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• W3206973630 endingPage "11121" @default.
• W3206973630 startingPage "11121" @default.
• W3206973630 abstract "The aim of this study was to compare the bone regeneration ability of particle and block bones, acting as bone scaffolds, with recombinant human bone morphogenetic protein (rhBMP)-2 and evaluate them as rhBMP-2 carriers. Demineralized bovine bone particles, blocks, and rhBMP-2 were grafted into the subperiosteal space of a rat calvarial bone, and the rats were randomly divided into four groups: particle, block, P (particle)+BMP, and B (block)+BMP groups. The bone volume of the B+BMP group was significantly higher than that of the other groups (p < 0.00), with no significant difference in bone mineral density. The average adipose tissue volume of the B+BMP group was higher than that of the P+BMP group, although the difference was not significant. Adipose tissue formation was observed in the rhBMP-2 application group. Histologically, the particle and B+BMP groups showed higher formation of a new bone. However, adipose tissue and void spaces were also formed, especially in the B+BMP group. Hence, despite the formation of a large central void space, rhBMP-2 could be effectively used with block bone scaffolds and showed excellent new bone formation. Further studies are required to evaluate the changes in adipose tissue." @default.
• W3206973630 created "2021-10-25" @default.
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• W3206973630 date "2021-10-15" @default.
• W3206973630 modified "2023-09-26" @default.
• W3206973630 title "Comparison of Bone Regeneration in Different Forms of Bovine Bone Scaffolds with Recombinant Human Bone Morphogenetic Protein-2" @default.
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• W3206973630 doi "https://doi.org/10.3390/ijms222011121" @default.
• W3206973630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8537640" @default.
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• W3206973630 hasPublicationYear "2021" @default.
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