Matches in SemOpenAlex for { <https://semopenalex.org/work/W3206977881> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3206977881 endingPage "1631" @default.
- W3206977881 startingPage "1623" @default.
- W3206977881 abstract "Aryl hydrocarbon receptors (AHRs), a class of ligand-dependent nuclear receptors that regulate cellular responses by inducing the expression of various target genes in response to external signals, are implicated in maintaining retinal tissue homeostasis. Previous studies have shown that the regulation of AHR-induced gene expression requires transcriptional co-regulators. However, it is not yet clear how chromatin remodelers, histone methyltransferases and coactivators interact during AHR-mediated gene expression in human retinal cells. In this study, we reveal that the histone methyltransferase MLL1 and the coactivator FLII are involved in AHR-mediated gene expression in retinal pigment epithelial cells. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) significantly increased the expression of CYP1A1, CYP1B1 and AHRR in ARPE-19 cells, whereas FLII or MLL1 depletion significantly reduced the expression of these genes induced by TCDD. Mechanistically, FLII binds to AHR in a ligand-dependent manner in ARPE-19 cells. In particular, the binding of FLII to MLL1 occurs through the GelB domain of FLII. In addition, MLL1 binds to AHR in a ligand-independent manner. FLII is involved in the recruitment of the BRG1 chromatin remodeler and MLL1 histone methyltransferase to the AHR-regulated CYP1A1 gene region in ARPE-19 cells and consequently, plays an important role in RNA polymerase II binding and transcriptional activity by modulating chromatin accessibility. Our results identify the functions and mechanisms of action of FLII and MLL1 in AHR-induced gene expression in human retinal pigment epithelial cells." @default.
- W3206977881 created "2021-10-25" @default.
- W3206977881 creator A5090472416 @default.
- W3206977881 date "2021-10-16" @default.
- W3206977881 modified "2023-09-25" @default.
- W3206977881 title "FLII and MLL1 Cooperatively Regulate Aryl Hydrocarbon Receptor-Mediated Transcription in ARPE-19 Cells" @default.
- W3206977881 cites W185914786 @default.
- W3206977881 cites W1989747234 @default.
- W3206977881 cites W1994025305 @default.
- W3206977881 cites W2000423718 @default.
- W3206977881 cites W2001720244 @default.
- W3206977881 cites W2040764095 @default.
- W3206977881 cites W2050179922 @default.
- W3206977881 cites W2069765448 @default.
- W3206977881 cites W2077366389 @default.
- W3206977881 cites W2083954183 @default.
- W3206977881 cites W2085420405 @default.
- W3206977881 cites W2093460761 @default.
- W3206977881 cites W2095439482 @default.
- W3206977881 cites W2136501493 @default.
- W3206977881 cites W2153237860 @default.
- W3206977881 cites W2302176581 @default.
- W3206977881 cites W2460592200 @default.
- W3206977881 cites W2602144651 @default.
- W3206977881 cites W2603472668 @default.
- W3206977881 cites W2801810482 @default.
- W3206977881 cites W2989892628 @default.
- W3206977881 cites W3009348657 @default.
- W3206977881 cites W3037571551 @default.
- W3206977881 cites W3080351630 @default.
- W3206977881 cites W3152607042 @default.
- W3206977881 cites W3176337654 @default.
- W3206977881 cites W4245127532 @default.
- W3206977881 cites W1984552848 @default.
- W3206977881 doi "https://doi.org/10.3390/cimb43030115" @default.
- W3206977881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34698116" @default.
- W3206977881 hasPublicationYear "2021" @default.
- W3206977881 type Work @default.
- W3206977881 sameAs 3206977881 @default.
- W3206977881 citedByCount "0" @default.
- W3206977881 crossrefType "journal-article" @default.
- W3206977881 hasAuthorship W3206977881A5090472416 @default.
- W3206977881 hasBestOaLocation W32069778811 @default.
- W3206977881 hasConcept C104317684 @default.
- W3206977881 hasConcept C150194340 @default.
- W3206977881 hasConcept C150425827 @default.
- W3206977881 hasConcept C165864922 @default.
- W3206977881 hasConcept C27153228 @default.
- W3206977881 hasConcept C2776745794 @default.
- W3206977881 hasConcept C33594762 @default.
- W3206977881 hasConcept C54355233 @default.
- W3206977881 hasConcept C64927066 @default.
- W3206977881 hasConcept C77445288 @default.
- W3206977881 hasConcept C83640560 @default.
- W3206977881 hasConcept C86339819 @default.
- W3206977881 hasConcept C86803240 @default.
- W3206977881 hasConcept C95444343 @default.
- W3206977881 hasConceptScore W3206977881C104317684 @default.
- W3206977881 hasConceptScore W3206977881C150194340 @default.
- W3206977881 hasConceptScore W3206977881C150425827 @default.
- W3206977881 hasConceptScore W3206977881C165864922 @default.
- W3206977881 hasConceptScore W3206977881C27153228 @default.
- W3206977881 hasConceptScore W3206977881C2776745794 @default.
- W3206977881 hasConceptScore W3206977881C33594762 @default.
- W3206977881 hasConceptScore W3206977881C54355233 @default.
- W3206977881 hasConceptScore W3206977881C64927066 @default.
- W3206977881 hasConceptScore W3206977881C77445288 @default.
- W3206977881 hasConceptScore W3206977881C83640560 @default.
- W3206977881 hasConceptScore W3206977881C86339819 @default.
- W3206977881 hasConceptScore W3206977881C86803240 @default.
- W3206977881 hasConceptScore W3206977881C95444343 @default.
- W3206977881 hasFunder F4320322120 @default.
- W3206977881 hasIssue "3" @default.
- W3206977881 hasLocation W32069778811 @default.
- W3206977881 hasLocation W32069778812 @default.
- W3206977881 hasLocation W32069778813 @default.
- W3206977881 hasLocation W32069778814 @default.
- W3206977881 hasOpenAccess W3206977881 @default.
- W3206977881 hasPrimaryLocation W32069778811 @default.
- W3206977881 hasRelatedWork W1553671245 @default.
- W3206977881 hasRelatedWork W2000722028 @default.
- W3206977881 hasRelatedWork W2089394515 @default.
- W3206977881 hasRelatedWork W2132621604 @default.
- W3206977881 hasRelatedWork W2526262876 @default.
- W3206977881 hasRelatedWork W2804524416 @default.
- W3206977881 hasRelatedWork W2949981671 @default.
- W3206977881 hasRelatedWork W3126585063 @default.
- W3206977881 hasRelatedWork W3164129868 @default.
- W3206977881 hasRelatedWork W3206977881 @default.
- W3206977881 hasVolume "43" @default.
- W3206977881 isParatext "false" @default.
- W3206977881 isRetracted "false" @default.
- W3206977881 magId "3206977881" @default.
- W3206977881 workType "article" @default.