FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206906099> ?p ?o ?g. }

• W3206906099 endingPage "494" @default.
• W3206906099 startingPage "486" @default.
• W3206906099 abstract "Allogeneic transplant (alloHCT) and chimeric antigen receptor modified (CAR)-T cell therapy are potentially cuarative options of diffuse large B-cell lymphoma (DLBCL) relapsing after an autologous (auto)HCT. Although the Center for International Blood and Marrow Transplant Research (CIBMTR) prognostic model can predict outcomes of alloHCT in DLBCL after autoHCT failure, corresponding models of CAR-T treatment in similar patient populations are not available. In this noncomparative registry analysis, we report outcomes of patients with DLBCL (≥18 years) undergoing a reduced intensity alloHCT or CAR-T therapy with axicabtagene ciloleucel during 2012 to 2019 after a prior auto-HCT failure and apply the CIBMTR prognostic model to CAR-T recipients. A total of 584 patients were included. The 1-year relapse, nonrelapse mortality, overall survival (OS), and progression-free survival for CAR-T treatment after autoHCT failure were 39.5%, 4.8%, 73.4%, and 55.7%, respectively. The corresponding rates in the alloHCT cohort were 26.2%, 20.0%, 65.6%, and 53.8%, respectively. The 1-year OS of alloHCT recipients classified as low-, intermediate- and high/very high-risk groups according to the CIBMTR prognostic score was 73.3%, 59.9%, and 46.3%, respectively (P = .002). The corresponding rates for low-, intermediate-, and high/very high-risk CAR-T patients were 88.4%, 76.4%, and 52.8%, respectively (P < .001). This registry analysis shows that both CAR-T and alloHCT can provide durable remissions in a subset of patients with DLBCL relapsing after a prior autoHCT. The simple CIBMTR prognostic score can be used to identify patients at high risk of treatment failure after either procedure. Evaluation of novel relapse mitigations strategies after cellular immunotherapies are warranted in these high-risk patients." @default.
• W3206906099 created "2021-10-25" @default.
• W3206906099 creator A5004025497 @default.
• W3206906099 creator A5004973468 @default.
• W3206906099 creator A5009719497 @default.
• W3206906099 creator A5010158325 @default.
• W3206906099 creator A5011030256 @default.
• W3206906099 creator A5015521146 @default.
• W3206906099 creator A5016527172 @default.
• W3206906099 creator A5021394406 @default.
• W3206906099 creator A5039574726 @default.
• W3206906099 creator A5040185213 @default.
• W3206906099 creator A5048472481 @default.
• W3206906099 creator A5051793137 @default.
• W3206906099 creator A5054491167 @default.
• W3206906099 creator A5058005688 @default.
• W3206906099 creator A5075085884 @default.
• W3206906099 creator A5077959781 @default.
• W3206906099 creator A5078036181 @default.
• W3206906099 creator A5078600949 @default.
• W3206906099 creator A5080912052 @default.
• W3206906099 creator A5086490383 @default.
• W3206906099 creator A5086815330 @default.
• W3206906099 creator A5091083304 @default.
• W3206906099 date "2022-01-18" @default.
• W3206906099 modified "2023-09-30" @default.
• W3206906099 title "Allogeneic transplant and CAR-T therapy after autologous transplant failure in DLBCL: a noncomparative cohort analysis" @default.
• W3206906099 cites W1491993932 @default.
• W3206906099 cites W1530764705 @default.
• W3206906099 cites W1997353354 @default.
• W3206906099 cites W2034892179 @default.
• W3206906099 cites W2066175494 @default.
• W3206906099 cites W2078782557 @default.
• W3206906099 cites W2085459287 @default.
• W3206906099 cites W2090377851 @default.
• W3206906099 cites W2097426308 @default.
• W3206906099 cites W2119147717 @default.
• W3206906099 cites W2133201432 @default.
• W3206906099 cites W2150587745 @default.
• W3206906099 cites W2152197116 @default.
• W3206906099 cites W2165885469 @default.
• W3206906099 cites W2300560420 @default.
• W3206906099 cites W2598700764 @default.
• W3206906099 cites W2769990542 @default.
• W3206906099 cites W2773804840 @default.
• W3206906099 cites W2775369717 @default.
• W3206906099 cites W2903225254 @default.
• W3206906099 cites W2905654445 @default.
• W3206906099 cites W2914763076 @default.
• W3206906099 cites W2948517706 @default.
• W3206906099 cites W2981626013 @default.
• W3206906099 cites W2984927918 @default.
• W3206906099 cites W2997775719 @default.
• W3206906099 cites W3024978145 @default.
• W3206906099 cites W3030925457 @default.
• W3206906099 cites W3034162969 @default.
• W3206906099 cites W3037697670 @default.
• W3206906099 cites W3043369050 @default.
• W3206906099 cites W3044532926 @default.
• W3206906099 cites W3082855561 @default.
• W3206906099 cites W3087756659 @default.
• W3206906099 cites W3092023747 @default.
• W3206906099 cites W3095173757 @default.
• W3206906099 cites W3101826014 @default.
• W3206906099 cites W3112524531 @default.
• W3206906099 cites W3119227305 @default.
• W3206906099 cites W3134205746 @default.
• W3206906099 cites W3161133732 @default.
• W3206906099 cites W4206076275 @default.
• W3206906099 doi "https://doi.org/10.1182/bloodadvances.2021005788" @default.
• W3206906099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34673903" @default.
• W3206906099 hasPublicationYear "2022" @default.
• W3206906099 type Work @default.
• W3206906099 sameAs 3206906099 @default.
• W3206906099 citedByCount "20" @default.
• W3206906099 countsByYear W32069060992022 @default.
• W3206906099 countsByYear W32069060992023 @default.
• W3206906099 crossrefType "journal-article" @default.
• W3206906099 hasAuthorship W3206906099A5004025497 @default.
• W3206906099 hasAuthorship W3206906099A5004973468 @default.
• W3206906099 hasAuthorship W3206906099A5009719497 @default.
• W3206906099 hasAuthorship W3206906099A5010158325 @default.
• W3206906099 hasAuthorship W3206906099A5011030256 @default.
• W3206906099 hasAuthorship W3206906099A5015521146 @default.
• W3206906099 hasAuthorship W3206906099A5016527172 @default.
• W3206906099 hasAuthorship W3206906099A5021394406 @default.
• W3206906099 hasAuthorship W3206906099A5039574726 @default.
• W3206906099 hasAuthorship W3206906099A5040185213 @default.
• W3206906099 hasAuthorship W3206906099A5048472481 @default.
• W3206906099 hasAuthorship W3206906099A5051793137 @default.
• W3206906099 hasAuthorship W3206906099A5054491167 @default.
• W3206906099 hasAuthorship W3206906099A5058005688 @default.
• W3206906099 hasAuthorship W3206906099A5075085884 @default.
• W3206906099 hasAuthorship W3206906099A5077959781 @default.
• W3206906099 hasAuthorship W3206906099A5078036181 @default.
• W3206906099 hasAuthorship W3206906099A5078600949 @default.
• W3206906099 hasAuthorship W3206906099A5080912052 @default.
• W3206906099 hasAuthorship W3206906099A5086490383 @default.

• next