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- W3206888311 abstract "To date, it is known that haloperidol is used to treat productive psychopathological symptoms in acute alcoholic hallucinosis, but its use is associated with a high risk of developing undesirable drug reactions (NLR). A number of isoenzymes of the cytochrome P-450 family take part in the metabolism of haloperidol. The biotransformation of haloperidol occurs with the participation of the CYP2D6 isoenzyme encoded by the gene of the same name. The CYP2D6 gene is highly polymorphic, and this polymorphism can lead to a change in the activity of the encoded isoenzyme. Changes in the rate of biotransformation of haloperidol may affect the profile of its effectiveness and safety. This review is aimed at analyzing the information accumulated in the literature on the role of genetic factors in the formation of an individual response to haloperidol therapy in patients with acute alcoholic hallucinosis." @default.
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- W3206888311 date "2021-07-11" @default.
- W3206888311 modified "2023-10-01" @default.
- W3206888311 title "Personalized approach to the administration of haloperidol in patients with acute alcoholic hallucinatie (literature review)" @default.
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- W3206888311 doi "https://doi.org/10.33920/med-01-2108-05" @default.
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