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- W3206869904 abstract "Human Vδ2 cells are innate-like γδ T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of Vδ2 T cells licensed with an intrinsic hyper-responsiveness against cancer. Indeed, the transcriptomic profiles of NKG2A+ and NKG2A- cells characterize two distinct intralineages of Vδ2 T lymphocytes that appear early during development, keep their phenotypes, and show self-renewal capabilities in adult life. The hyper-responsiveness of NKG2A+ Vδ2 T cells is counterbalanced by the inhibitory signaling delivered by human leukocyte antigen E (HLA-E) expressed on malignant cells as a tumor-escape mechanism. However, either masking or knocking out NKG2A restores the capacity of Vδ2 T cells to exert the highest effector functions even against HLA-E+ tumors. This is highly relevant in the clinic, as the different degrees of engagement of the NKG2A-HLA-E checkpoint in hepatocellular carcinoma, glioblastoma, and non-small cell lung cancer directly impact patients' overall survival. These findings open avenues for developing combined cellular and immunologic anticancer therapies." @default.
- W3206869904 created "2021-10-25" @default.
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- W3206869904 date "2021-10-01" @default.
- W3206869904 modified "2023-10-18" @default.
- W3206869904 title "NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions" @default.
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- W3206869904 doi "https://doi.org/10.1016/j.celrep.2021.109871" @default.
- W3206869904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34686325" @default.
- W3206869904 hasPublicationYear "2021" @default.