641 @default.
• W3206867691 hasConceptScore W3206867691C2777226302 @default.
• W3206867691 hasConceptScore W3206867691C2779845534 @default.
• W3206867691 hasConceptScore W3206867691C2779932011 @default.
• W3206867691 hasConceptScore W3206867691C49039625 @default.
• W3206867691 hasConceptScore W3206867691C71924100 @default.
• W3206867691 hasConceptScore W3206867691C86803240 @default.
• W3206867691 hasFunder F4320320879 @default.
• W3206867691 hasIssue "1" @default.
• W3206867691 hasLocation W32068676911 @default.
• W3206867691 hasLocation W32068676912 @default.
• W3206867691 hasLocation W32068676913 @default.
• W3206867691 hasOpenAccess W3206867691 @default.
• W3206867691 hasPrimaryLocation W32068676911 @default.
• W3206867691 hasRelatedWork W1580858332 @default.

• next