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- W3206984067 abstract "Predicting disease progression remains a particularly challenging endeavor in chronic degenerative disorders and cancer, thus limiting early detection, risk stratification, and preventive interventions. Here, profiling the three chronic subtypes of myeloproliferative neoplasms (MPNs), we identify the blood platelet transcriptome as a proxy strategy for highly sensitive progression biomarkers that also enables prediction of advanced disease via machine-learning algorithms. The MPN platelet transcriptome reveals an incremental molecular reprogramming that is independent of patient driver mutation status or therapy. Subtype-specific markers offer mechanistic and therapeutic insights, and highlight impaired proteostasis and a persistent integrated stress response. Using a LASSO model with validation in two independent cohorts, we identify the advanced subtype MF at high accuracy and offer a robust progression signature toward clinical translation. Our platelet transcriptome snapshot of chronic MPNs demonstrates a proof-of-principle for disease risk stratification and progression beyond genetic data alone, with potential utility in other progressive disorders." @default.
- W3206984067 created "2021-10-25" @default.
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- W3206984067 date "2021-10-01" @default.
- W3206984067 modified "2023-09-28" @default.
- W3206984067 title "Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms" @default.
- W3206984067 cites W124485265 @default.
- W3206984067 cites W1853969127 @default.
- W3206984067 cites W1884746267 @default.
- W3206984067 cites W1968949305 @default.
- W3206984067 cites W1969653234 @default.
- W3206984067 cites W1977991745 @default.
- W3206984067 cites W1979438759 @default.
- W3206984067 cites W1982105192 @default.
- W3206984067 cites W1989846405 @default.
- W3206984067 cites W1990519285 @default.
- W3206984067 cites W1999574084 @default.
- W3206984067 cites W2008799537 @default.
- W3206984067 cites W2011702935 @default.
- W3206984067 cites W2015113479 @default.
- W3206984067 cites W2043781659 @default.
- W3206984067 cites W2045470441 @default.
- W3206984067 cites W2063756127 @default.
- W3206984067 cites W2068218670 @default.
- W3206984067 cites W2071832964 @default.
- W3206984067 cites W2080834951 @default.
- W3206984067 cites W2097360283 @default.
- W3206984067 cites W2097694060 @default.
- W3206984067 cites W2098863206 @default.
- W3206984067 cites W2110782562 @default.
- W3206984067 cites W2121404346 @default.
- W3206984067 cites W2124941733 @default.
- W3206984067 cites W2127199495 @default.
- W3206984067 cites W2130114404 @default.
- W3206984067 cites W2130410032 @default.
- W3206984067 cites W2138566208 @default.
- W3206984067 cites W2148574523 @default.
- W3206984067 cites W2151056789 @default.
- W3206984067 cites W2157394080 @default.
- W3206984067 cites W2157820287 @default.
- W3206984067 cites W2167551295 @default.
- W3206984067 cites W2170551349 @default.
- W3206984067 cites W2177784250 @default.
- W3206984067 cites W2179438025 @default.
- W3206984067 cites W2194304382 @default.
- W3206984067 cites W2195061194 @default.
- W3206984067 cites W2214074259 @default.
- W3206984067 cites W2223947877 @default.
- W3206984067 cites W2227341721 @default.
- W3206984067 cites W2263105379 @default.
- W3206984067 cites W2314279276 @default.
- W3206984067 cites W2416694183 @default.
- W3206984067 cites W2419140434 @default.
- W3206984067 cites W2469730812 @default.
- W3206984067 cites W2550879096 @default.
- W3206984067 cites W2557590973 @default.
- W3206984067 cites W2564597498 @default.
- W3206984067 cites W2567208701 @default.
- W3206984067 cites W2568164979 @default.
- W3206984067 cites W2581163069 @default.
- W3206984067 cites W2589944689 @default.
- W3206984067 cites W2591411211 @default.
- W3206984067 cites W2657254619 @default.
- W3206984067 cites W2668660359 @default.
- W3206984067 cites W2744377419 @default.
- W3206984067 cites W2745751687 @default.
- W3206984067 cites W2768112975 @default.
- W3206984067 cites W2773899764 @default.
- W3206984067 cites W2783739433 @default.
- W3206984067 cites W2805257547 @default.
- W3206984067 cites W2886108619 @default.
- W3206984067 cites W2903708756 @default.
- W3206984067 cites W2909222910 @default.
- W3206984067 cites W2941485643 @default.
- W3206984067 cites W2943979348 @default.
- W3206984067 cites W2944293062 @default.
- W3206984067 cites W2949269903 @default.
- W3206984067 cites W2949444664 @default.
- W3206984067 cites W2950975533 @default.
- W3206984067 cites W2952127554 @default.
- W3206984067 cites W2955417896 @default.
- W3206984067 cites W2965641704 @default.
- W3206984067 cites W2969805366 @default.
- W3206984067 cites W2996072467 @default.
- W3206984067 cites W3011398176 @default.
- W3206984067 cites W3012687330 @default.
- W3206984067 cites W3015161665 @default.
- W3206984067 cites W3017024756 @default.
- W3206984067 cites W3031385466 @default.