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- W3206932128 abstract "Human infection with SARS-CoV-2, the agent of COVID-19, affects both the central nervous system (CNS) and the peripheral nervous system (PNS) including the muscle (Román GC, SpencerPS, Reis J, et al. The Neurology of COVID-19 Revisited. J Neurol Sci 414 (2020) 116884). This virus is neurogenic and invades the CNS via cranial nerve I, progressing into rhinencephalon and brainstem respiratory centers resulting in irreversible respiratory failure responsible for most of the 6.9 million excess deaths due to this coronavirus (Institute for Health Metrics and Evaluation, University of Washington [www.healthdata.org]). Early CNS manifestations include headache and decreased responsiveness, anosmia and ageusia. Viral attachment to ACE2 receptors in endothelium cause widespread endotheliitis, coagulopathy, small-vessel disease, arterial and venous thromboses responsible for large-vessel ischemic strokes, cerebral venous thrombosis, intracerebral hemorrhage and subarachnoid hemorrhage along with a thrombotic state. Acute hemorrhagic necrotizing encephalopathy is associated to the cytokine storm. There are isolated reports of seizures, encephalopathy, meningitis, and encephalitis. Acute transverse myelitis is more frequent than expected and has also been reported as a complication of the Oxford AstraZeneca vaccine (Román GC, Gracia F, Torres A, et al. SARS-CoV-2-associated acute transverse myelitis: Clinical review of 43 cases and 3 post-vaccination reports. Front Immunol 26 April 2021). Guillain-Barré syndrome is the most common neurological disorder affecting the PNS but Miller Fisher syndrome and polyneuritis cranialis may also occur. There are rare instances of viral myopathy with rhabdomyolysis. International neuroepidemiological collaboration has helped to define the natural history of the COVID-19 neurology during this pandemic." @default.
- W3206932128 created "2021-10-25" @default.
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- W3206932128 date "2021-10-01" @default.
- W3206932128 modified "2023-10-17" @default.
- W3206932128 title "The neurologic complications of COVID-19" @default.
- W3206932128 doi "https://doi.org/10.1016/j.jns.2021.117876" @default.
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